Gene Information

Name : lysS (SGO_0753)
Accession : YP_001450052.1
Strain : Streptococcus gordonii Challis
Genome accession: NC_009785
Putative virulence/resistance : Virulence
Product : lysyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG1190
EC number : 6.1.1.6
Position : 791823 - 793313 bp
Length : 1491 bp
Strand : -
Note : class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA

DNA sequence :
ATGACTACTGAACATTTTGAAGAATTAAATGACCAGCAAATTATTCGCCGTGAAAAAATGGCTGCGCTGGCTGAGCAAGG
AATTGATCCTTTCGGAAAACGTTTTGAGCGCACTGCAAACTCTGGACAATTAAAAGAAAAATACGCAGATAAAAGTAAAG
AAGAGTTGCACGACTTAGCTGATACAGCTACTATTGCTGGACGTCTCATGACTAAACGTGGTAAAGGAAAAGTTGGATTT
GCTCACATCCAAGACCGCGAGGGCCAAATTCAAATTTACGTCCGCAAAGATGAAGTCGGTGAAGAAAACTATGAAATCTT
TAAAAAAGCTGACTTAGGCGACTTCCTTGGAGTTGAAGGTGAAGTGATGCGTACTGATATGGGAGAATTATCTATCAAAG
CTACCCATATTACCCACCTTTCTAAAGCACTTCGTCCCCTTCCTGAAAAATTCCATGGACTGACAGATGTGGAGACTATT
TATCGCAAACGCTATTTGGATTTGATTTCTAACCGTGAGAGCTTCAATCGATTTGTTACTCGCTCAAAAATCATTTCTGA
AATTCGCCGTTACTTAGACGGGCAAGGCTTCCTTGAAGTCGAAACTCCTGTTCTCCACAATGAAGCAGGTGGTGCTGCTG
CCCGTCCTTTCATTACTCATCACAATGCCCAAAATATCGATATGGTGCTTCGAATTGCAACTGAATTGCACCTTAAGCGC
CTCATTGTAGGTGGTATGGAACGGGTCTATGAAATCGGACGTATCTTCCGTAACGAAGGAATGGACGCTACTCATAATCC
AGAGTTTACGTCTATTGAAGTTTACCAAGCTTATGCAGACTTCCAAGATATTATGGACTTGACAGAAGGAATTATTCAAC
ATGCAGCTATCTCTGTATGTGGAGATGGACCTATAAACTATCAGGGAACTGAAATCAAGATCAATGAACCATTTAAACGC
GTTCATATGGTAGATGCCATCAAGGAAATTACTGGCGTAGATTTCTGGCAAGATATGAGCTTTGAAGAAGCCACTGCCTT
GGCCAAAGAAAAGAATGTTCCTCTCGAAAAGCACTTCACAGAAGTCGGCCATGTTATTAATGCTTTCTTTGAAGAATTTG
TTGAAGAAACCTTAACTCAACCAACCTTTATCTATGGTCATCCTGTTGCAGTATCTCCTCTGGCTAAGAAAAATCCAGAA
GATCCACGTTTCACTGACCGTTTCGAGCTCTTCATCATGACCAAGGAATATGCCAACGCCTTCACCGAATTGAACGATCC
AATCGATCAACTCTCTCGTTTTGAAGCCCAAGCTAAAGCTAAAGAACTAGGTGATGACGAAGCTACCGGCATTGACTACG
ACTATGTAGAAGCTCTAGAATATGGTATGCCACCAACTGGAGGTCTAGGTATTGGGATTGACCGTCTAGTTATGTTGCTG
ACTGACGTGACTACCATTCGTGATGTCCTTCTCTTCCCGACAATGAAATAA

Protein sequence :
MTTEHFEELNDQQIIRREKMAALAEQGIDPFGKRFERTANSGQLKEKYADKSKEELHDLADTATIAGRLMTKRGKGKVGF
AHIQDREGQIQIYVRKDEVGEENYEIFKKADLGDFLGVEGEVMRTDMGELSIKATHITHLSKALRPLPEKFHGLTDVETI
YRKRYLDLISNRESFNRFVTRSKIISEIRRYLDGQGFLEVETPVLHNEAGGAAARPFITHHNAQNIDMVLRIATELHLKR
LIVGGMERVYEIGRIFRNEGMDATHNPEFTSIEVYQAYADFQDIMDLTEGIIQHAAISVCGDGPINYQGTEIKINEPFKR
VHMVDAIKEITGVDFWQDMSFEEATALAKEKNVPLEKHFTEVGHVINAFFEEFVEETLTQPTFIYGHPVAVSPLAKKNPE
DPRFTDRFELFIMTKEYANAFTELNDPIDQLSRFEAQAKAKELGDDEATGIDYDYVEALEYGMPPTGGLGIGIDRLVMLL
TDVTTIRDVLLFPTMK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed CAD66193.1 putative lysil-tRNA synthetase LysU Not tested PAI III 536 Protein 9e-108 47

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
lysS YP_001450052.1 lysyl-tRNA synthetase VFG1668 Protein 5e-108 47