Gene Information

Name : Tlet_0827 (Tlet_0827)
Accession : YP_001470457.1
Strain : Thermotoga lettingae TMO
Genome accession: NC_009828
Putative virulence/resistance : Unknown
Product : carbamate kinase-like carbamoyl phosphate synthetase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0549
EC number : 2.7.2.2
Position : 841548 - 842483 bp
Length : 936 bp
Strand : -
Note : this enzyme from Pyrococcus has carbamoyl phosphate synthetase activity even though the enzyme shows sequence and structural similarity to carbamate kinase; this enzyme using carbate and ATP to synthesize carbamoyl phosphate which may be a favorable react

DNA sequence :
ATGAAAAAAACAGCTGTTCTTGCCATTGGTGGTAATGCAGTTAATAAACCTGGGGAGAGACCTACTGCTGAAAATATGCT
CAAAGCTCTCAATGAAGCTATGGGATATTTGAGTGATATGCTTGAAGAGTACGATATAGTTATCACTCATGGAAACGGCC
CACAGGTTGGGAATATACTGATTCAGCAGGAAATGGCAAAAGATGTGATACCTCCTTTTCCACTGGATGTAAATGACGCC
CAAACACAGGGTAGTCTTGGATACATGATAGTTCAATCTTTGAGAAATCAACTACAAAAAAAAGATATAAAAAAGCAAAT
CGCTGCGGTTGTTACACAGATAATCGTTGACAAAAACGATAAGGCTTTTCAAAATCCATCAAAACCGATCGGTCCATTTT
ATACAAAAGAAGAAGCTGAGAAATTGTCAAGATTAAAAGGGTGGATAATGAAAGAGGATGCAGGGAGAGGTTATAGAAGA
GTGGTTCCGTCACCAAAACCGCTTGATATTGTTGAAAAAGACGTGATTAAAATGTTGCTTGAAAATGACGTAATAGTCGT
AGCCGCTGGTGGCGGTGGCGTACCTGTGATAGAAAAAGATGGCTTTTTGCACGGTGTGGAGGCTGTTATAGATAAAGATA
GAGCAAGTTCACTTCTTGCAATAGAAATAAATGCTGATCTGTTCGTGATATTAACCGGCGTTGAAAAGGTGTCTTTGAAT
TATAAAAAACCAGATCAGATAGATCTTGATACACTTTCTGTGAAAGATGCAAAGACATATCTTGAACAAGGGCAGTTTCC
ATCTGGAAGCATGGGACCAAAGATAGAATCAGCAATAGAATTTGTCGAAGCAACAGGGAGAGAATGTATAATAAGCGATA
TCTCAAAACTGAAACAGGCGCTGAATGGTTTAACAGGGACACGCATAAAAGCATAG

Protein sequence :
MKKTAVLAIGGNAVNKPGERPTAENMLKALNEAMGYLSDMLEEYDIVITHGNGPQVGNILIQQEMAKDVIPPFPLDVNDA
QTQGSLGYMIVQSLRNQLQKKDIKKQIAAVVTQIIVDKNDKAFQNPSKPIGPFYTKEEAEKLSRLKGWIMKEDAGRGYRR
VVPSPKPLDIVEKDVIKMLLENDVIVVAAGGGGVPVIEKDGFLHGVEAVIDKDRASSLLAIEINADLFVILTGVEKVSLN
YKKPDQIDLDTLSVKDAKTYLEQGQFPSGSMGPKIESAIEFVEATGRECIISDISKLKQALNGLTGTRIKA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SE0102 NP_763657.1 carbamate kinase Not tested SCCpbp4 Protein 6e-50 46
APECO1_2636 YP_859422.2 carbamate kinase Not tested Not named Protein 4e-54 46
SAKOR_01091 YP_008491279.1 Carbamate kinase Not tested vSa¥ã Protein 3e-51 44
arcC1 YP_186045.1 carbamate kinase Not tested vSa¥ã Protein 7e-51 44
MW1051 NP_645868.1 carbamate kinase Not tested vSa¥ã Protein 7e-51 44
SAV1170 NP_371694.1 carbamate kinase Not tested vSa¥ã Protein 7e-51 44
SA1013 NP_374286.1 carbamate kinase Not tested vSa¥ã Protein 7e-51 44
arcC YP_493761.1 carbamate kinase Not tested vSa¥ã Protein 7e-51 44