Gene Information

Name : guaA (CHAB381_0638)
Accession : YP_001406222.1
Strain : Campylobacter hominis ATCC BAA-381
Genome accession: NC_009714
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 582663 - 584198 bp
Length : 1536 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGAAAAATTCTGACATTATTGTTTTAGATTTTGGTTCTCAATACACTCAGTTGATCGCGCGCAGACTTCGCGAACAAGG
CGTTTATACCGAAATTTTGCCGTTTAATGCTAAAATTTCACAAATCAAAGAAAAAAATCCGAAAGGTCTGATTTTAAGCG
GCGGACCTGCCAGTGTTTATGCAAAAGACGCTTACTTTCCGAATGATGAAATTTTTAATTTGAATTTGCCGATTCTTGGT
ATTTGTTATGGAATGCAACTTATCGCTTATCATTTTGGCGCAAGTGTAACACCTACAAATAAAAAAGAGTATGGAAAATC
AAATTTAAAATTCGTAAGCGAAAATGCACTGCTCAAAGATACAAAAGACGGACAAATCGTTTGGATGAGCCATAGCGACA
AGGTTGAAAATTTGCCTGATGGTTTTAAAACGATAGCGGTTAGTGAAAATTCGCCGTTTTGCGCATTTTGCGATGAAAAA
AGAAAAATTTACGCTTTACAGTTTCATCCTGAAGTCGCTCACAGCGAATGTGGCGATAAAATTCTAAAAAATTTCGCCAA
ATATATTTGCGACTGCGAAAGCACTTGGAATATGGGCAATTTTGCCAAAATCAAATGCGAAGAGATAAAAAAACAAGTCG
GAAAAGATAGAGTGCTTTGCGCTGTAAGCGGTGGCGTGGACAGTTCTGTCGTTGCAGCACTTTTGGCGCATTGCATAAAA
GAAAATTTAATCGTGGTTTTTGTTGATAACGGACTTTTAAGAACTGACGAAGCAAAACAGGTCGAGCAGACTTTTAAACT
TAAACTTGGCGTTGAACTTATCAGCATAGACGCAAGCGAGCTGTTTTTAGGACGTTTAAAAGGCATAACAGACCCTGAAG
AAAAGCGCAAAATCATAGGAAAAACTTTTATTGAAGTTTTCGAGCGCGAAGCAAAAAAACATCAAAATGTAAAATATCTG
GCACAAGGCACACTTTATACGGATATCATAGAAAGCAGCGTTGTAGGCAGCTCAAAAACGATAAAATCTCATCACAATGT
CGGCGGACTTCCAAAAGATATGAAATTTAAACTAATCGAACCGCTAAAAGAAATTTTTAAAGATGAAGTCAGAAAACTTG
GAACAGAGCTTGGACTTAGTCCTGATTTGGTCTATCGTCATCCGTTTCCAGGCCCAGGTCTTGCAATTAGAATTTTAGGT
GAAATCACACCTGAAAAACTTTGCGTTTTACGAAAAGCGGATGTGATTTTGCGCGATGAACTGAAATCAAGCGGTTGGTA
TAACAAAACATGGCAGGCATTTTGTGTGCTTTTAAATGTAAACTCAGTTGGAGTTATGGGCGATAATAGAACTTATGAAA
ATGCGGTTTGCATTCGCGTAGTCGATGCAAGCGATGGAATGACGGCAAGTTTTTCAAGACTGCCATATGATCTGCTTGAA
AATATAAGCCGTCGTATCATAAATGAAGTCGATGGAATCAACCGCGTAGTTTATGATATCTCAAGCAAGCCACCTGCAAC
GATCGAGTGGGAGTAG

Protein sequence :
MKNSDIIVLDFGSQYTQLIARRLREQGVYTEILPFNAKISQIKEKNPKGLILSGGPASVYAKDAYFPNDEIFNLNLPILG
ICYGMQLIAYHFGASVTPTNKKEYGKSNLKFVSENALLKDTKDGQIVWMSHSDKVENLPDGFKTIAVSENSPFCAFCDEK
RKIYALQFHPEVAHSECGDKILKNFAKYICDCESTWNMGNFAKIKCEEIKKQVGKDRVLCAVSGGVDSSVVAALLAHCIK
ENLIVVFVDNGLLRTDEAKQVEQTFKLKLGVELISIDASELFLGRLKGITDPEEKRKIIGKTFIEVFEREAKKHQNVKYL
AQGTLYTDIIESSVVGSSKTIKSHHNVGGLPKDMKFKLIEPLKEIFKDEVRKLGTELGLSPDLVYRHPFPGPGLAIRILG
EITPEKLCVLRKADVILRDELKSSGWYNKTWQAFCVLLNVNSVGVMGDNRTYENAVCIRVVDASDGMTASFSRLPYDLLE
NISRRIINEVDGINRVVYDISSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-136 55
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 1e-136 55
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 1e-136 54
guaA NP_938969.1 GMP synthase Not tested Not named Protein 9e-119 49