Gene Information

Name : cvrA (EcHS_A1294)
Accession : YP_001458012.1
Strain : Escherichia coli HS
Genome accession: NC_009800
Putative virulence/resistance : Unknown
Product : potassium/proton antiporter
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG3263
EC number : -
Position : 1288774 - 1290510 bp
Length : 1737 bp
Strand : -
Note : the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli

DNA sequence :
TTGGATGCCACAACAATAATTAGCCTTTTCATCTTAGGATCCATCCTTGTCACCAGCAGTATATTACTTAGTTCATTTTC
TTCCCGTCTTGGCATTCCTATTCTGGTTATTTTTCTGGCGATCGGCATGCTGGCAGGAGTCGATGGCGTCGGCGGTATCC
CGTTTGATAATTACCCCTTCGCCTACATGGTAAGTAACCTGGCACTGGCGATTATTTTGCTCGACGGCGGGATGCGCACT
CAGGCCAGTTCCTTTCGTGTGGCGTTAGGACCGGCACTGTCGCTGGCGACGCTGGGCGTGCTTATCACCTCTGGTTTAAC
CGGCATGATGGCGGCGTGGCTGTTTAATCTTGATTTGATTGAAGGCTTATTAATCGGCGCTATCGTCGGCTCTACCGATG
CTGCAGCGGTCTTTTCTCTGCTGGGTGGTAAGGGGCTTAACGAACGTGTTGGCTCGACGCTGGAAATTGAATCCGGCAGT
AATGATCCAATGGCGGTCTTTCTGACGATTACCCTGATTGCGATGATCCAGCATCATGAGAGCAATATTAGCTGGATGTT
CATTGTCGATATTCTGCAACAATTTGGTCTGGGCATTGTAATAGGTCTTGGCGGCGGTTATTTACTACTGCAAATGATCA
ACCGCATCGCCCTGCCCGCCGGATTATATCCATTGCTGGCATTAAGTGGCGGTATTCTGATTTTCTCATTAACTACTGCG
CTGGAAGGTAGCGGTATTCTGGCGGTGTATCTGTGCGGTTTTCTGCTGGGTAATCGCCCTATTCGCAACCGCTACGGCAT
CCTGCAAAATTTCGACGGCCTCGCCTGGCTGGCGCAAATCGCCATGTTCCTGGTGCTGGGGCTGTTGGTTAACCCAAGCG
ATCTGCTGCCTATTGCCATTCCGGCGCTCATTTTGTCCGCATGGATGATATTCTTCGCCCGTCCCCTTTCGGTATTTGCT
GGATTGCTCCCCTTCCGCGGTTTCAATCTGCGTGAGCGCGTGTTTATCAGCTGGGTAGGATTACGCGGCGCGGTGCCAAT
CATCCTGGCCGTGTTCCCGATGATGGCGGGGCTGGAGAATGCACGTCTGTTCTTTAATGTCGCCTTCTTTGTGGTTCTGG
TTTCACTGCTCTTGCAGGGAACATCACTCTCGTGGGCGGCTAAAAAAGCCAAAGTGGTGGTTCCGCCAGTGGGACGTCCG
GTGTCACGCGTTGGCCTGGATATTCATCCGGAAAATCCGTGGGAGCAGTTTGTTTATCAATTGAGTGCCGATAAATGGTG
CGTGGGCGCGGCACTGCGCGATTTGCATATGCCAAAAGAGACGCGTATTGCGGCACTGTTTCGTGATAACCAGTTGCTTC
ATCCTACCGGCAGCACCCGACTGCGCGAAGGCGATGTGTTGTGTGTAATTGGTCGGGAACGCGATCTTCCGGCGCTCGGT
AAACTGTTCAGCCAGTCGCCGCCGGTCGCGCTGGATCAACGCTTCTTTGGTGACTTCATTCTCGAAGCCAGCGCCAAATA
TGCTGATGTTGCGCTGATATATGGCCTGGAAGACGGGCGAGAATATCGTGATAAGCAGCAAACGCTGGGTGAAATTGTCC
AGCAGTTGTTAGGCGCGGCACCGGTTGTCGGTGACCAGGTAGAGTTTGCCGGGATGATCTGGACGGTGGCCGAGAAAGAA
GATAATGAAGTGTTGAAGATTGGCGTACGGGTGGCTGAAGAGGAAGCTGAATCTTAA

Protein sequence :
MDATTIISLFILGSILVTSSILLSSFSSRLGIPILVIFLAIGMLAGVDGVGGIPFDNYPFAYMVSNLALAIILLDGGMRT
QASSFRVALGPALSLATLGVLITSGLTGMMAAWLFNLDLIEGLLIGAIVGSTDAAAVFSLLGGKGLNERVGSTLEIESGS
NDPMAVFLTITLIAMIQHHESNISWMFIVDILQQFGLGIVIGLGGGYLLLQMINRIALPAGLYPLLALSGGILIFSLTTA
LEGSGILAVYLCGFLLGNRPIRNRYGILQNFDGLAWLAQIAMFLVLGLLVNPSDLLPIAIPALILSAWMIFFARPLSVFA
GLLPFRGFNLRERVFISWVGLRGAVPIILAVFPMMAGLENARLFFNVAFFVVLVSLLLQGTSLSWAAKKAKVVVPPVGRP
VSRVGLDIHPENPWEQFVYQLSADKWCVGAALRDLHMPKETRIAALFRDNQLLHPTGSTRLREGDVLCVIGRERDLPALG
KLFSQSPPVALDQRFFGDFILEASAKYADVALIYGLEDGREYRDKQQTLGEIVQQLLGAAPVVGDQVEFAGMIWTVAEKE
DNEVLKIGVRVAEEEAES

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed AAB61290.1 unknown Not tested PAI I CFT073 Protein 0.0 99
f536 AAC61706.1 F536 Not tested PAI I CFT073 Protein 0.0 99