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Name : ureC (Haur_2452) Accession : YP_001545218.1 Strain : Herpetosiphon aurantiacus DSM 785 Genome accession: NC_009972 Putative virulence/resistance : Virulence Product : urease subunit alpha Function : - COG functional category : E : Amino acid transport and metabolism COG ID : COG0804 EC number : - Position : 3135302 - 3137011 bp Length : 1710 bp Strand : - Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp DNA sequence : ATGAGCTTATGGATTCCGCGCCAAACCTATGCCGATTTGTATGGCCCGACCAAAGGCGACCGCTTGCGTTTAGCCGATAC TGAATTAATTATCGAAATTGAACACGATTTTGCCCACTATGGCGATGAAATTACCTTCGGCGGCGGCAAGGTGATTCGCG ATGGCATGGGCCAAAGCAGCAGCGCCCACGATGTGCTCGATTTAGTCATTACCAACGCGATCATTATCGATCATTGGGGC ATCGTCAAAGGTGATATTGGGATCAAACAAGGCCGAATTGTTAAAGTTGGCAAGGCTGGCAATCCTGATACCATGGCCGG AGTTGACCCTGAATTGGTGGTTGGCGCGAATACCGAGGTGATCGCTGGCGAGCATATGATCGTCACCGCTGGCGGGATTG ATAGCCATATTCACTTTATTGCGCCTGGCCAAATTCCCGAAGCGCTTTCGAATGGCGTGACAACCCTACTTGGCGGCGGA ACTGGCCCAGCTACTGGCACCAAAGCCACCACCTGTACGCCAGGTGTTTGGAATATGGCGCGAATGCTGCAAGCCGCCGA TGCTTGGCCAGTTAATCTTGGCTTTTTGGGCAAAGGCAATGCTGCTCAGCCCGAATCGTTGATTCAGCAGATTCAGGCTG GCGCATGTGGCTTGAAATTGCACGAGGATTGGGGCACAACGCCCGCTGCGATCGACATGTGTTTGAGCGTGGCCGATCAA TACGATGTGCAAGTGGCAATTCACACCGACACAATCAACGAAGCTGGCTTTTTAGAAGATACAATTCGCGCGATTGCTGG CCGCACTATCCATACCTATCACACTGAGGGTGCGGGCGGCGGCCATGCTCCCGATATTATCAAAATTGCTGGCGAACGCT ATGTGCTACCCTCATCGACCAACCCCACCCGCCCATATACCGTCAACACGATCGCTGAACACCTTGATATGTTGATGGTT TGTCATCACCTTAATCCCCAAGTGCCTGAAGATGTGGCCTTTGCTGAAAGCCGGATTCGACCTGAAACCATCGCCGCCGA AGATATTTTGCATGATCTGGGAGTGATTAGCATGATCTCCAGCGATTCGCAGGCGATGGGTCGGGTTGGCGAAGTGGTGA CCCGCACATGGCAAACTGCCCACAAAATGAAGGTTCAGCGTGGTGCGTTGCTTGGCGATTCAGCTCGCAACGATAATCAA CGGGTCAAGCGTTATATTGCCAAATACACGATCAATCCAGCCTTAGCTCATGGCATTGCCCACGAAGTTGGCTCGATTGA GCCAGGTAAATTGGCTGATTTGGTGTTGTGGCAGCCGGCCTTTTTTGGCGTAAAACCTGAAATTATTGTCAAAGGTGGCT TGATTGCTTGGAATGCCATGGGCGATGCTAATGCTTCGATTCCCACGCCGCAGCCTGTGCTCTATCGCCCGATGTTTGGG GCTTTTGGCGGGGCGCTTGGTGCAACGAGTTTGACCTTTGTTTCAGCCGCCGCTCATGAATCAGGCATTGGTCAACAATT GAATTTACAAAAAGTGACTTCGGCGGTGCGCGGTTGCCGCAGCGTCCAAAAAGCCGATTTAATCCACAACAACGCTACTC CGCTGATCGAAGTTGATCCCGAAACTTATGCGGTACGTGCTGATGGTGAGCTATTGACCTGCGAGCCAGCTACGAGTTTG CCCTTGGCGCAGCGCTATTTCTTATTCTAA Protein sequence : MSLWIPRQTYADLYGPTKGDRLRLADTELIIEIEHDFAHYGDEITFGGGKVIRDGMGQSSSAHDVLDLVITNAIIIDHWG IVKGDIGIKQGRIVKVGKAGNPDTMAGVDPELVVGANTEVIAGEHMIVTAGGIDSHIHFIAPGQIPEALSNGVTTLLGGG TGPATGTKATTCTPGVWNMARMLQAADAWPVNLGFLGKGNAAQPESLIQQIQAGACGLKLHEDWGTTPAAIDMCLSVADQ YDVQVAIHTDTINEAGFLEDTIRAIAGRTIHTYHTEGAGGGHAPDIIKIAGERYVLPSSTNPTRPYTVNTIAEHLDMLMV CHHLNPQVPEDVAFAESRIRPETIAAEDILHDLGVISMISSDSQAMGRVGEVVTRTWQTAHKMKVQRGALLGDSARNDNQ RVKRYIAKYTINPALAHGIAHEVGSIEPGKLADLVLWQPAFFGVKPEIIVKGGLIAWNAMGDANASIPTPQPVLYRPMFG AFGGALGATSLTFVSAAAHESGIGQQLNLQKVTSAVRGCRSVQKADLIHNNATPLIEVDPETYAVRADGELLTCEPATSL PLAQRYFLF |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| ureC | NP_286680.1 | urease subunit alpha | Virulence | TAI | Protein | 7e-172 | 67 |
| ureC | NP_287088.1 | urease subunit alpha | Not tested | TAI | Protein | 7e-172 | 67 |
| ureC | YP_005684266.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 2e-165 | 63 |
| ureC | YP_005682174.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 1e-165 | 63 |
| ureC | YP_003784325.1 | urease subunit alpha | Not tested | PiCp 7 | Protein | 1e-165 | 63 |
| ureC | YP_005686358.1 | Urease alpha subunit | Not tested | PiCp 7 | Protein | 1e-165 | 63 |
| Gene | GenBank Accn | Product | ID of source DB | Alignment Type | E-val | Identity |
| ureC | YP_001545218.1 | urease subunit alpha | VFG0270 | Protein | 5e-158 | 63 |
