Gene Information

Name : Clos_1110 (Clos_1110)
Accession : YP_001512652.1
Strain : Alkaliphilus oremlandii OhILAs
Genome accession: NC_009922
Putative virulence/resistance : Resistance
Product : arsenite-activated ATPase ArsA
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG0003
EC number : 3.6.3.16
Position : 1206067 - 1207815 bp
Length : 1749 bp
Strand : +
Note : KEGG: cbo:CBO0755 arsenical pump-driving ATPase; TIGRFAM: arsenite-activated ATPase ArsA; PFAM: Anion-transporting ATPase; SMART: AAA ATPase

DNA sequence : 
ATGTTACTTAAAAACTTTGATCCAGCGGAGATCAACTTAACAAAATACTTATTTTTTACAGGAAAAGGAGGAGTTGGCAA
AACATCAACAGCTTGTGCTATTGCAGTAGCTTTAGCAGATAAAGGTAAAAAAATTATGCTTATAAGTACTGATCCAGCTT
CAAACCTGCAGGATGTATTTAATACAGAATTAAACAACAAAGGTGTACCTATAAAAGAAGTACCGAATTTAGTAGTAGCG
AACTTTGAACCAGAAAAGGCAGCAGCAGAATATAAGGAAAGTGTAATAGCTCCATACAGAGGAAAGCTTCCTGAAGCAGT
ACTTACAAATATGGAAGAACAACTTTCAGGATCTTGTACAGTTGAAATAGCAGCGTTTAATGAATTCTCAGGTTTCATAA
CTGATGAAAAGGCATCAAAGGAATACGATCACATTATATTCGATACTGCACCTACAGGTCATACATTAAGAATGCTTCAA
TTACCTTCAGCATGGACTAATTTTATTAGCGAAAACACCCATGGTGCATCCTGTTTAGGACAGTTATCAGGTCTTGAAGA
TAAAAAAGAAATTTACAAGCATGCAGTGGAAAACTTAGCTGATGGAGGAAAAACTACACTGATTTTAGTATCTCGTCCAG
AAGAATCAGCACTAAAAGAAGCTGAAAGAGCTTCTATAGAGCTTCAAGATATAGGAGTAAACAATCAACTTTTAGTAGTA
AATGGAGTACTTAAAGTACATGATGACGAACTTTCAACATCTATTTATATTAAACAAAAATCTGCATTAGACAATATGCC
AGAAGGGATTAAATCAATTCAAGCTTTTGAAATTCCATTAAGACCTTATAATGTAACTGGAATAGAAAATGTTAGATCCT
TTTTTAACAGTGATAATATTAAGCATAGTACTGAAGTCTTAAATGTGGATAAGATTCCTAATTTAAATGATGTAATTGAG
GATTTATATAAATCTGATAAAAAAGTGATTTTTACCATGGGTAAAGGTGGCGTAGGTAAAACTACAATAGCAGCTACTGT
TGCTCTAGAACTAGCAAAGAAAGGTAAGAAAGTACATCTAACAACAACGGACCCAGCGGCACACTTAAAATTTGTTTTAG
AGGAAGGTTATGGTATTACTATAAGCAATATTGATGAGAAAAAAGAGCTAGAAAAATATAAAGAAGAAGTATTAAGTAAA
GCAAGAGAGACAATGAGTGGTGATGATTTAGCCTATATAGAAGAGGACCTAAGATCACCATGTACTCAAGAAATAGCAGT
GTTTAGAGCATTTGCAGAAATAGTGGAAAGGTCAGAAAATGAAGTTGTAGTAATTGATACAGCACCTACAGGACATACAC
TATTATTGCTAGATTCAACTCAAAGTTATCACAAGGAAATTCAAAGATCCCAAGGAGATACACCAGAATCTGTTAAGAAC
TTACTGCCAAAACTAAGAGATGAGAAGCACACTGAAGTTTTAATTATAACGCTGCCTGAGGCCACTCCAGTTTACGAAGC
AATAAGACTGAAAGAAGATTTAGAGAGAGCCGATATTTTTGTTAAATGGTGGGTTATTAACTCAAGCTTTTATGCTACTA
ATACAACAAATGATATTTTAAAAGTAAAAGCAGGTAATGAGGTTGGGTGGATCAATAAAGTAAATGAAGTATCCAAAGGA
AACTTTGCAGTTATTAAGTGGACTCACGAAGAAGTAAAAGGTGAAAACCTAAGTAAACTTTTAAAATAG

Protein sequence : 
MLLKNFDPAEINLTKYLFFTGKGGVGKTSTACAIAVALADKGKKIMLISTDPASNLQDVFNTELNNKGVPIKEVPNLVVA
NFEPEKAAAEYKESVIAPYRGKLPEAVLTNMEEQLSGSCTVEIAAFNEFSGFITDEKASKEYDHIIFDTAPTGHTLRMLQ
LPSAWTNFISENTHGASCLGQLSGLEDKKEIYKHAVENLADGGKTTLILVSRPEESALKEAERASIELQDIGVNNQLLVV
NGVLKVHDDELSTSIYIKQKSALDNMPEGIKSIQAFEIPLRPYNVTGIENVRSFFNSDNIKHSTEVLNVDKIPNLNDVIE
DLYKSDKKVIFTMGKGGVGKTTIAATVALELAKKGKKVHLTTTDPAAHLKFVLEEGYGITISNIDEKKELEKYKEEVLSK
ARETMSGDDLAYIEEDLRSPCTQEIAVFRAFAEIVERSENEVVVIDTAPTGHTLLLLDSTQSYHKEIQRSQGDTPESVKN
LLPKLRDEKHTEVLIITLPEATPVYEAIRLKEDLERADIFVKWWVINSSFYATNTTNDILKVKAGNEVGWINKVNEVSKG
NFAVIKWTHEEVKGENLSKLLK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SH0111 YP_252026.1 arsenical pump-driving ATPase Not tested SCCmec Protein 3e-114 46
arsA2 YP_001007632.1 arsenical pump-driving ATPase Not tested YAPI Protein 5e-111 44

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Clos_1110 YP_001512652.1 arsenite-activated ATPase ArsA BAC0030 Protein 1e-107 45
Clos_1110 YP_001512652.1 arsenite-activated ATPase ArsA BAC0571 Protein 8e-110 44
Clos_1110 YP_001512652.1 arsenite-activated ATPase ArsA BAC0572 Protein 2e-109 44