Gene Information

Name : guaA (Asuc_0896)
Accession : YP_001344201.1
Strain : Actinobacillus succinogenes 130Z
Genome accession: NC_009655
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : -
Position : 960801 - 962372 bp
Length : 1572 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGGACAACATTCACAACCATAAAATCTTAATCCTCGACTTCGGTTCACAATATACCCAACTGATCGCACGCCGTGTGCG
CGAAATCGGGGTTTACTGCGAACTTTGGGCGTGGGACGTAACGGAGCAACAAATCCGTGAATTTAACCCGACCGGGATTA
TCCTTTCCGGCGGCCCGGAAAGTACCACGGAAAATGACAGTCCGCGAGCGCCGGAATATGTATTCGACGCCGGCGTGCCG
GTGCTAGGTGTGTGTTACGGCATGCAGACTATGGCGATGCAGCTTGGCGGGTTAACCGAAGGTTCGGCTCATCGAGAATT
CGGTTATGCACAAGTGGATTTACAGGCAACGGACAGTTTATTCGCACAATTAAATGATGATTTAGATTCAGCTCAACCGA
AATTAGACGTTTGGATGAGCCATGGTGATAAAGTAACCCGTTTACCGGAAGGTTTTCAGGTGACCGGAACCACACCGACT
TGTCCGATCGCCGCGATGTCCGACGAAAAGCGTCATTTCTACGGTGTACAGTTCCATCCGGAAGTCACCCATACCAAAAG
CGGTTTAGCGTTGTTAACTAATTTCGTTGTTAACATTTGTGGTTGTGCCACCAACTGGACGCCTGAAAATATTATCGAGG
ACGCTGTTGCCCGTATTAAAGCGCAAGTGGGCGACGATGAAGTGATTTTAGGGTTATCGGGCGGCGTGGATTCCTCCGTT
ACCGCATTGTTATTACATCGTGCCATCGGCAAAAATCTGCACTGCGTATTCGTGGATAACGGTTTATTACGTCTTAACGA
AGGCGACCAAGTGATGGAAATGTTCGGTGATAAATTCGGTTTGAACATTATTCGCGTAAATGCGGAAGAACGCTTCTTAG
ACGCTCTGAAAGGTATTCACGATCCGGAAGCTAAACGTAAAATGATCGGCAAAGTATTTGTGGACGTATTCGACGAAGAA
TCTCACAAACAAACCAGCGTTAAATGGTTGGCGCAAGGTACGATTTACCCGGATGTAATCGAATCCGCCGCCAGTAAAAC
CGGCAAAGCTCACGTAATCAAATCGCACCACAATGTCGGCGGTTTGCCGGATTATATGAAACTCGGCTTGGTCGAGCCGT
TGCGTGAATTGTTCAAAGACGAAGTACGCAAAATCGGCTTGGCACTCGGCTTACCTGCCGAAATGCTCAACCGCCACCCG
TTCCCGGGTCCCGGTTTAGGTGTACGTGTATTGGGTGAAATCAAAAAAGAATATTGCGATTTACTGCGTAAAGCCGACGC
CATTTTCATCGAAGAATTGTACAACTCGGGCTGGTACTACAAAGTGAGCCAAGCATTCACCGTATTCCTACCGGTGAAAT
CGGTCGGTGTGATGGGCGACGGGCGTAAATACGACTGGGTGGTCAGTTTACGTGCAGTAGAAACCATCGATTTTATGACC
GCACATTGGGCGCAGCTGCCGTATGATTTATTAGGTAAAATCTCCAACCGCATTATCAACGAAGTAGACGGCATTTCCCG
CGTGGTGTATGACGTCAGCGGAAAACCGCCAGCAACGATTGAGTGGGAGTAG

Protein sequence :
MDNIHNHKILILDFGSQYTQLIARRVREIGVYCELWAWDVTEQQIREFNPTGIILSGGPESTTENDSPRAPEYVFDAGVP
VLGVCYGMQTMAMQLGGLTEGSAHREFGYAQVDLQATDSLFAQLNDDLDSAQPKLDVWMSHGDKVTRLPEGFQVTGTTPT
CPIAAMSDEKRHFYGVQFHPEVTHTKSGLALLTNFVVNICGCATNWTPENIIEDAVARIKAQVGDDEVILGLSGGVDSSV
TALLLHRAIGKNLHCVFVDNGLLRLNEGDQVMEMFGDKFGLNIIRVNAEERFLDALKGIHDPEAKRKMIGKVFVDVFDEE
SHKQTSVKWLAQGTIYPDVIESAASKTGKAHVIKSHHNVGGLPDYMKLGLVEPLRELFKDEVRKIGLALGLPAEMLNRHP
FPGPGLGVRVLGEIKKEYCDLLRKADAIFIEELYNSGWYYKVSQAFTVFLPVKSVGVMGDGRKYDWVVSLRAVETIDFMT
AHWAQLPYDLLGKISNRIINEVDGISRVVYDVSGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-129 54
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-129 54
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-129 54
guaA NP_938969.1 GMP synthase Not tested Not named Protein 9e-111 47