Gene Information

Name : Clos_2048 (Clos_2048)
Accession : YP_001513580.1
Strain : Alkaliphilus oremlandii OhILAs
Genome accession: NC_009922
Putative virulence/resistance : Resistance
Product : heavy metal translocating P-type ATPase
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG2217
EC number : -
Position : 2177801 - 2179648 bp
Length : 1848 bp
Strand : -
Note : TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; cadmium-translocating P-type ATPase; heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase domain protein hydrolase; E1-E2 ATPase-associated domain protein; KEGG: rci:RC

DNA sequence :
ATGTTTAAGCTGACAAAAGTTCAAACAGTATGGGTCTCTGGTATTCTTGCACTGGCATCCTTTATCTTGAAAAAAACCTT
AGGTTATGAAATACTTACCATTATACTGATGCTTCTGACGACAGTGATTGCGGGTACGCCGATCTTCAAAAAGGCAATCG
GCGCCCTACGATATGGTATTGTAGGGATTGATGCTTTAGTTACTGTAGCTGTTATTGGTGCTATTATTATAGGAGAATAT
TGGGAGGGTGCCGCTGTAACTTTTCTATTCATACTAGGGGATTATTTGGAATCAAGAACCATAGAGAAAACCAGATCCTC
CATTAAGGCACTTCTTGATTTGGCACCGGATACGGCTAGGGTAAAAAGAGATGGAATAGAAGTGGTGATTTCCCCAGATG
AGGTGGTACACGGAGATCTGGTAGTAGTAAAGCCCGGTGAGAAAATATCTGTAGACGGTACGCTGGTAGAAGGGGCTGCT
TATATCAATCAGGCCGCAATTACAGGAGAATCTTTTCCTGTTCGCCGCATTGTAGATGAAAAAGTGTTTTCTGGAACCAT
TATTGAATCCGGCTATGCCATTGTTCACGCAGACCGAGTCGGTGAAGATACGACCTTTGCAAGAATTTTACAGATGGTTG
AAGAGGCACAGGATAAGAAGGCAAAAACACAGAAATTTTTGGAGAAATTCTCCAGACACTATACGCCGACCATCATTGTA
TTAGCAGCTCTTCTATATTTTATAACAAAGGACATAGAGCTGGCATTGACGCTACTTGTAATTGCTTGCCCAGGTGCTCT
CGTCATCTCCACACCTGTTTCTATTGTCGCTGGAATTGGAAACGGTGCCAAACATGGTGTCTTAGTAAAAGGCGGAGAAG
TTATGGAGAAGCTAGGTACCGTAAAAGTAGTGGCTTTTGATAAAACTGGAACGTTAACGATTGGTAAACCCGGTGTTACG
AAAGTAAAATCCTACCAAATCAATGAAAATGAACTTTTAAGGATTGCAGCGATTGGAGAATCCTACTCGGAGCATCCCCT
AGGTAAAGCCATTGTTTTAGAAGCGACTAAAAGGGTTGGGAATATTACAGTTTCTCCTGAAGGTTTAGAAATTATCACAG
GTCAAGGAATCATTTTCATCTATGAAGGTGTAGAATATTATATTGGTAACAGAAAATTATTAGAAAGTAAAGGGATTCCT
TTGGGGAGCCACGAAGAATATTTAATCAGTGAAGAAGAGAAGGGCCAAACAGCAGTAATTGTAGGCAGCAAAGAAAGTAT
TTATGGTATTATTTCTATTGCAGACACCATCCGAGAAGATGCAAGAGCCTTGGTTGAAAATCTAAAGTCACAGGGCATCA
AAAAAGTTATAATGTTAACAGGTGACAATGCTAGGGCGGCAAAAGCAGTGGCAGATACCGTTGGTTTAGATGAATATTAC
AGTGAACTTTTGCCAGAAGATAAAGTAAAAACTTTAGAAAGACTTCAACACAAGTATGGAAGCGTTGCTATGGTAGGTGA
TGGCGTCAATGATGCTCCTGCGCTTGCATCTGCGGACTTAGGAATTGCCATTGGAGGGGCTGGAACCGATGTTGCTATGG
AAACAGCCGATGTAGTTCTAATGTCAGCGGAAATAGGAAGACTTTCCTATGCAATTGGTCTAAGTAGAGCTACGGTGCAT
AATATGAAACAAAACATTTACTTTGCACTGATGGTTGTAGCTGTACTTTTGGCTGGTGTGCTCTTTAAAACAGTGAATCT
ATCCTTTGGTATGCTCGTTCATGAAGGGTCTGTATTATTGGTAATTTTAAATGCAATCCGTTTGCTGAGATATAATAAAT
TAAAATGA

Protein sequence :
MFKLTKVQTVWVSGILALASFILKKTLGYEILTIILMLLTTVIAGTPIFKKAIGALRYGIVGIDALVTVAVIGAIIIGEY
WEGAAVTFLFILGDYLESRTIEKTRSSIKALLDLAPDTARVKRDGIEVVISPDEVVHGDLVVVKPGEKISVDGTLVEGAA
YINQAAITGESFPVRRIVDEKVFSGTIIESGYAIVHADRVGEDTTFARILQMVEEAQDKKAKTQKFLEKFSRHYTPTIIV
LAALLYFITKDIELALTLLVIACPGALVISTPVSIVAGIGNGAKHGVLVKGGEVMEKLGTVKVVAFDKTGTLTIGKPGVT
KVKSYQINENELLRIAAIGESYSEHPLGKAIVLEATKRVGNITVSPEGLEIITGQGIIFIYEGVEYYIGNRKLLESKGIP
LGSHEEYLISEEEKGQTAVIVGSKESIYGIISIADTIREDARALVENLKSQGIKKVIMLTGDNARAAKAVADTVGLDEYY
SELLPEDKVKTLERLQHKYGSVAMVGDGVNDAPALASADLGIAIGGAGTDVAMETADVVLMSAEIGRLSYAIGLSRATVH
NMKQNIYFALMVVAVLLAGVLFKTVNLSFGMLVHEGSVLLVILNAIRLLRYNKLK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SE0075 NP_763630.1 cadmium resistance protein B Not tested SCCpbp4 Protein 3e-96 44
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 1e-96 44
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 1e-96 44

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Clos_2048 YP_001513580.1 heavy metal translocating P-type ATPase BAC0092 Protein 1e-87 42