Gene Information

Name : YpsIP31758_3832 (YpsIP31758_3832)
Accession : YP_001402786.1
Strain : Yersinia pseudotuberculosis IP 31758
Genome accession: NC_009708
Putative virulence/resistance : Virulence
Product : sensor histidine kinase/response regulator EsrA
Function : -
COG functional category : T : Signal transduction mechanisms
COG ID : COG0642
EC number : -
Position : 4311670 - 4314489 bp
Length : 2820 bp
Strand : +
Note : identified by similarity to GB:AAV69423.1; match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF01627; match to protein family HMM PF02518

DNA sequence :
ATGGGCAAAGCATCATCACTTGTCACTCGATTGACATTATTACTGGGCGTCACACTAACCGTTATTTGGTTAATATTAAT
CGCAACAACAGCATTCTTTTCATATGAAAATACACGTCAAATATTAATCAATGAGTTAACACATATGGCATCGATGCGGG
CAGACTTAAGTAATCACCAGTTTGAAGGAGCTGAACGTGATGCAGCCTCGTTAATAAGCCGACGAGAAAGCCTCCAGAGC
ACCTCACCGTTGCCTGAAATATCGATAAAACATTATGATAGCTGCTATATTCCTTTTAATCTGGACAGCTGTAATATTAA
CCAACATAAAAATGATCTGTGGATAATTCAAGCGTATGGCACCGCCGGGCAAACTTATTATCTCGACAGTTTTATTATCA
AACAAAAAGAGGGGATTGTGTTATTCCCACCCCAAAAATCATCGAGTGATTACCTAAATCAACGGCGCAAAGATTTACTT
TTGCTCCCCAAATTCCCTACTCACAATAATATCTATTGGGGAGCCCCCACCTATACGCCTCAAGGTGGCTGGCATGTTTC
TGTCGCGGTGTGTGATAAAGTGGGCACCTTGGCTGGCTTCGCCTTAAAACTGAATGATCTCATCGCCTATAATCACCCTG
TCGAGCAAAGAGACATTAATTTATTGTTGGATAAGAATGGTGAATTATTACCTATTTCCCAGCAAGCAACATCATCAAAT
CAACTACATGAAATTCTTAACCAACTCAAAAACAGTAAATTACACGATGGCTGGCAGCAAACTCCCGACTATTTGGTATT
ACGCACCCAATTGAAAGGGCCGGGTTGGCAGCAATTAGTTATTTATCCACGAATAGGCTTTGCCTGGGAGGCACTGAAAC
CCGCCTTATATCAACTCCCTTTCGCTCTGGTTATTTTGCTGTTACTCACGTCAGTGCTGTCACTGCTGCTGCGATATTAT
CTGGCGATCCCTTTGTGGAATTTCATCAATATCATTGGCGCTACCGGGCCACAGGCAATGGAACCCCGACTTCCCATAAA
CCGAATAGATGAATTAGGGCATATTGCCCGCGCTTACAATAACTTACTGGATACGTTGAACGAACAATATGACACCTTAG
AAATGAAAGTGAAGGAGCGTACTCTGGCTCTGGCAAAAGCCAAACGAGCTGCTGAGCAGGCTAACCGCCGTAAAAGCGAC
CATCTAACCACGATCAGCCATGAAATCCGTACACCGCTCAACGGGGCGTTGGGGGCGGTTGAATTATTACAAAATACACC
ACTGGATGCTGGCCAAATGAGGTTAGCGGAAACGGCCCACCAATGTTCGTTATCACTGCTCGCGATCATTAACAACCTGT
TAGATTTTTCACGTATTGAATCAGGGCAAATGACACTGTCGCTGAAGAAAACGGCCCTACTGCCTTTACTGGATCAGGCG
ATGTTAACCATTCATAGCCAGGCACTGAGTAAGTCATTAGCGCTGTCCACGTTTATCAGTGCCGATATCCCGCTGGAACT
TGAGCTGGATACACTGCGCTTAAGACAGATTCTGGTTAATTTATTAGGTAATGCCGTTAAATTCACACCACAGGGCCGTA
TTCAACTCAGGGTCAGGCGTCAAAACCAAACGCTTTGTTTTACCGTTGAGGACACCGGTTGTGGTATTGACGTGCAACAT
CAACAAACAATATTCCAACCATTTATGCAGACCAGTGACCATGAACAAGGAACGGGTCTGGGGCTGGCTATCGCAGATAA
TCTGGCCAAAATGATGGGGGGCCACCTGACAGTATTCAGTGAACCGGGTCAAGGTAGCTGTTTTTCATTATGTCTCCCCT
TCAATGCAATCACCCCGCCAATACCTTTTCATGGCGAGCTATTCGCACCACAACGCTTACATGCCCAATTATCAGCCTGG
GGCATGACCTGCCAGCCAGAATTAACTAATCAGCCATCACGGCACTTTGTGGATAACGCATTGTGTTACTTACCCGGCCG
GTTATACACCAACCTGAAGCAATATCTACAAGGTGCTGAGACTGAGGCGCTAAAGAGCCTTCCGCTGCAACCTTGGCAGA
TGCACATTCTGCTGGTTGATGACTCCGAAACGAATCGCGATATTACCGGAATGATGTTGCAGCAACTGGGGCATCAGGTC
ACGCGGGCAGACAGTGGCACAACCGCATTGGCGATTGGCCGCCAGCATCGTTTCGATTTAGTGCTAATGGATATTCGAAT
GCCTGTTCTGGACGGGCTGGCCACCACGGCACGCTGGCGTCATGATCCGGCGAACATTGATAGCCACTGCATGATCACCG
CCCTGAGCGCCAATGCCAGCCCGGATGAGCAAATCAAAACCAATCAGGCGGGGATGAACCACTACCTTTCCAAGCCTGTC
ACCCTCGGCCAATTGGCTGAAATGTTAGATCTGACCGCACAATTCCAACTTGAGCGTGGGGTCGATCTATCGCCACAACT
CTCCGAGCCTCAGCCATTACTGGATCTCGCGGATAGCGCGTTGTCCCTGAAACTTTATCAATCACTGCAAGTATTAATTC
AACAGGCCAAAGACGCTATTGAGAACTTGCCCGTATTATCCCATACGCTTCACACCATAAAAGGCTGTGCCGGGCAAGCT
GGGCTAATTGAATTACAAGATGCGGTCATTCAATTAGAACACGCTCTCGATACTCATGAAACGCTGACACAGCAAGATAT
CATTCACCTTGATGAAATAATTCATGTGCTGCTACAGCCACCCACTACATGCGAATCCACGTTTATCATCAGCCAGGGCC
AGTCCCTTATGGTTAAATAA

