Gene Information

Name : PSPA7_4465 (PSPA7_4465)
Accession : YP_001349815.1
Strain : Pseudomonas aeruginosa PA7
Genome accession: NC_009656
Putative virulence/resistance : Unknown
Product : plasmid DNA topoisomerase I
Function : -
COG functional category : L : Replication, recombination and repair
COG ID : COG0550
EC number : 5.99.1.2
Position : 4594820 - 4596739 bp
Length : 1920 bp
Strand : +
Note : Omega-protein; Relaxingenzyme; Untwisting enzyme; Swivelase; Annotation was generated automatically without manual curation; identified by match to protein family HMM PF01131

DNA sequence :
ATGCACCTCGTAATCATTGAAGCCCCGGGCAAGCTGAAAAAGCTGAGGTCCCTTCTCCCCTCGATTCGTCCCGACGTGAC
CTGGCAGGTCGAGGCGACAGCCGGCCACATCAGAGACCTACCCGTTCACGGCCAGGATCCGCAGATGCTCACCGTCGGCG
TGGGCCAGGATTTCAAACCGCACTACCAGATCCTCTCGGGCAAGGAAAAAGCCGTCGCACGGCTGAAGGATCTGCAGCAG
AAAGCTCTGGAGATCTACGTCGCATCCGACCCGGATCGCGAAGGCGAAAGCATCGGCTGGCACATACTCCAGGCTGCCGG
GATCAAGAACTACAAGCGCGTTGCCTTCAAGGAAATCACCAAGTCATGCATCAGCGCCGAACTCAGCTCGCCGCGTCGCC
TGGACCTCCCGAAGGTCGCCTCGCAGGAATGCCGTCGCGTCATCGATCGCCTGGTGGGGTATCTGGTCACGCCAGAGTTG
CGGCGCGTGATGGGCAGGCCAACCACCGCCGGGCGCGTGCAGTCCGTCGCTGTGTACCTGGTGGTCCTGCGAGAGCGGGA
GATTCGCGCCTTCACACCAATCAAGCATTTCGGGGTGGAACTGGCCTTCGTTTCGCCCAGCGACGGCCGCACCTGGAAGG
CGGAGTGGGATCCAGTGCCCACGTTTGCCAGCAAGGAATTTCCGTATATCCAGGATCGTCAACTCGCAGAACTGGTGGGG
GCTATACGCAATGTGATCGTCGAGACCTGCATTGATGGCGAAGAAACCGATATGCCTCCGGCGCCGTTCATCTCCTCTTC
GCTCCAGATGGCAGCCGGAAATGCACTGAAGTGGTCACCCGACAAGACGATGAAAGTCGCCCAGCGGCTGTATGAACAGG
GGCTCATCACTTACCACCGAACGGACAACCCCAATATTTCGAAGGACTCGATGCCGGATATCCGTGCTGTCGCCAAAGCC
TTGGGGCTGAAGTGTGTAGAGCAACAGCGAATGTTCAAAGCGGACCAAGACGCTCAGGAAGGCCACCCCGCCATCACCCC
TACCGACTGGATGGCCGCTACCGCCGGTGAAACTGCTGATGAGCAGGCGCTGTACCAGCTCATTCGAGTTCGCGCGCTTG
CCAGCCAGATCGAAGCTGCCGTGTACGCAGTGAGAACCATCACCCTCCTGGGCGTCGGCCCCGACAAAAAGCCACTGCGC
TTCGGCGCCAAAGGGAAGCTGTTGAACGTGCCTGGATGGAGAAAACTGCTGCAGGGCGATGATGCCGAGGAGCAAAAGAA
CGAAACGCCTTCAAGCCCCATCCCGGCGCTGGAGCCAGGCCAGATACTCAAGGTCTACAGCGGCGAGGTCCTGGAGAAGA
AAACCACCCCTCCCAAACGCTTCACCGATGCCAGCCTGGTGGGCGAGATGAAGCGCCGCGGGATTGGTCGGCCATCCTCC
TACGCCTCGATCGTGAAGAACATCATCGACAAGGGCCAGGTGCAGATGAAGGGCCGAAGCCTGATCCCCGGCGAGCTGGG
CGAGGCCACCATAGCGCTCCTGGAGCACAACTTCAGCTTCCTCAGCCTCGACTTCACCCGCAACCTCGAGGTCGCCCTGG
ACCGGATCGCCAACAGCGAGGACACCTACATGAACGTGGTCCAGCAGTTCTACCAGCTCCTGCAGTCAGAGCTGCAGACG
CTGCGCGCGCTCCCCAGCGCACAGGGCGACCCGCGAGCAAGCTCTACCGCCAGCGCTCCCTCGGCGCCGGCCAGTGACTT
CCTCTGCGGCAAGTGCGGTCTGCCCCTGGTCCACCGAAAGAAAGCCGGCAAGGGCGGCTTCGACTTCTGGGGTTGCAGCG
GCTATCGCAGCACCGGCTGCAAAGTCAGCTACCCCACCAAGGACGGCCAACCTGACTTCGACAACCCGCGCGGGCTATAG

Protein sequence :
MHLVIIEAPGKLKKLRSLLPSIRPDVTWQVEATAGHIRDLPVHGQDPQMLTVGVGQDFKPHYQILSGKEKAVARLKDLQQ
KALEIYVASDPDREGESIGWHILQAAGIKNYKRVAFKEITKSCISAELSSPRRLDLPKVASQECRRVIDRLVGYLVTPEL
RRVMGRPTTAGRVQSVAVYLVVLREREIRAFTPIKHFGVELAFVSPSDGRTWKAEWDPVPTFASKEFPYIQDRQLAELVG
AIRNVIVETCIDGEETDMPPAPFISSSLQMAAGNALKWSPDKTMKVAQRLYEQGLITYHRTDNPNISKDSMPDIRAVAKA
LGLKCVEQQRMFKADQDAQEGHPAITPTDWMAATAGETADEQALYQLIRVRALASQIEAAVYAVRTITLLGVGPDKKPLR
FGAKGKLLNVPGWRKLLQGDDAEEQKNETPSSPIPALEPGQILKVYSGEVLEKKTTPPKRFTDASLVGEMKRRGIGRPSS
YASIVKNIIDKGQVQMKGRSLIPGELGEATIALLEHNFSFLSLDFTRNLEVALDRIANSEDTYMNVVQQFYQLLQSELQT
LRALPSAQGDPRASSTASAPSAPASDFLCGKCGLPLVHRKKAGKGGFDFWGCSGYRSTGCKVSYPTKDGQPDFDNPRGL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
unnamed ABR13436.1 DNA topoisomerase I Not tested PAGI-5 Protein 0.0 99
topA AAP84217.1 topoisomerase I Not tested PAPI-1 Protein 0.0 96
top ACP28824.1 DNA topoisomerase I Not tested AbaR5 Protein 2e-109 45
topA ADI24145.1 DNA topoisomerase I Not tested AbaR1 Protein 1e-109 45