Gene Information

Name : alr (KPN_04440)
Accession : YP_001338062.1
Strain : Klebsiella pneumoniae subsp. pneumoniae MGH 78578
Genome accession: NC_009648
Putative virulence/resistance : Unknown
Product : alanine racemase
Function : -
COG functional category : M : Cell wall/membrane/envelope biogenesis
COG ID : COG0787
EC number : -
Position : 4857186 - 4858265 bp
Length : 1080 bp
Strand : +
Note : converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer

DNA sequence :
ATGCAAGCGGCAACTGTAGTTATCAACCGCCGCGCTCTGCGACACAACCTGCAACGTCTGCGTGAACTGGCGCCCGCCAG
CAAACTGGTTGCGGTAGTGAAAGCGAACGCCTACGGACACGGTCTTCTCGAGACCGCGCGAACGCTGACCGACGCCGACG
CCTTTGGCGTCGCCCGCCTGGAAGAGGCGCTGCGCCTGCGAGCGGGGGGCATCGCCCAGCCGATCCTCCTGCTGGAAGGC
TTTTTTGCTGCGGAAGACCTGGCGGTGATCGCCGCCCAGCGCCTGCATACGGCGGTGCATAGCCCCGAACAGCTGGCGGC
GCTGGAGCAAGCCGATCTCCCCGAGCCGGTGACCGTGTGGATGAAGCTGGATACCGGCATGCATCGCTTAGGAGTGCGCC
CGGAGGAAGCCGAGGCGTTTTATCAGCGTCTGAGCCAGTGTAAAAACGTCCGCCAGCCGGTGAACGTGGTGAGCCACTTC
GCGCGCGCCGATGAGCCGACCTGCGGCGCCACCGAACGCCAGCTGGACATCTTCACCACCTTTACCGAAGGCAAGCCGGG
CTTGCGCTCTATCGCCGCCTCGGGCGGCATTCTGCTGTGGCCGCAATCGCATTACGACTGGGTGCGCCCCGGAATTATCC
TGTATGGCGTGTCGCCGCTGGACGATCGCTCCACCGGCAGAGATTTCGGCTGCCAGCCGGTGATGACTCTATCGTCCAGC
CTGATTGCGGTGCGCGAGCATAAAGCAGGGGAGCCCGTCGGCTACGGCGGCACCTGGATCAGCGAACGCGATACCCGTCT
CGGCGTGGTGGCGATGGGCTATGGCGACGGTTATCCGCGCGCGGCGCCGTCGGGCACGCCGGTACTGGTCAATGGCCGGG
AAGTGCCGATTGTCGGCCGGGTGGCGATGGATATGATCTGCGTTGACCTCGGACCGCAGGCCCAGGATAAAGCCGGCGAC
GCGGTAGTGCTGTGGGGAGAGGGGCTCCCGGTAGAGCGCATCGCCGAGATAACGAAAGTGAGTGCTTACGAACTTATTAC
GCGACTGACCTCCCGCGTCGCCATGAAATACTTCGACTAA

Protein sequence :
MQAATVVINRRALRHNLQRLRELAPASKLVAVVKANAYGHGLLETARTLTDADAFGVARLEEALRLRAGGIAQPILLLEG
FFAAEDLAVIAAQRLHTAVHSPEQLAALEQADLPEPVTVWMKLDTGMHRLGVRPEEAEAFYQRLSQCKNVRQPVNVVSHF
ARADEPTCGATERQLDIFTTFTEGKPGLRSIAASGGILLWPQSHYDWVRPGIILYGVSPLDDRSTGRDFGCQPVMTLSSS
LIAVREHKAGEPVGYGGTWISERDTRLGVVAMGYGDGYPRAAPSGTPVLVNGREVPIVGRVAMDMICVDLGPQAQDKAGD
AVVLWGEGLPVERIAEITKVSAYELITRLTSRVAMKYFD

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
dadX AAC61705.1 alanine racemase Not tested PAI I CFT073 Protein 4e-59 44