Protein sequence :
MGKASSLVTRLTLLLGVTLTVIWLILIATTAFFSYENTRQILINELTHMASMRADLSNHQFEGAERDAASLISRRESLQS
TSPLPEISIKHYDSCYIPFNLDSCNINQHKNDLWIIQAYGTAGQTYYLDSFIIKQKEGIVLFPPQKSSSDYLNQRRKDLL
LLPKFPTHNNIYWGAPTYTPQGGWHVSVAVCDKVGTLAGFALKLNDLIAYNHPVEQRDINLLLDKNGELLPISQQATSSN
QLHEILNQLKNSKLHDGWQQTPDYLVLRTQLKGPGWQQLVIYPRIGFAWEALKPALYQLPFALVILLLLTSVLSLLLRYY
LAIPLWNFINIIGATGPQAMEPRLPINRIDELGHIARAYNNLLDTLNEQYDTLEMKVKERTLALAKAKRAAEQANRRKSD
HLTTISHEIRTPLNGALGAVELLQNTPLDAGQMRLAETAHQCSLSLLAIINNLLDFSRIESGQMTLSLKKTALLPLLDQA
MLTIHSQALSKSLALSTFISADIPLELELDTLRLRQILVNLLGNAVKFTPQGRIQLRVRRQNQTLCFTVEDTGCGIDVQH
QQTIFQPFMQTSDHEQGTGLGLAIADNLAKMMGGHLTVFSEPGQGSCFSLCLPFNAITPPIPFHGELFAPQRLHAQLSAW
GMTCQPELTNQPSRHFVDNALCYLPGRLYTNLKQYLQGAETEALKSLPLQPWQMHILLVDDSETNRDITGMMLQQLGHQV
TRADSGTTALAIGRQHRFDLVLMDIRMPVLDGLATTARWRHDPANIDSHCMITALSANASPDEQIKTNQAGMNHYLSKPV
TLGQLAEMLDLTAQFQLERGVDLSPQLSEPQPLLDLADSALSLKLYQSLQVLIQQAKDAIENLPVLSHTLHTIKGCAGQA
GLIELQDAVIQLEHALDTHETLTQQDIIHLDEIIHVLLQPPTTCESTFIISQGQSLMVK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
YPO0256 YP_002345336.1 two-component sensor/regulator Not tested Not named Protein 0.0 99
spiR AAC44299.1 SpiR Virulence SPI-2 Protein 3e-135 46
ssrA NP_456136.1 putative two-component sensor kinase Virulence SPI-2 Protein 1e-142 45
ssrA NP_805063.1 two-component sensor kinase Virulence SPI-2 Protein 6e-143 45
ssrA YP_216400.1 secretion system regulator:sensor component Virulence SPI-2 Protein 5e-143 44
ssrA NP_460357.1 sensor kinase Virulence SPI-2 Protein 4e-142 44

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
YpsIP31758_3832 YP_001402786.1 sensor histidine kinase/response regulator EsrA VFG0493 Protein 2e-142 44