Gene Information

Name : Clos_1074 (Clos_1074)
Accession : YP_001512617.1
Strain : Alkaliphilus oremlandii OhILAs
Genome accession: NC_009922
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 1171923 - 1173047 bp
Length : 1125 bp
Strand : -
Note : PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: gka:GK2540 cystathionine gamma-synthase

DNA sequence :
ATGGAATTTAATACATTAGTAATTCATGGGGGAATAGATGGTGATAAGAATACTGGTTCCGTTACAGTACCGATTTACCA
AACTTCTACCTATAGACAAGATGCTGTAGGTAAACATAAGGGTTACGAATATTCTAGAACAGGCAATCCCACTCGAGAAG
CCCTTGAAAAGCTGATATCTGATTTAGAAGGAGGTTATGCTGGATTTGCCTTTGGATCAGGAATGGCTGCTACCTCCTCC
GTACTTATGTTATTTAAAAATGGAGATCATATTATTCTTGGGGATGATGTATACGGAGGAACTTATCGTGTAATTGATAA
AGTCTTTTCTCAATTAGGAATTCAATATACTTCAGTAGATACGACAAACCCTATAAATATTGAAAAAGCTATTCAATCTA
ACACAAAAGCAATTTTTATGGAAACACCATCTAATCCTTTAATGAAGTTATCAGATATAGCTGCTATATCTGATATTGCT
AAGGCTCATAAGCTACTTCTTATAGTAGATAATACTTTTATGAGTCCCTACTTGCAAAGACCTATGGAACTAGGAGCTGA
TATCGTATTACACAGTGCTACAAAGTATCTAAGTGGGCATAGTGATGTGGTTGCTGGTTTAGCTGTAGTAAACTCAAAGG
AGTTAGCGAATAGTCTTCATTTTATACAAAATGCAGTAGGCGCCATATTAGGACCTCAGGATAGCTGGGTTTTAATGAAG
GGTATGAGAACTCTACCTTTGCGAATGGATCGTCACTGTGAAAATGCTTTAAAGATTTCCAAATGGCTTTCCAAGCAAAC
TTGGGTAAATAAAGTTTATTACCCTGGCCTATCTTCAGAAGTAGAAAATTACAAAAGTCAAATGAAAAATTTTGGGGGCA
TGCTTTCCTTTGAAGTTTCTGATGAAAACACCCTAGCGAAGTTAATGTCTAATCTAAAAATTATTACCTTAGCAGAAAGC
TTAGGTGGCATTGAAAGTTTAATCTCTGTACCTGCTAAGATGACACATGCTTCTATCCCTGTAGAAAAAAGAAATGCTAT
AGGGATTACAGATACTTTAGTTCGATTATCTGTTGGTGTTGAAGATGTGCAGGATATTATAAATGATTTAAATCCCTTTA
AATAG

Protein sequence :
MEFNTLVIHGGIDGDKNTGSVTVPIYQTSTYRQDAVGKHKGYEYSRTGNPTREALEKLISDLEGGYAGFAFGSGMAATSS
VLMLFKNGDHIILGDDVYGGTYRVIDKVFSQLGIQYTSVDTTNPINIEKAIQSNTKAIFMETPSNPLMKLSDIAAISDIA
KAHKLLLIVDNTFMSPYLQRPMELGADIVLHSATKYLSGHSDVVAGLAVVNSKELANSLHFIQNAVGAILGPQDSWVLMK
GMRTLPLRMDRHCENALKISKWLSKQTWVNKVYYPGLSSEVENYKSQMKNFGGMLSFEVSDENTLAKLMSNLKIITLAES
LGGIESLISVPAKMTHASIPVEKRNAIGITDTLVRLSVGVEDVQDIINDLNPFK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 6e-90 53
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 1e-88 52
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 2e-62 42

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Clos_1074 YP_001512617.1 cystathionine gamma-synthase BAC0207 Protein 4e-65 42