Gene Information

Name : spaP (EcHS_A3018)
Accession : YP_001459638.1
Strain : Escherichia coli HS
Genome accession: NC_009800
Putative virulence/resistance : Virulence
Product : surface presentation of antigens protein SpaP
Function : -
COG functional category : U : Intracellular trafficking, secretion and vesicular transport
COG ID : COG4790
EC number : -
Position : 3021684 - 3022349 bp
Length : 666 bp
Strand : -
Note : part of a type III secretory system probably involved in invasion into eukaryotic cells

DNA sequence :
ATGTCAAATAGCATTTCGCTGATAGCTATACTATCATTATTTACACTATTGCCGTTTATAATAGCATCCGGGACATATTT
TATTAAATTCTCGATTGTTTTTGTTATTGTCCGAAACGCGCTGGGGCTTCAGCAAGTGCCATCAAATATGACACTTAATG
GGGTTGCTTTGCTATTGTCAATGTTTGTAATGATGCCGGTTGGGAAGGAAATATATTATAACAGTCAGAATGAGAATCTT
TCATTCAATAATTTAGCGTCGGTTGTTAATTTTGTTGAGACAGGCATGAGTGGTTATAAATCATATTTGATAAAATATTC
CGAACCGGAGTTGGTTAACTTTTTTGAAAAGATTCAGAAGGTGAATAGCTCTGAAGACAATGAAGAGATATTCGATGATG
ATAATATTTCAATTTTCTCGTTACTCCCGGCATATGCGTTGAGTGAGATAAAAAGTGCATTTATTATAGGTTTTTATATC
TATTTACCCTTTGTTGTAGTGGATCTGGTTATATCCATCGTTCTGTTAACGTTAGGTATGATGATGATGAGTCCGGTAAC
CATATCTACACCGATAAAATTAATTTTGTTTGTCGCGATGGACGGTTGGACAATGTTATCAAAAGGACTCATTTTACAAT
ATTTTGACCTATCCATTAATCCCTGA

Protein sequence :
MSNSISLIAILSLFTLLPFIIASGTYFIKFSIVFVIVRNALGLQQVPSNMTLNGVALLLSMFVMMPVGKEIYYNSQNENL
SFNNLASVVNFVETGMSGYKSYLIKYSEPELVNFFEKIQKVNSSEDNEEIFDDDNISIFSLLPAYALSEIKSAFIIGFYI
YLPFVVVDLVISIVLLTLGMMMMSPVTISTPIKLILFVAMDGWTMLSKGLILQYFDLSINP

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
epaP AAZ31293.1 EpaP Virulence ETT2 Protein 2e-71 98
spaP NP_311752.1 surface presentation of antigens protein SpaP Not tested LIM Protein 1e-71 98
spaP YP_217809.1 surface presentation of antigens protein SpaP Virulence SPI-1 Protein 5e-51 67
spaP NP_461811.1 surface presentation of antigens protein SpaP Virulence SPI-1 Protein 5e-51 67
spaP NP_457284.1 secretory protein (associated with virulence) Virulence SPI-1 Protein 1e-50 66
spaP NP_806493.1 surface presentation of antigens protein SpaP Virulence SPI-1 Protein 1e-50 66
spaP AAS66865.1 SpaP Not tested SSR-2 Protein 5e-51 58
ysaR AAS66846.1 YsaR Not tested SSR-1 Protein 5e-46 56
lscR AAO18040.1 LscR Virulence TTSS locus Protein 2e-29 44
escR YP_003223490.1 T3SS structure protein EscR Virulence LEE Protein 3e-26 43
escR CAC81847.1 EscR protein Virulence LEE II Protein 2e-26 43
escR YP_003232138.1 type III secretion system protein Virulence LEE Protein 3e-26 43
escR CAI43889.1 EscR protein Virulence LEE Protein 2e-26 43
escR AAK26700.1 EscR Virulence LEE Protein 2e-26 43
escR AAL57527.1 EscR Virulence LEE Protein 2e-26 43
ECs4583 NP_312610.1 type III secretion system protein Virulence LEE Protein 2e-26 42
escR AAC38369.1 EscR Virulence LEE Protein 1e-25 42
escR AAC31528.1 L0049 Virulence LEE Protein 2e-26 42
escR ACU09473.1 type III secretion system protein EscR Virulence LEE Protein 2e-26 42
escR YP_003236103.1 T3SS structure protein EscR Virulence LEE Protein 3e-26 42
escR NP_290283.1 type III secretion system protein Virulence LEE Protein 3e-26 42
unnamed AAL06354.1 EscR Virulence LEE Protein 8e-25 41
escR AFO66317.1 putative LEE-encoded type III secretion system factor Virulence SESS LEE Protein 4e-23 41
escR AFO66400.1 putative LEE-encoded type III secretion system factor Virulence SESS LEE Protein 4e-23 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
spaP YP_001459638.1 surface presentation of antigens protein SpaP VFG0551 Protein 2e-51 67
spaP YP_001459638.1 surface presentation of antigens protein SpaP VFG1773 Protein 2e-51 61
spaP YP_001459638.1 surface presentation of antigens protein SpaP VFG2455 Protein 1e-48 60
spaP YP_001459638.1 surface presentation of antigens protein SpaP VFG1012 Protein 4e-45 58
spaP YP_001459638.1 surface presentation of antigens protein SpaP VFG0188 Protein 7e-30 45
spaP YP_001459638.1 surface presentation of antigens protein SpaP VFG0394 Protein 7e-29 45
spaP YP_001459638.1 surface presentation of antigens protein SpaP VFG0827 Protein 1e-26 42
spaP YP_001459638.1 surface presentation of antigens protein SpaP VFG0715 Protein 6e-26 42
spaP YP_001459638.1 surface presentation of antigens protein SpaP VFG0044 Protein 4e-27 41