Gene Information

Name : iucA (YpsIP31758_0714)
Accession : YP_001399703.1
Strain : Yersinia pseudotuberculosis IP 31758
Genome accession: NC_009708
Putative virulence/resistance : Virulence
Product : aerobactin siderophore biosynthesis protein IucA
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG4264
EC number : -
Position : 874770 - 876542 bp
Length : 1773 bp
Strand : -
Note : Part of the aerobactin biosynthesis operon.; identified by match to protein family HMM PF04183

DNA sequence : 
ATGACTATCCCAGTAGAAACCTTAGCAACCGATGTGGCTGCTCAATGTTTCCTCAACGCGCTGATTCGTGAAACCCAGGA
CTGGCAGATCGTTCCGGCAGCGGGCCACCAACCGTACCCACAACTCCACATTCCTCTTTCTTCTTCACACGCTATCCACA
TTGCCTTATGCCATATCTCCCCAACACAGCATCATCACTATCTGTTCCCTGCCTACCTGCATCAGCAGGGTAATGATAGG
CAGGATGATGACACCCCGGTAAAACTCGGGATCGAACAGTTGGTGACGCTTCTGTTGGAGAAGCCAACGGTAAAAGGTGA
GCTGTCTGATGATGTGGTTGCTCGTTTCCGTCAACGGGTGCTAGAAAGTCATGATAATACTCAGCAAGCGATTAATATTC
GTCTGGATTGGCCGTCATTACGCGATAAACCACTTAATTTTGCCCAGGCAGAACAAGGATTACTGGCCGGCCATGCCTTT
CACCCGGCACCGAAATCCCATCAACCTTTTAATGAAAAACAGGCCCAGCGTTATCTGCCCGATTTTGCCTCCCGCTTCCC
ACTACGCTGGTTTGCAGTCGATAAACGCTACCTGTGCGGCGATAGCCTAAAGCTAACGCTACAACACCGGCTGCAACGCT
TTGCCAGCGAAAGCGCCCCACAATTACTCGCGTATTTTACCGATGACGTTTGGCTGCTCCCCATGCACCCCTGGCAAGCC
GATCACCTATTGAAACAAGACTGGTGCCAGCAATTAGTACAACAAAACGCGTTGCATGATCTGGGCGAAGCGGGTGAACG
CTGGCTACCCACCAGCTCTTCACGTTCACTGTACAGCCCGTCAAACCGCGACATGGTCAAGTTCTCACTCAGTGTGCGCC
TGACCAACTCAGTACGAACCCTGTCGGTAAAAGAGGCCAAACGCGGTATGCGCTTGGCACGTTTGGCTCAAACACCCCGC
TGGCAAGAGCTGCAAGCGCGCTACCCGACTTTCCGTGTGATGCAGGAAGATGGTTGGGCCGGTTTGCGTTCAGCCGATTT
CACTCTTCAAGAAGAGAGTCTGTTGGTGCTACGTGACAACCTGCTATTCAGCCAACCCGATAGCCAGACCAATGTGTTGG
TCACCTTGACACAAGCCGCGCCCGATGGGGGGGACAGCCTGCTGGCCAGTGCTGTGCGTCGTTTGGCTGCCCGTCTGAAT
CTGCCATTGCAACAGGCCGCTTTCTGCTGGCTGGATGCTTACTGCCAGCACGTCTTATTGCCACTGTTCAGCACCGAGGC
TGACTACGGGCTGGTGTTGTTAGCGCATCAGCAAAATATTCTGGTGGAGATGCAGCAAGATCTGCCTGTCGGTATGTTGT
ACCGCGACTGCCAAGGGAGCGGCTTTACCCAGAGCGCGCTGCCGTGGTTGGCGGAAATTGGCGAAGCCGAAGCGGAAAAT
AGCTTTAGCGAACAGCAATTATTACGTTACTTCCCGTATTACCTGCTGGTGAACTCCAGCCTCGCGGTAACGGCTGCCTT
GGCTGCCGCAGGTTTCGACAGCGAGGAAAATTTGATGGTTCGTGTGCGTGACGCACTCAGCGCCCTGCGTACTTGCGCCA
AAAACACCTTATGTCTGGATTACGTACTTGATAGCCCACATTGGCACTGCAAAGGTAATTTCTTCTGCTATCTACACGAT
CACAACGAAAACACCATCGTTGATCCGGCAGTGATCTACTTCGATTTCGTTAACCCTCTGCACCAGGGGGTGATCCATGG
GGCCACACGCTAA

Protein sequence : 
MTIPVETLATDVAAQCFLNALIRETQDWQIVPAAGHQPYPQLHIPLSSSHAIHIALCHISPTQHHHYLFPAYLHQQGNDR
QDDDTPVKLGIEQLVTLLLEKPTVKGELSDDVVARFRQRVLESHDNTQQAINIRLDWPSLRDKPLNFAQAEQGLLAGHAF
HPAPKSHQPFNEKQAQRYLPDFASRFPLRWFAVDKRYLCGDSLKLTLQHRLQRFASESAPQLLAYFTDDVWLLPMHPWQA
DHLLKQDWCQQLVQQNALHDLGEAGERWLPTSSSRSLYSPSNRDMVKFSLSVRLTNSVRTLSVKEAKRGMRLARLAQTPR
WQELQARYPTFRVMQEDGWAGLRSADFTLQEESLLVLRDNLLFSQPDSQTNVLVTLTQAAPDGGDSLLASAVRRLAARLN
LPLQQAAFCWLDAYCQHVLLPLFSTEADYGLVLLAHQQNILVEMQQDLPVGMLYRDCQGSGFTQSALPWLAEIGEAEAEN
SFSEQQLLRYFPYYLLVNSSLAVTAALAAAGFDSEENLMVRVRDALSALRTCAKNTLCLDYVLDSPHWHCKGNFFCYLHD
HNENTIVDPAVIYFDFVNPLHQGVIHGATR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
iucA NP_839223.1 siderophore biosynthesis protein Virulence SHI-2 Protein 2e-156 63
iucA NP_709454.2 siderophore biosynthesis protein Virulence SHI-2 Protein 2e-156 63
iucA AAD44746.1 IucA Virulence SHI-2 Protein 1e-156 63
iucA YP_002414046.1 aerobactin siderophore biosynthesis protein Virulence Not named Protein 1e-156 63
iucA AAK71631.1 IucA Virulence SHI-3 Protein 4e-139 59

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
iucA YP_001399703.1 aerobactin siderophore biosynthesis protein IucA VFG0615 Protein 8e-157 63
iucA YP_001399703.1 aerobactin siderophore biosynthesis protein IucA VFG0940 Protein 4e-157 63
iucA YP_001399703.1 aerobactin siderophore biosynthesis protein IucA VFG1081 Protein 2e-139 59