Gene Information

Name : Tlet_1901 (Tlet_1901)
Accession : YP_001471519.1
Strain : Thermotoga lettingae TMO
Genome accession: NC_009828
Putative virulence/resistance : Virulence
Product : flagellar protein export ATPase FliI
Function : -
COG functional category : N : Cell motility
COG ID : COG1157
EC number : 3.6.3.15
Position : 1973732 - 1975042 bp
Length : 1311 bp
Strand : +
Note : KEGG: tma:TM0218 flagellum-specific ATP synthase; TIGRFAM: ATPase, FliI/YscN family; flagellar protein export ATPase FliI; PFAM: H+transporting two-sector ATPase alpha/beta subunit central region; H+transporting two-sector ATPase alpha/beta subunit domain

DNA sequence :
ATGAATGATATCCTGCAGATTCTGGAACTTTTGAAAAGCAGGATCGAGAGAGAAGATTTCCTCAAGATGAATGGGAGAGT
TAACCGAATAATTGGCCTCACTGTCGAATCAACCGGACCAGACGCTTTTCTGGGAGAACTTTGCAAATTGAATCTGGACG
GCAAAAAACCTCTCTGCGAGGTCGTTGGTTTCAGAGATGGGAAGGTTCTCTTGATGCCGCTCGAAGATCTATCGGGCGCC
AAGCATGGCACGTTTGTCTACAAAACTAACAGGCGCTTAGATGTAGGAGTATCAGAGGATATGAAAGGCAGAATTGTCGA
TGGATTGGGAAGGCCAATAGATGGAAAGCCGCTTATAGCTAAGCACAGATACCCTCTAATAAATAGTGCGCCTCATCCAT
TGAAAAGATCGAGGATCACTGCTCCTTTACCAGTTGGAGTTCGAGCTATAGATGGATTTATAACAATAGGAAAAGGTCAG
AGAATTGGCATTTTTGCCGGCAGCGGTGTTGGTAAAAGCACGTTACTTGGCATGATTGCCAGAAACACTGTAGCAGATGT
TAACGTAATAGCCCTTATTGGCGAAAGAGGCAGAGAGGTAAGAGAATTTATCGAAAAAGACCTCGCTAAGGGAATTGAAA
AATCAATAGTTGTCGTTTCAACATCCGATCAACCTGCTCTGATGCGTTCAAAAGCACTCTATACTGCTACAAGTATCGCC
GAATACTTCCGGGATCTTGGGTACGATGTTCTGCTAATGGTTGACTCTCTAACCCGCTGGGCAATGGCCCAGCGAGAGAT
AGGTCTTGCAATAGGGGAACCTCCAACAGCCAGAGGTTATCCACCAAGTGTGTTTGCTGGAATTCCTGGCATTCTGGAAA
GAGCGGGAAATTCGGACAAAGGTAGCATCACTGCTATATACACAGTGCTTGTCGAGGCGGATGACTTTAATGAACCAATC
TCGGACACTGTCAGAAGCGTTGTAGATGGTCATATTATGCTCTCAAGAAGACTATCTGAATTGAATCACTATCCAGCCAT
AGATGTACTTGCAAGTGTAAGCAGATTGATGGTGGATATCGTTGGTCATGATCACCTTGAGGCAAGCAGAAATCTTCGCA
ATTTAATGGCAACTTATTATGAAGCAAAAGATCTCATCGATGTAGGGGCTTATAAACCAGGATCGAATCCACAGATAGAC
AGAGCAATAAAAATGATAGATCCCATAAACAGCTTTCTCAAACAAAGAATAGATGAAAAACCTGATTATAAAGACACCGT
GGCCGAACTTTTAAAGCTTGCTAACAGATAG

