Gene Information

Name : KPN_04740 (KPN_04740)
Accession : YP_001338357.1
Strain : Klebsiella pneumoniae subsp. pneumoniae MGH 78578
Genome accession: NC_009648
Putative virulence/resistance : Virulence
Product : DNA-binding transcriptional activator CusR
Function : -
COG functional category : T : Signal transduction mechanisms
COG ID : COG0745
EC number : -
Position : 5193610 - 5194293 bp
Length : 684 bp
Strand : +
Note : response regulator in two-component regulatory system with CusS; regulates the copper efflux system

DNA sequence : 
GTGAAGATTTTGATTGTCGAAGATGAGAAGAAAACCGGAGAGTACCTGACCAAAGGGCTCACCGAGGCCGGCTTCGTCGT
CGACCTGGCCGATAACGGCCTCAACGGCTATCACCTGGCGATGACCAGCGATTACGATCTGCTGATCCTCGACATCATGC
TGCCGGATGTGAACGGCTGGGATATCGTGCGCATGCTGCGCGCCGCCGGGAAAGGCATGCCGATCCTGCTGCTTACCGCG
TTGGGCACCATTGAGCATCGGGTGAAGGGGCTGGAGCTGGGCGCTGACGACTATCTGGTAAAACCGTTCGCCTTTGCGGA
GCTGCTGGCGCGGGTGCGTACTCTGCTGCGCCGCGGGGCGGCGGTCATCGTCGAAAGCCAGTTTCAGGCGGCCGATCTCA
GCGTCGATTTGGTCAGCCGCAAGGTGACGCGCGGCGCCACCCGCATCACCCTGACCAGTAAGGAATTCACGCTGCTGGAG
TTCTTCCTGCGTCATCAGGGCGAGGTGCTGCCGCGTTCGTTAATTGCCTCGCAGGTGTGGGATATGAACTTCGACAGCGA
CACTAACGCCATCGACGTGGCGGTGAAGCGGCTGCGCGCCAAAATTGATAACGACTTCGAGCCAAAACTCATCCAGACCG
TGCGCGGCGTCGGCTATATGCTTGAGGTGCCGGATGGCCGCTAA

Protein sequence : 
MKILIVEDEKKTGEYLTKGLTEAGFVVDLADNGLNGYHLAMTSDYDLLILDIMLPDVNGWDIVRMLRAAGKGMPILLLTA
LGTIEHRVKGLELGADDYLVKPFAFAELLARVRTLLRRGAAVIVESQFQAADLSVDLVSRKVTRGATRITLTSKEFTLLE
FFLRHQGEVLPRSLIASQVWDMNFDSDTNAIDVAVKRLRAKIDNDFEPKLIQTVRGVGYMLEVPDGR

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
copR NP_460069.2 transcriptional regulatory protein YedW Not tested SPI-5 Protein 6e-55 52
copR AAC33719.1 regulatory protein CopR Not tested SPI-5 Protein 7e-55 52

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
KPN_04740 YP_001338357.1 DNA-binding transcriptional activator CusR BAC0111 Protein 3e-100 95
KPN_04740 YP_001338357.1 DNA-binding transcriptional activator CusR BAC0347 Protein 1e-87 83
KPN_04740 YP_001338357.1 DNA-binding transcriptional activator CusR BAC0083 Protein 6e-71 63
KPN_04740 YP_001338357.1 DNA-binding transcriptional activator CusR BAC0638 Protein 1e-63 62
KPN_04740 YP_001338357.1 DNA-binding transcriptional activator CusR BAC0308 Protein 2e-63 59
KPN_04740 YP_001338357.1 DNA-binding transcriptional activator CusR BAC0197 Protein 7e-63 59
KPN_04740 YP_001338357.1 DNA-binding transcriptional activator CusR BAC0125 Protein 6e-65 56
KPN_04740 YP_001338357.1 DNA-binding transcriptional activator CusR AE000516.2.gene3505. Protein 5e-27 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
KPN_04740 YP_001338357.1 DNA-binding transcriptional activator CusR VFG0596 Protein 2e-55 52
KPN_04740 YP_001338357.1 DNA-binding transcriptional activator CusR VFG1390 Protein 3e-45 46