Gene Information

Name : tpx (SGO_1803)
Accession : YP_001451072.1
Strain : Streptococcus gordonii Challis
Genome accession: NC_009785
Putative virulence/resistance : Virulence
Product : thiol peroxidase
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG2077
EC number : -
Position : 1877267 - 1877758 bp
Length : 492 bp
Strand : +
Note : antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein

DNA sequence : 
ATGACAACTTTTCTCGGAAATCCTGTAACCTTTACTGGAAAACAACTACAAGTCGGTGACACAGCCCATGATTTTAGCCT
GACAGCAACGGATCTTTCAAAGAAAACTCTGGCTGATTTTGCTGGCAAAAAGAAAGTTCTAAGCATCATCCCATCTATCG
ATACTGGTGTCTGCTCGACTCAGACTCGCCGCTTCAACCAAGAACTCTCTGACTTGGACAACACAGTTGTTATCACAGTT
TCAGTTGATTTGCCTTTTGCACAAGGCAAGTGGTGCGCTGCTGAAGGCATTGAGAATGCTGTGATGTTATCTGACTACTT
TGACCATTCTTTCGGCCGTGACTATGCTGTCCTCATCAATGAATGGCACCTTTTGGCCCGCGCAGTTCTCGTTCTAGATG
AGAACAACACTGTGACCTACGCTGAATATGTCGACAATATCAACACTGAACCTGACTATGATGCAGCGATTGCAGCAGTG
AAAAACTTATAA

Protein sequence : 
MTTFLGNPVTFTGKQLQVGDTAHDFSLTATDLSKKTLADFAGKKKVLSIIPSIDTGVCSTQTRRFNQELSDLDNTVVITV
SVDLPFAQGKWCAAEGIENAVMLSDYFDHSFGRDYAVLINEWHLLARAVLVLDENNTVTYAEYVDNINTEPDYDAAIAAV
KNL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tpx YP_001216305.1 thiol peroxidase Not tested VPI-1 Protein 6e-22 42
tpx NP_230472.1 thiol peroxidase Virulence VPI-1 Protein 3e-22 42
tagD AAK20751.1 toxR-activated gene D protein Virulence VPI Protein 4e-22 42
tagD AAK20781.1 toxR-activated gene D protein Virulence VPI Protein 2e-22 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
tpx YP_001451072.1 thiol peroxidase VFG0087 Protein 8e-23 42