Gene Information

Name : guaA (Fnod_0220)
Accession : YP_001409744.1
Strain : Fervidobacterium nodosum Rt17-B1
Genome accession: NC_009718
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : -
Position : 223642 - 225210 bp
Length : 1569 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGTTAGAGGAAAAGAGAAACCAAAAAAAAGAAACAGTCGTTGTGCTTGATTTTGGATCCCAGTACACTCAACTTATCCT
TCGAAGAGTAAGGGAGTTGGGTTTTTATTGCGAACTGTTGCCTTACGATGAGCCTTGGGAAAATGTTGAAAAACTGTCAC
CTGTCGCATTTATTCTATCCGGTGGACCTTCCAGCGTTTACGATGAAAATGCACCAAAAATACCTCAGTATGTTTTCGAT
TCCAATCTTCCAGTGCTCGGTATCTGTTACGGATTACAGGCAATCGTTCACCAACTTGGTGGGAAAGTAGAAAAATCAAC
TCATAGAGAGTTTGGGCCAGCAACGTTAAATGTAATTAAACATGTTGGAATCTTCCAAAATTTACCGAATTCTTTCACAG
TTTGGATGAGTCACTCAGATAGAGTGGAAGTTTTACCTGAAAACTTCGAAGTTATAGCTAGAAGTGAAAATTCACCTTAT
GCAGCTGTTAGAAGTATTGACGATAGATTTTATGGGGTACAATTTCATCCTGAAGTTGCCCACACTCAATTTGGTAAACA
GATTCTTGAAAATTTTCTAAAGAAAGTAGCCAAACTCAATCCAAATTGGAAGATATCAAACCTTGCTGAGCAGATAATAG
AAGATTTGAGAAGAAAAATAGACGGAAGAGTTATACTTGGGCTATCCGGTGGTGTGGATTCTTCGGTTGTAGCCATGTTG
CTTCACAAAGCGGTACCAGACAAATTCATACCGATATTCGTTGACACGGGATTGCTAAGAAAAAATGAATGTATCGAAGT
AGTTAAACAATTCGAAGAAATAGGCATACATATACACTATGTTGATGCCTCCGAGAAATTCTTGGAGGTGTTAGATGGTG
TGGAAGACCCGGAAGAAAAAAGAAAGAGAATTGGTCACACGTTCATAGATGTTTTTTATGAAGAAGCAATGAAATTAAAA
GAAAAGTATGGTGATATCAAATACTTAGCTCAAGGAACACTCTATCCGGATATTATCGAAAGTAAAGTTGCCGAAAGAAA
AGCCGGTGCGAAGATAAAGACGCATCACAACGTTGGTGGGTTACCAGAGAAATTACCATTCGAAATTATCGAACCACTGA
GATATCTCTTCAAAGATGAAGTAAGAATGTTAGGTCAAGAAATTGGCTTACCGTCAAGTATTTTGAAACGTCATCCATTT
CCAGGTCCAGGATTAGCTGTGAGAATCATCGGATCTGTAACAAGAGAAGCTGTAAAAACATTGCAAGAGGCTGATTTCAT
ATTCATAGAAGAACTTAAAAAATGGGACCTTTACGACAAAGTCTGGCAAGCATTTGCCGTATTATTACCGATTAAAAGCG
TTGGAGTTATGGGAGATTACAGAACATATGAAAATGTTATCGCACTCAGAGCGGTAACAAGTGAAGATGGTATGACAGCA
GATTGGGCAAAATTGCCACACGATTTTCTAAACCATGTGGCGAAAAGAATTGTCAACGAAGTAAAAGGAGTAAACAGAGT
GGTTTACGATATCACATCGAAACCACCTGCAACAATCGAATGGGAATAA

Protein sequence :
MLEEKRNQKKETVVVLDFGSQYTQLILRRVRELGFYCELLPYDEPWENVEKLSPVAFILSGGPSSVYDENAPKIPQYVFD
SNLPVLGICYGLQAIVHQLGGKVEKSTHREFGPATLNVIKHVGIFQNLPNSFTVWMSHSDRVEVLPENFEVIARSENSPY
AAVRSIDDRFYGVQFHPEVAHTQFGKQILENFLKKVAKLNPNWKISNLAEQIIEDLRRKIDGRVILGLSGGVDSSVVAML
LHKAVPDKFIPIFVDTGLLRKNECIEVVKQFEEIGIHIHYVDASEKFLEVLDGVEDPEEKRKRIGHTFIDVFYEEAMKLK
EKYGDIKYLAQGTLYPDIIESKVAERKAGAKIKTHHNVGGLPEKLPFEIIEPLRYLFKDEVRMLGQEIGLPSSILKRHPF
PGPGLAVRIIGSVTREAVKTLQEADFIFIEELKKWDLYDKVWQAFAVLLPIKSVGVMGDYRTYENVIALRAVTSEDGMTA
DWAKLPHDFLNHVAKRIVNEVKGVNRVVYDITSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-124 51
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-124 51
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-124 51
guaA NP_938969.1 GMP synthase Not tested Not named Protein 4e-122 48