Gene Information

Name : ureC (mma_1814)
Accession : YP_001353504.1
Strain : Janthinobacterium sp. Marseille
Genome accession: NC_009659
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : 3.5.1.5
Position : 2046122 - 2047822 bp
Length : 1701 bp
Strand : +
Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp

DNA sequence :
ATGAGCAAGATATCGCGTCAGGCTTATGCCGAAATATTCGGCCCGACCACCGGCGACCGTTTGCGTTTGGCAGATACCGA
ATTATTCATTGAAATCGAAAAGGACTTCACCACCTACGGCGAAGAAGTGAAGTTCGGCGGCGGCAAGGTGATTCGCGACG
GCATGGGCCAGTCGCAACGCAATTACAAGGATGTGATGGATACCGTCATCACGAATGCCGTCATCGTCGAACATTGGGGT
ATCGTTAAAGCCGATATCGGCCTCAAGGGCGGCAAGATTGCCGGCATCGGCAAGGCCGGTAATCCGGACATCCAGCCGGA
TGTCACGATGGCAATTGGCGGCGCCACTGAAATCATCGCCGGCGAAGGCATGATCGTCACGGCCGGCGGCGTGGATACCC
ACATCCACTTCATTTGCCCGCAACAGATAGAAGAAGCATTGATGAGCGGCGTCACCACCATGATAGGCGGCGGCACCGGC
CCCGCTGTCGGCACTGCCGCCACCACCTGTACGCCCGGCCCCTGGCATATCCATTCGATGTTGTCGGCGGCCGATGCCTT
CCCGATGAACCTGGGTTTCCTCGGCAAAGGCAATGTCAGCCTGCCGACGCCATTGGAAGAACAGATCCACGCCGGTGCCA
TCGGCCTCAAGCTGCATGAAGACTGGGGTTCGACCCCGGCCGCAATCGACAATTGCCTGTCAGTTGCAGACCGCCTCGAC
GTGCAAGTGGCGATCCATAGCGATACCTTGAACGAAGGTGGTTTCCTCGAACACACACTGGCCGCCTTCAAGGATAGAAC
TATCCACACTTTCCATACCGAAGGTGCCGGCGGCGGCCATGCGCCCGACATCATCGCCGCCGTCGGCCAGGCCAATGTCT
TGCCGTCCTCCACCAATCCGACCCGGCCCTTTACTGTCAATACGCTGGATGAGCATCTGGACATGCTGATGGTCTGCCAT
CACCTGGATCCTGCGATTGCCGAAGACGTCGCCTTCGCCGAATCCCGTATCCGGCGCGAAACGATAGCCGCCGAAGACAT
CCTGCATGACATCGGCGCGATCTCGATGATGTCGTCCGATTCGCAGGCCATGGGACGGGTCGGCGAAGTCATCATGCGCA
CCTGGCAAACCGCACACAAAATGAAGGTGCAGCGCGGCTCACTGGCAGGCGACCCGGCGCGCAATGACAACTTCCGCGTC
AAACGCTATATCGCCAAATACACCATCAACCCGGCCATCACGCATGGGATTTCACATGTGGTCGGCTCGCTCGAAGTCGG
CAAGGTGGCCGATATCGTCCTGTGGAAACCGGCCTTCTTCGGCGTCAAGCCATCGATGATCCTGAAAAGCGGGATGATTG
CCGCGGCCCAGATGGGTGATCCGAATGCCTCGATCCCGACGCCGCAACCGGTGCATTACAGGATGATGTTCGGTGCCTAT
GGCGGCGGCCTGAAGACATCGATGACCTTCGTCTCACAATCAGCCTTTGATGCCGGCATAGGCGACATGCTGAAACTGAA
CAAGCCGGTGGTCGCAGTCAAGAATATGCGTCATCTGCGCAAACGCGACATGATCCACAACAGCGCGACGCCGAAAATGG
AAGTCGATTCGGAAACCTATGAAGTGCGTGCCGATGGCGAGCTGCTGGTATGTGAACCGGCCAAGATCCTGCCTCTGGCA
CAACGCTACTTTTTATTTTAA

Protein sequence :
MSKISRQAYAEIFGPTTGDRLRLADTELFIEIEKDFTTYGEEVKFGGGKVIRDGMGQSQRNYKDVMDTVITNAVIVEHWG
IVKADIGLKGGKIAGIGKAGNPDIQPDVTMAIGGATEIIAGEGMIVTAGGVDTHIHFICPQQIEEALMSGVTTMIGGGTG
PAVGTAATTCTPGPWHIHSMLSAADAFPMNLGFLGKGNVSLPTPLEEQIHAGAIGLKLHEDWGSTPAAIDNCLSVADRLD
VQVAIHSDTLNEGGFLEHTLAAFKDRTIHTFHTEGAGGGHAPDIIAAVGQANVLPSSTNPTRPFTVNTLDEHLDMLMVCH
HLDPAIAEDVAFAESRIRRETIAAEDILHDIGAISMMSSDSQAMGRVGEVIMRTWQTAHKMKVQRGSLAGDPARNDNFRV
KRYIAKYTINPAITHGISHVVGSLEVGKVADIVLWKPAFFGVKPSMILKSGMIAAAQMGDPNASIPTPQPVHYRMMFGAY
GGGLKTSMTFVSQSAFDAGIGDMLKLNKPVVAVKNMRHLRKRDMIHNSATPKMEVDSETYEVRADGELLVCEPAKILPLA
QRYFLF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 3e-171 71
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 3e-171 71
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-151 63
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-151 63
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 2e-151 63
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-151 63

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ureC YP_001353504.1 urease subunit alpha VFG0270 Protein 2e-147 62