Gene Information

Name : guaA (CKO_00280)
Accession : YP_001451879.1
Strain : Citrobacter koseri ATCC BAA-895
Genome accession: NC_009792
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : -
Position : 273580 - 275157 bp
Length : 1578 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACGGAAAATATTCATAAACATCGCATTCTCATCCTGGATTTTGGTTCTCAGTACACTCAGCTGGTTGCGCGTCGCGT
GCGTGAACTCGGCGTTTACTGCGAACTGTGGGCGTGGGATGTTACGGAAGCACAAATTCGCGAATTCAACCCAAGCGGTA
TTATTCTTTCCGGCGGCCCGGAAAGCACCACTGAAGAAAACAGCCCACGCGCGCCGGAGTATGTGTTTGAAGCTGGCGTG
CCGGTATTCGGCGTGTGCTACGGCATGCAGACGATGGCGATGCAACTGGGCGGCCATGTTGAAGCATCCAATGAACGTGA
ATTCGGTTACGCGCAGGTGGAAGTGAGAACCAACAGCGCGCTGATTCGCGGCATTGAAGACTCCCTGACCGCAGACGGCA
AGCCGCTGCTGGACGTGTGGATGAGCCACGGCGATAAAGTTACCGCTATCCCGTCTGATTTTGTCACCGTTGCCAGCACC
GAAACCTGCCCGTTCGCCATTATGGCTAACGAGGAAAAACGTTTTTACGGCGTGCAGTTCCACCCGGAAGTCACACACAC
CCGTCAGGGTATGCGCATGCTGGAACGCTTTGTGCGTGATATCTGCCAGTGTGAAGCGCTGTGGACTCCGGCGAAGATTA
TCGACGATGCGGTAAATCGCATTCGTGAACAGGTTGGCGACGACAAAGTGATCCTCGGCCTGTCTGGCGGCGTTGACTCT
TCCGTTACCGCGATGCTGCTGCACCGTGCCATCGGTAAAAACCTGACCTGCGTATTCGTTGATAACGGCCTGCTGCGTCT
GAACGAAGCCGAGCAGGTAATGGACATGTTCGGCGATCATTTTGGTCTCAACATTGTTCACGTTCCGGCGGAAGAACGTT
TCCTGACCGCGCTGAAAGGCGAAAACGATCCAGAAGCGAAACGTAAGATCATCGGTCGCGTATTCGTTGAAGTCTTTGAC
GAAGAAGCGTTCAGACTCGAAGACGTGAAATGGCTGGCGCAGGGCACTATCTATCCTGACGTTATCGAGTCCGCCGCTTC
CGCCACCGGTAAAGCGCACGTCATCAAATCTCACCACAATGTGGGCGGCTTGCCGAAAGAGATGAAGATGGGTCTGGTTG
AGCCGCTGAAAGAGCTGTTCAAAGACGAAGTGCGCAAGATTGGTCTGGAACTGGGCCTGCCGTACGACATGCTGTACCGT
CATCCGTTCCCGGGGCCGGGTCTTGGCGTTCGCGTACTGGGCGAAGTGAAGAAAGAGTACTGCGACCTGCTGCGTCGTGC
GGATGCTATCTTCATCGAAGAGTTGCACAAAGCGGATCTGTACAACAAAGTGAGCCAGGCGTTCACCGTGTTCCTGCCGG
TTCGTTCCGTTGGCGTAATGGGCGATGGCCGTAAATACGACTGGGTTGTCTCCCTGCGTGCGGTAGAAACCATCGACTTT
ATGACCGCGCACTGGGCGCACCTGCCGTATGATTTCCTCGGCCGCGTCTCTAACCGCATCATCAACGAAGTCAACGGCAT
CTCCCGCGTGGTGTATGACATCAGCGGTAAGCCGCCAGCAACCATTGAGTGGGAATGA

Protein sequence :
MTENIHKHRILILDFGSQYTQLVARRVRELGVYCELWAWDVTEAQIREFNPSGIILSGGPESTTEENSPRAPEYVFEAGV
PVFGVCYGMQTMAMQLGGHVEASNEREFGYAQVEVRTNSALIRGIEDSLTADGKPLLDVWMSHGDKVTAIPSDFVTVAST
ETCPFAIMANEEKRFYGVQFHPEVTHTRQGMRMLERFVRDICQCEALWTPAKIIDDAVNRIREQVGDDKVILGLSGGVDS
SVTAMLLHRAIGKNLTCVFVDNGLLRLNEAEQVMDMFGDHFGLNIVHVPAEERFLTALKGENDPEAKRKIIGRVFVEVFD
EEAFRLEDVKWLAQGTIYPDVIESAASATGKAHVIKSHHNVGGLPKEMKMGLVEPLKELFKDEVRKIGLELGLPYDMLYR
HPFPGPGLGVRVLGEVKKEYCDLLRRADAIFIEELHKADLYNKVSQAFTVFLPVRSVGVMGDGRKYDWVVSLRAVETIDF
MTAHWAHLPYDFLGRVSNRIINEVNGISRVVYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 3e-128 51
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-128 51
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-128 51
guaA NP_938969.1 GMP synthase Not tested Not named Protein 5e-110 48