Gene Information

Name : guaA (Rcas_1739)
Accession : YP_001431849.1
Strain : Roseiflexus castenholzii DSM 13941
Genome accession: NC_009767
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : -
Position : 2236456 - 2237994 bp
Length : 1539 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGCACGAATCAATCCCAGTTCTCGATTTTGGCTCGCAGACAGCGCAACTGATCGTCCGCCGCCTGCGTGAACTTGGCGT
GTACAGCGAACTGTTGCCGCACGACACCCCAGAAGCCGACGTGTGGGCGTTGCAACCACGCGGCATTGTTCTTTCCGGCG
GACCGGCAAGCGTCTATGAGCCAGGCGCGCCGCAGTTGCCGCCATGGCTGCTCGAAAGCGACCTGCCGGTGCTTGGTATT
TGCTACGGGATGCAGTTGCAGGCACACACCCTCGGTGGGCGCGTCGAAGGTATGCAGAGCCGTGAGTTTGGTCCGGCAGA
GATCACCGTCGTCGATCCCGATCTGCTGTTCGCCGATATGCCGACACAACAACAGGTGTGGATGAGCCACGGCGATCACA
TTGCTGCGCTGCCCCCTGGATTTCGCGTGCTGGCACACAGCCCCGGCGCGCCATTTGCTGCCGCAGGCGACGACCGACGT
CGCTGGTATGGCATTCAGTTCCATCCCGAAGTCGTGCATACGCGCTTCGGGCGCGACATATTGCGCAACTTCGCCTTCCG
TATTTGCAAATGCCGCGGCGACTGGCAACCGGAAAACTTTGTCGCTGAGGCAATCGAGCGCGTGCGCGCGCAGGTCGGCG
ATGGGCGGGTGATCTGTGCGCTTTCCGGCGGCGTCGACTCGGCGGTTGCCGCGCTGATCGTCCATCACGCCATCGGCGAC
CGGTTGACGTGCGTTTTTGTGGACAATGGTTTGCTGCGCCAGGGTGAAGCCGAACAGGTTGTCGCCACCTTCCGTGAGCA
TTTTCATATTCCCCTGATCGCCGTCGATGCAGCAGATGAATTTCTCGAAGCGCTTGCTGGCGTTGCCGACCCGGAACAGA
AGCGCACAATCATCGGCGAAAAGTTCGTGCGCATCTTCGAACGTGAAGCGCGCCGCATCGAAGGCGCGCGCTTCCTCGCG
CAGGGCACGCTTTACCCCGACGTGATCGAAAGCAGAGCGCCGGATCGCCAGAAAGGCGTAACCATCAAAACCCACCACAA
TGTCGGCGGATTGCCCGCCGATATGCAGTTGACCCTCGTCGAACCATTGCGCTACCTGTTCAAGGACGAAGTGCGCGCCG
CCGGTCATGCCCTGGGGCTGCCGGACGAATGGGTCTGGCGGCATCCCTTCCCTGGACCAGGGCTTGCCGTGCGGGTGCTT
GGTCCGGTGACGCGCGAGCGCCTCGCAACGCTGCGCGCTGCCGACGCCATTTTCATGCAGGAATTGCGCATTGCCGGATT
ATACCGCGCAACGCAACAGGCGTTTGCAGTGCTGTTGCCGGTACGCAGCGTCGGCGTGATGGGCGATGGACGCACCTACG
CTGATGTGGTGGCGCTCCGCGCCGTGACGACCGAGGATTATATGACGGCGGATTGGGCGCGCCTCCCCGCTGAACTGCTG
GCGCGCGTGAGCAGCCGCATTGTGAACGAGGTTCCCGGCGTCAATCGTGTGGTGTACGACATCTCCTCCAAACCCCCGGC
AACGATTGAGTGGGAATAG

Protein sequence :
MHESIPVLDFGSQTAQLIVRRLRELGVYSELLPHDTPEADVWALQPRGIVLSGGPASVYEPGAPQLPPWLLESDLPVLGI
CYGMQLQAHTLGGRVEGMQSREFGPAEITVVDPDLLFADMPTQQQVWMSHGDHIAALPPGFRVLAHSPGAPFAAAGDDRR
RWYGIQFHPEVVHTRFGRDILRNFAFRICKCRGDWQPENFVAEAIERVRAQVGDGRVICALSGGVDSAVAALIVHHAIGD
RLTCVFVDNGLLRQGEAEQVVATFREHFHIPLIAVDAADEFLEALAGVADPEQKRTIIGEKFVRIFEREARRIEGARFLA
QGTLYPDVIESRAPDRQKGVTIKTHHNVGGLPADMQLTLVEPLRYLFKDEVRAAGHALGLPDEWVWRHPFPGPGLAVRVL
GPVTRERLATLRAADAIFMQELRIAGLYRATQQAFAVLLPVRSVGVMGDGRTYADVVALRAVTTEDYMTADWARLPAELL
ARVSSRIVNEVPGVNRVVYDISSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 4e-142 56
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 6e-142 56
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 5e-142 56
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-125 54