Gene Information

Name : thyA (CBUD_0442)
Accession : YP_001423860.2
Strain : Coxiella burnetii Dugway 5J108-111
Genome accession: NC_009727
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 425216 - 426106 bp
Length : 891 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGGCTAATTTTATTAACGACTATGGTGGCGCAAACGCATATGTCGCCGGCGGCCGTGAAAGCCTCTGCACGCGTGCCCG
TTATAGCGGTGGTTCGATGAAAGAATATCTTAATTTTTTGCAATTTATCCTTGATCACGGAGTCGCTAAAACGGACCGGA
CCGGAATAGGAACGAAAAGTGTTTTCGGCTACGAAATGCGCTTTAATCTGCGGGAAGGTTTTCCGTTAGTTACCACTAAG
AAAATCCATTTGAAAAGTGTTATTTATGAATTGTTATGGTTTTTACGGGGTGACACGAATATTCAGTTTTTAAACGACAA
TGGTGTAACCATTTGGGATGAATGGGCCGATGAAAACGGCGATTTAGGTCCGATTTATGGCAAACAATGGCGTCGCTGGC
ACTGCCCGGATGGTCGCACCGTCGATCAAATGCAACGATTAATTCGCGAAATAAAAACTAACCCCGATTCACGGCGTTTA
ATTGTCAGCGCCTGGAATGTCGGTGAACTTGATCAAATGGCATTGCCACCCTGTCATTTACTTTTTCAATTTTATGTGGC
GGATGGTTTTCTTTCTTGTAAATTAACGCAACGTTCAGCCGACGCTTTTTTAGGCGTGCCGTTTAATATTGCTTCTTATT
CACTTTTAACTCACCTGATCGCGCGACAATGCAATTTAAAAGCGGGTGAATTTATTTGGTCTGGCGGAGATTGTCATATT
TATAATACCCATCAAGACCAAGTAAGCACCCAATTGTCGCGCGAGCCACGTGCTTTACCTCAATTAATCATCAACCGTGA
TCCTTCATCCTTATACGATTATAATTTTAACGATTTTTCCATCGTGAATTATCACCCACATCCCGCTATTAAAGCGCCGG
TCGCGGTGTAG

Protein sequence :
MANFINDYGGANAYVAGGRESLCTRARYSGGSMKEYLNFLQFILDHGVAKTDRTGIGTKSVFGYEMRFNLREGFPLVTTK
KIHLKSVIYELLWFLRGDTNIQFLNDNGVTIWDEWADENGDLGPIYGKQWRRWHCPDGRTVDQMQRLIREIKTNPDSRRL
IVSAWNVGELDQMALPPCHLLFQFYVADGFLSCKLTQRSADAFLGVPFNIASYSLLTHLIARQCNLKAGEFIWSGGDCHI
YNTHQDQVSTQLSREPRALPQLIINRDPSSLYDYNFNDFSIVNYHPHPAIKAPVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 1e-82 64