Gene Information

Name : guaA (NIS_1339)
Accession : YP_001356804.1
Strain : Nitratiruptor sp. SB155-2
Genome accession: NC_009662
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1350082 - 1351632 bp
Length : 1551 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGCAAGAAGTACCTATAGTTATTTTAGATTTTGGGAGTCAATATACGCAACTCATAGCTAGACGCTTAAGAGAGGTTGG
GGTATATTGTGAGATATATCCCTTTTTTGAACCGATAGAAAATATTAGGGCTAAAAAGCCTCAAGGTATCATTCTCAGCG
GTGGACCGGCGAGCGTCTATGAACCGGATGCTCCAAGAGTGGATAAGGCAATTTATGAACTTGGCATTCCCGTGCTTGGT
ATATGCTATGGAATGCAGCTTATTACAGTCGATTTCGGTGGTCAAGTGGTACGGGCTTTGGAACATGAGTATGGAAAAGC
GAAACTCTATTTCGATCCAATTCATGGTAAAGTCTGTCCGCTCTTTGAAGGTACAAAGGATGGGCAGATTGTTTGGATGA
GTCATGGAGACAAAGTAACAGAATTACCAGCGGGTTTTATAAGAATTGCTCATACCGATAATTCTCCTTACGCAGCTATA
GCGAATGAAGAGAAACAGATCTATGCTTTGCAGTTTCATCCGGAAGTTTCACACTCCCAAGAGGGACAGAAAATTCTAGA
AAATTTTGCAAGAAAAATATGTGGTATTACAAGCAAATGGGATATGGGCCATTTTGCAAAAGAGCAGATCGAAAAGATCC
GGCAAAGAGTGGGTGAAGATAAAGTACTTTGTGCTTTGAGCGGTGGAGTAGATAGTTCTGTCGTTACAGCACTTTTATAC
GAAGCGATAGGGGATAAACTTATTCCCGTTTTTGTAGACAACGGACTTTTGCGAGAGGGTGAGAGAGAGAAAGTGGAGTA
TGTATTCAAAAATATGCTCAAAGTTCCACTTATAGTCGTTGATGCCAAAGAGCGGTTTTTAAATGCTTTACAAGGCATCA
CCGATCCAGAGCAGAAGCGAAAGATCATCGGTCACACATTTATCGAAGTTTTTGAAGAAGAAGCGAAAAAACATACTGAC
GTAAAATATCTTGCTCAAGGAACCTTGTATCCCGATGTGATCGAATCCGTTTCTGTGAAAGGTCCAAGCGAAACAATCAA
GTCACATCATAATGTCGGTGGGCTTCCCGACTGGATGAAATTTGAACTTATTGAGCCTTTGAGAGAGCTTTTTAAAGATG
AGGTACGAAAACTCGGCCTGGAACTCGGTCTTCCGAGAGAGATGGTCTATCGCCATCCATTCCCAGGACCAGGTTTGGCG
ATCAGGATACTTGGAGAAGTGAACGAAGAGGCTTTGGATCTTGTTCGCAAAGCCGATACGATTTTGCTTGAAGAGATCAA
AGCCCATGGCCTTTATGAAAAATTGTGGCAGAGTTTTGCCGTGCTGCTCAATGTCAAAAGTGTTGGTGTGATGGGAGATA
AAAGAACCTACGAAAATACCGTTGCACTCCGTATCGTAGAAAGTAGTGATGGCATGACGGCAACATTTGCCCATATCCCT
CACGATTTATTGGAGCTCATTTCCAATAGAATCATTAACGAAGTGGACGGGATCAATAGAGTTGTATATGATATCACTTC
CAAGCCACCAGGAACCATTGAGTGGGAATAA

Protein sequence :
MQEVPIVILDFGSQYTQLIARRLREVGVYCEIYPFFEPIENIRAKKPQGIILSGGPASVYEPDAPRVDKAIYELGIPVLG
ICYGMQLITVDFGGQVVRALEHEYGKAKLYFDPIHGKVCPLFEGTKDGQIVWMSHGDKVTELPAGFIRIAHTDNSPYAAI
ANEEKQIYALQFHPEVSHSQEGQKILENFARKICGITSKWDMGHFAKEQIEKIRQRVGEDKVLCALSGGVDSSVVTALLY
EAIGDKLIPVFVDNGLLREGEREKVEYVFKNMLKVPLIVVDAKERFLNALQGITDPEQKRKIIGHTFIEVFEEEAKKHTD
VKYLAQGTLYPDVIESVSVKGPSETIKSHHNVGGLPDWMKFELIEPLRELFKDEVRKLGLELGLPREMVYRHPFPGPGLA
IRILGEVNEEALDLVRKADTILLEEIKAHGLYEKLWQSFAVLLNVKSVGVMGDKRTYENTVALRIVESSDGMTATFAHIP
HDLLELISNRIINEVDGINRVVYDITSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 3e-145 58
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-145 58
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-145 58
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-124 51