Gene Information

Name : murD (KPN_00092)
Accession : YP_001333782.1
Strain : Klebsiella pneumoniae subsp. pneumoniae MGH 78578
Genome accession: NC_009648
Putative virulence/resistance : Unknown
Product : UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG0771
EC number : -
Position : 108826 - 110142 bp
Length : 1317 bp
Strand : +
Note : UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation

DNA sequence :
ATGGCAGATTATCAGGGTAAAAAAGTCGTCATTATTGGGCTGGGTATGACCGGCCTGTCATGCGTGGACTTTTTCATGGC
GCGCGGCGTAACCCCGCGCGTGATGGACACCCGCGTCGCGCCTCCGGGGCTGGATAAATTACCCGAATCGGTCGAATGCC
ATGTCGGCGGACTCAATGATACCTGGCTGCTGGCGGCGGACCTGATTGTCGCCAGTCCGGGGATTGCGCTGGCCCATCCT
TCGCTCAGCGCAGCGGCCGACGCTGGCGTAGAGATCGTTGGCGATATCGAACTGTTCTGCCGCGAAGCGCAGGCGCCGAT
TATCGCCATTACCGGTTCTAACGGCAAAAGCACTGTTACTACCCTGGTGGGCGAGATGGCGAAAGCCGCTGGAGTTAACG
TCGGCGTGGGCGGCAATATCGGCCTGCCGGCGCTGATGCTGCTGGACACCGATCGAGAGCTGTATGTGCTGGAGCTCTCC
AGCTTCCAGCTGGAAACCACCTCCAGCCTGCAGGCGGTGGCGGCAACCATCCTCAACGTGACTGAGGACCATATGGACCG
CTACCCGCTGGGGCTGCAGCAGTATCGCGCGGCGAAGCTGCGGATTTACGAGAATGCGAAGACCTGCGTGGTGAACGCGG
ACGATGCGCTCACCATGCCGGTACGCGGGGCGGACGAACGCTGCATTAGCTTTGGCGTCGATGTCGGTGACTACCACCTT
AACCGCCAGCAGGGCGAAACCTGGCTGCGCGTTAAAGGTGAGAAAGTCCTCAATGTGAAAGAGATGCCTCTCACCGGTCA
GCATAACTACAGCAACGCCCTGGCGGCGCTGGCGCTGGCCGATGCCGCGGGTCTGCCGCGGGCCAGCAGCCTGAAGGCGC
TGACCACCTTTACCGGTCTGGCGCACCGTTTCCAGCTGGTGCTGGATCACAACGGCGTACGCTGGATTAACGACTCGAAG
GCGACCAACGTCGGCAGCACCGAGGCGGCGCTGAACGGCCTGCAGCTGGACGGCACGCTCTATCTGCTGCTTGGCGGCGA
CGGCAAGTCCGCTGATTTCACCCCGCTGAAGCGCTACCTCGGCGGCGATCGTATTCGCCTGTACTGCTTTGGTCGCGATG
GCGCCGAGCTCGCTGAGCTGCGTCCTGAGGTGGCGGTACAAACTGAGACTATGGAACAGGCGATGCGTCAGATTGCTCCC
CTGGTGAAAGCGGGGGACATGGTGCTCCTGTCGCCGGCCTGCGCCAGCCTGGATCAGTTTAAGAACTTTGAACAACGGGG
CGAGATGTTTGCCCGTCTGGCGAAGGAGTTAGGTTGA

Protein sequence :
MADYQGKKVVIIGLGMTGLSCVDFFMARGVTPRVMDTRVAPPGLDKLPESVECHVGGLNDTWLLAADLIVASPGIALAHP
SLSAAADAGVEIVGDIELFCREAQAPIIAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDTDRELYVLELS
SFQLETTSSLQAVAATILNVTEDHMDRYPLGLQQYRAAKLRIYENAKTCVVNADDALTMPVRGADERCISFGVDVGDYHL
NRQQGETWLRVKGEKVLNVKEMPLTGQHNYSNALAALALADAAGLPRASSLKALTTFTGLAHRFQLVLDHNGVRWINDSK
ATNVGSTEAALNGLQLDGTLYLLLGGDGKSADFTPLKRYLGGDRIRLYCFGRDGAELAELRPEVAVQTETMEQAMRQIAP
LVKAGDMVLLSPACASLDQFKNFEQRGEMFARLAKELG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00311 YP_008207776.1 UDP-N-acetylmuramoylalanine-D-glutamate ligase Not tested AbaR25 Protein 1e-51 43
BJAB0868_00315 YP_008211641.1 UDP-N-acetylmuramoylalanine-D-glutamate ligase Not tested AbaR26 Protein 1e-51 43