Gene Information

Name : tpx (CKO_01399)
Accession : YP_001452970.1
Strain : Citrobacter koseri ATCC BAA-895
Genome accession: NC_009792
Putative virulence/resistance : Virulence
Product : thiol peroxidase
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG2077
EC number : -
Position : 1356566 - 1357072 bp
Length : 507 bp
Strand : -
Note : antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein

DNA sequence :
ATGTCACAAACCGTTCATTTCCAGGGCAATCCAGTCGCCGTCGCCAACACCATTCCTCAAGCTGGTAGCAAAGCACAGGC
TTTTACCCTCGTGGCAAAAGATCTGTCTGACGTCACACTGGCTCAGTTTGCAGGCAAGCGCAAGGTGCTGAATATTTTCC
CAAGTATTGATACCGGCGTTTGTGCGGCATCGGTACGTAAGTTTAACCAACTGGCGACAGAAATCGACAACACCGTCGTA
CTGTGCGTTTCTGCGGATCTGCCGTTCGCCCAGTCTCGTTTCTGCGGCGCGGAAGGTCTGAGCAACGTCATTACCCTTTC
CACTCTGCGTAATCCTGACTTCCTGAAAGACTACGGCGTTGAAATCACTGAAGGCCCGCTGAAAGGTCTGGCGGCGCGTG
CCGTGGTGGTCATTGATGAAAACGACAACGTCATTTTCAGCCAGTTGGTGAACGAAATCACCAACGAACCTGACTATGCT
GCTGCGCTGGACGTGCTGAAAGCGTAA

Protein sequence :
MSQTVHFQGNPVAVANTIPQAGSKAQAFTLVAKDLSDVTLAQFAGKRKVLNIFPSIDTGVCAASVRKFNQLATEIDNTVV
LCVSADLPFAQSRFCGAEGLSNVITLSTLRNPDFLKDYGVEITEGPLKGLAARAVVVIDENDNVIFSQLVNEITNEPDYA
AALDVLKA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tpx YP_001216305.1 thiol peroxidase Not tested VPI-1 Protein 3e-35 50
tpx NP_230472.1 thiol peroxidase Virulence VPI-1 Protein 1e-35 50
tagD AAK20751.1 toxR-activated gene D protein Virulence VPI Protein 2e-35 50
tagD AAK20781.1 toxR-activated gene D protein Virulence VPI Protein 8e-36 50

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
tpx YP_001452970.1 thiol peroxidase VFG0087 Protein 3e-36 50