Gene Information

Name : cadB (KPN_00499)
Accession : YP_001334179.1
Strain : Klebsiella pneumoniae subsp. pneumoniae MGH 78578
Genome accession: NC_009648
Putative virulence/resistance : Virulence
Product : lysine/cadaverine antiporter
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0531
EC number : -
Position : 546709 - 548043 bp
Length : 1335 bp
Strand : +
Note : antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein

DNA sequence : 
ATGAGTTCTGCCAAGAAGATCGGGCTATTTGCCTGTACCGGTGTCGTCGCCGGTAATATGATGGGGAGCGGGATTGCATT
ATTACCTGCGAACCTGGCCAGCATCGGTGGTATTGCCATTTGGGGCTGGGTAATTTCAATTATTGGTGCGATGTCTCTGG
CTTATGTTTATGCCCGACTGGCCACTAAAAACCCGCAGCAGGGCGGTCCTATTGCCTACGCTGGCGAAATATCTCCGGCA
TTCGGTTTCCAGACCGGCGTCCTTTATTATCATGCAAACTGGATTGGTAACCTGGCCATCGGGATTACCGCAGTTTCTTA
TCTCTCTACGTTCTTCCCAATTTTAAATAACCCGGTGCCAGCAGGTATTGCCTGTATTGCCATCGTGTGGATCTTTACTT
TCGTTAATATGCTCGGCGGGACCTGGGTCAGCCGTCTGACCACCATTGGTCTGGTACTGGTGCTTATTCCGGTAGTCATG
ACCGCGGTCGTCGGCTGGCACTGGTTTGATGTCGCTACCTATCAGGCGAACTGGAATACCTCCAGCACCACCGATAGCCA
CGCGGTTATTAAAAGTATCCTGCTCTGCCTGTGGGCCTTCGTTGGCGTAGAATCCGCCGCCGTGAGTACCGGGATGGTGA
AAAACCCGAAACGTACCGTGCCGCTGGCAACCATGCTGGGTACCGCGATGGCCGGTATCGTCTACATCGCCGCGACTCAG
GTTATCGCCGGTATGTATCCTGCTTCTCAGATGGCCGCGTCCGGTGCGCCGTTCGCAATTAGCGCCTCTACCATCCTCGG
CGGCTGGGCTGCACCGATGGTATCCGCTTTCACCGCCTTTGCCTGCCTGACTTCTCTGGGCTCGTGGATGATGCTGGTTG
GCCAGGCCGGTGTGCGTGCCGCCAACGACGGTAACTTCCCGAAAGTGTATGGCGAAGTTGATAACAACGGTATTCCGAAA
AAAGGCCTGCTGCTGGCCGCAGTGAAAATGACCGCGCTGATGGTGCTGATTACCCTGATGAACTCCGCCGGTGGTAAAGC
CTCTGACCTGTTCGGCGAACTGACCGGTATCGCGGTACTGCTGACCATGCTGCCTTACTTCTACTCCTGTGTTGACCTGA
TTCGTTTCGAAGGCATCAACATCCGTAACTTCGTTAGCCTGATTTGTTCGGTACTGGGTTGCGTGTTCTGCTTCATCGCG
CTGATGGGCGCAAGCTCCTTCGAACTGGCCGGCACCTTCATCGTTAGCCTGATTATCCTGATGTTCTACGGCCGCAAAAT
GCACCAGCGCCAGAACAACGCATCGGATAACAACACCACCGCTAACGCGCACTAA

Protein sequence : 
MSSAKKIGLFACTGVVAGNMMGSGIALLPANLASIGGIAIWGWVISIIGAMSLAYVYARLATKNPQQGGPIAYAGEISPA
FGFQTGVLYYHANWIGNLAIGITAVSYLSTFFPILNNPVPAGIACIAIVWIFTFVNMLGGTWVSRLTTIGLVLVLIPVVM
TAVVGWHWFDVATYQANWNTSSTTDSHAVIKSILLCLWAFVGVESAAVSTGMVKNPKRTVPLATMLGTAMAGIVYIAATQ
VIAGMYPASQMAASGAPFAISASTILGGWAAPMVSAFTAFACLTSLGSWMMLVGQAGVRAANDGNFPKVYGEVDNNGIPK
KGLLLAAVKMTALMVLITLMNSAGGKASDLFGELTGIAVLLTMLPYFYSCVDLIRFEGINIRNFVSLICSVLGCVFCFIA
LMGASSFELAGTFIVSLIILMFYGRKMHQRQNNASDNNTTANAH

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cadB NP_756989.1 lysine/cadaverine antiporter Not tested PAI II CFT073 Protein 0.0 95
cadB AAL67382.1 cadaverine/lysine antiporter Not tested PAI II CFT073 Protein 0.0 95
unnamed CAD66196.1 putative lysin/cadaverin transporter Virulence PAI III 536 Protein 2e-144 69

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
cadB YP_001334179.1 lysine/cadaverine antiporter VFG1671 Protein 1e-144 69