Gene Information

Name : kdsB (FTA_1486)
Accession : YP_001428917.1
Strain : Francisella tularensis FTNF002-00
Genome accession: NC_009749
Putative virulence/resistance : Virulence
Product : 3-deoxy-manno-octulosonate cytidylyltransferase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG1212
EC number : 2.7.7.38
Position : 1328855 - 1329607 bp
Length : 753 bp
Strand : -
Note : CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS

DNA sequence : 
ATGGCTAATATTCATATTGTAATTCCTGCCAGGCTTAAATCAACTCGTCTACCAAATAAAATGCTGGCAGATATTGCCGG
TAAGCCAATGATTCAGAGAGTCTATGAGCAAGTGACTAAATCAAAGTTTGATAGCATAATAATAGCTACAGATTCGCAAA
AAATAAAAGATATCGCAGAGAGCTTTGGTGCAAAAGTAGTTTTGACAAGAGATGATCATCAATCAGGAACAGATAGAATA
GCAGAAGCAGTTACTAAATTAGGCTTTGCAGATGAAGACATTGTTGTAAATGTCCAAGGTGATGAGCCATTGATCCCTAT
TGAAAATATCGAGCAAGCTGCGCAGTTATTGATAGACAAATCAGAAGCTGTAGTCTCGACGTTGTGTGAAAAAATCACAG
ATGTAGAAGATATTTATAATCCTAATAATGTCAAAGTAGTTTTTGATAAAAATAACTATGCTTTATATTTTAGTAGAGCA
TCTATTCCTTTTGAAAGAGGTTTTTCTGAGAAAGAGCAGATTAATATTTCAGAATTTTTTAGACATATTGGTATATATGC
ATATCGAGTAGCTTTTTTAAAACATTATGCAGAACTTACAGTTTCACCAATTGAGAAATACGAAGCTCTTGAACAGCTAA
GAGTCTTATATAATGGTTACAAAATCGCTATTGAGCAATCAGCTAAATCAACTCCTGCTGGTGTTGATACATTGCAAGAT
TTAGAAAAAGTAAGGAAATTATTTAATGTTTAA

Protein sequence : 
MANIHIVIPARLKSTRLPNKMLADIAGKPMIQRVYEQVTKSKFDSIIIATDSQKIKDIAESFGAKVVLTRDDHQSGTDRI
AEAVTKLGFADEDIVVNVQGDEPLIPIENIEQAAQLLIDKSEAVVSTLCEKITDVEDIYNPNNVKVVFDKNNYALYFSRA
SIPFERGFSEKEQINISEFFRHIGIYAYRVAFLKHYAELTVSPIEKYEALEQLRVLYNGYKIAIEQSAKSTPAGVDTLQD
LEKVRKLFNV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
kpsU YP_854332.1 3-deoxy-manno-octulosonate cytidylyltransferase Not tested PAI I APEC-O1 Protein 3e-42 43
kpsU CAE85213.1 KpsU protein Virulence PAI V 536 Protein 4e-42 43
kpsU AAZ04469.1 CMP-KDO synthetase Virulence PAI I APEC-O1 Protein 2e-42 43