Protein sequence :
MNDILQILELLKSRIEREDFLKMNGRVNRIIGLTVESTGPDAFLGELCKLNLDGKKPLCEVVGFRDGKVLLMPLEDLSGA
KHGTFVYKTNRRLDVGVSEDMKGRIVDGLGRPIDGKPLIAKHRYPLINSAPHPLKRSRITAPLPVGVRAIDGFITIGKGQ
RIGIFAGSGVGKSTLLGMIARNTVADVNVIALIGERGREVREFIEKDLAKGIEKSIVVVSTSDQPALMRSKALYTATSIA
EYFRDLGYDVLLMVDSLTRWAMAQREIGLAIGEPPTARGYPPSVFAGIPGILERAGNSDKGSITAIYTVLVEADDFNEPI
SDTVRSVVDGHIMLSRRLSELNHYPAIDVLASVSRLMVDIVGHDHLEASRNLRNLMATYYEAKDLIDVGAYKPGSNPQID
RAIKMIDPINSFLKQRIDEKPDYKDTVAELLKLANR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
hrcN YP_362163.1 type III secretion system ATPase Virulence Hrp PAI Protein 3e-92 52
hrpB6 AAB08461.1 HrpB6 Virulence Hrp PAI Protein 2e-92 52
lscN AAO18044.1 LscN Virulence TTSS locus Protein 1e-92 52
YPO0267 YP_002345348.1 type III secretion system ATPase Virulence Not named Protein 2e-87 52
hrpB6 BAB07852.1 HrpB6 Virulence Hrp PAI Protein 5e-95 51
hrpB6 AAF61281.1 HrpB6 Virulence Hrp PAI Protein 5e-95 51
hrcN YP_198730.1 type III secretion system ATPase Virulence Hrp PAI Protein 7e-95 51
hrcN NP_640767.1 type III secretion system ATPase Virulence Hrp PAI Protein 5e-94 50
hrcN AAP34339.1 HrcN Virulence Hrp PAI Protein 7e-94 50
XC_3006 YP_244074.1 type III secretion system ATPase Virulence Hrp PAI Protein 8e-93 50
hrcN NP_636610.1 type III secretion system ATPase Virulence Hrp PAI Protein 8e-93 50
ssaN NP_456113.1 putative type III secretion ATP synthase Virulence SPI-2 Protein 1e-80 49
ssaN CAA70537.1 secretion system apparatus Virulence SPI-2 Protein 4e-81 49
ssaN NP_805086.1 type III secretion system ATPase Virulence SPI-2 Protein 1e-80 49
ssaN NP_460380.1 type III secretion system ATPase Virulence SPI-2 Protein 5e-81 49
ssaN YP_216423.1 type III secretion system ATPase Virulence SPI-2 Protein 2e-81 49
escN AFO66300.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 9e-84 48
escN AFO66415.1 putative LEE-encoded type III secretion system ATPase Virulence SESS LEE Protein 9e-84 48
escN YP_003236088.1 translocator EscN Virulence LEE Protein 5e-83 48
escN NP_290268.1 hypothetical protein Virulence LEE Protein 4e-82 48
escN AAC31513.1 L0034 Virulence LEE Protein 3e-82 48
ECs4568 NP_312595.1 EscN Virulence LEE Protein 4e-82 48
unnamed ACU09458.1 type III secretion apparatus H+-transporting two-sector ATPase Virulence LEE Protein 3e-82 48
escN YP_003232153.1 T3SS structure protein EscN Virulence LEE Protein 8e-83 48
escN CAI43874.1 EscN protein Virulence LEE Protein 7e-83 47
unnamed AAL06369.1 EscN Virulence LEE Protein 7e-82 47
escN YP_003223475.1 translocator EscN Virulence LEE Protein 1e-82 47
escN AAL57542.1 EscN Virulence LEE Protein 2e-82 47
escN CAC81862.1 EscN protein Virulence LEE II Protein 8e-83 47
escN AAC38383.1 EscN Virulence LEE Protein 3e-82 47
escN AAK26715.1 EscN Virulence LEE Protein 2e-82 47
hrcN AAB06001.1 HrcN Virulence Hrp PAI Protein 9e-82 46
hrcN AAG33879.1 HrcN Virulence Hrp PAI Protein 1e-73 45
hrcN AAR25633.1 type III secretion cytoplasmic ATPase HrcN Not tested Not named Protein 3e-72 45
hrcN NP_791227.1 type III secretion cytoplasmic ATPase HrcN Virulence Hrp PAI Protein 2e-75 45
hrcN AAT96141.1 HrcN Virulence T-PAI Protein 3e-76 45
hrcN AAT96195.1 HrcN Virulence T-PAI Protein 2e-76 45
hrcN ABA47275.1 HrcN Virulence S-PAI Protein 1e-78 43
hrpJ4 AAA81942.1 HrpJ4 Virulence Hrp PAI Protein 5e-68 43
hrcN ABQ88354.1 HrcN Virulence Hrp PAI Protein 5e-68 43
hrcN AAT96299.1 HrcN Virulence S-PAI Protein 2e-73 43
hrcN AAT96258.1 HrcN Virulence S-PAI Protein 1e-73 43
hrcN AAT96339.1 HrcN Virulence S-PAI Protein 6e-74 43
invC YP_217813.1 ATP synthase SpaL Virulence SPI-1 Protein 3e-64 41
spaI NP_457288.1 secretory apparatus ATP synthase (associated with virulence) Virulence SPI-1 Protein 3e-64 41
spaI NP_806497.1 ATP synthase SpaL Virulence SPI-1 Protein 3e-64 41
invC NP_461815.1 ATP synthase SpaL Virulence SPI-1 Protein 3e-64 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Tlet_1901 YP_001471519.1 flagellar protein export ATPase FliI VFG0192 Protein 5e-97 52
Tlet_1901 YP_001471519.1 flagellar protein export ATPase FliI VFG2144 Protein 2e-95 50
Tlet_1901 YP_001471519.1 flagellar protein export ATPase FliI VFG0048 Protein 6e-94 50
Tlet_1901 YP_001471519.1 flagellar protein export ATPase FliI VFG0390 Protein 1e-92 50
Tlet_1901 YP_001471519.1 flagellar protein export ATPase FliI VFG1254 Protein 1e-87 50
Tlet_1901 YP_001471519.1 flagellar protein export ATPase FliI VFG0515 Protein 2e-81 49
Tlet_1901 YP_001471519.1 flagellar protein export ATPase FliI VFG0812 Protein 2e-82 48
Tlet_1901 YP_001471519.1 flagellar protein export ATPase FliI VFG2499 Protein 4e-88 48
Tlet_1901 YP_001471519.1 flagellar protein export ATPase FliI VFG0730 Protein 2e-82 47
Tlet_1901 YP_001471519.1 flagellar protein export ATPase FliI VFG2331 Protein 8e-86 46
Tlet_1901 YP_001471519.1 flagellar protein export ATPase FliI VFG0555 Protein 1e-64 41
Tlet_1901 YP_001471519.1 flagellar protein export ATPase FliI VFG2459 Protein 2e-67 41
Tlet_1901 YP_001471519.1 flagellar protein export ATPase FliI VFG1008 Protein 6e-64 41