Gene Information

Name : thiC (KPN_04376)
Accession : YP_001338002.1
Strain : Klebsiella pneumoniae subsp. pneumoniae MGH 78578
Genome accession: NC_009648
Putative virulence/resistance : Unknown
Product : thiamine biosynthesis protein ThiC
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0422
EC number : -
Position : 4786306 - 4788201 bp
Length : 1896 bp
Strand : -
Note : required for the synthesis of the hydromethylpyrimidine moiety of thiamine

DNA sequence :
ATGTCTACTACCAAACTAACCCGTCGGGAACAACGCGAGCACGCGCAGCGATTCATTGATACGCTGGCGGGTACCGCTTT
TCCTAATTCACGCCGCATCTATGTTCACGGCTCACAAGCGGATATCCGCGTCCCGATGCGTGAAATTCAGCTCAGCCCAA
CTCTCGTCGGCGGCGATAAAGATAAACCCCGGTACGAAACCAACGAACCGATCCCGGTGTATGACACCTCCGGGCCGTAT
GGCGACCCGGATATTAGCATTGATGTCCGCCAGGGGCTGGCAAAGCTGCGCCAGCCGTGGATCGACGCGCGTAACGACTG
CGCGCCGCTCAGCGAACGCAGCTCGGCCTATACCAAAGCGCGGCTGGCCGACGACGGTCTCGATGAGCTGCGCTTCAGCG
GCCTGCTGACGCCCAAACGCGCCGTCGCTGGCAAATGCGTTACCCAGCTGCACTACGCCCGCCAGGGGATAGTCACCCCG
GAGATGGAGTTCATCGCCATTCGCGAAAACATGGGTCGCGAACGTATCCGCAGCGAGGTTCTGCGCCAGCAGCACGCAGG
TGAAGGCTTCGGCGCCCACCTTCCGGAAAACATCACCCCCGAGTTTGTTCGCGATGAAGTGGCCGCCGGACGCGCCATCA
TCCCCGCCAACATCAACCACCCGGAGTCTGAACCGATGATTATCGGCCGCAACTTCCTGGTGAAAGTGAATGCCAATATC
GGCAACTCGGCGGTGACCTCTTCCATCGAAGAAGAGGTCGAGAAACTGGTCTGGTCAACCCGCTGGGGCGCCGACACGGT
GATGGACCTCTCCACCGGCCGCTATATCCACGAAACCCGCGAGTGGATCCTGCGCAACAGCCCGGTGCCGATTGGTACCG
TGCCGATTTACCAGGCGCTGGAGAAGGTCAACGGCATCGCCGAGAATCTCACCTGGCAAGTCTTCCGCGATACCCTGCTG
GAACAGGCCGAGCAAGGCGTCGACTACTTCACGATTCACGCCGGCGTACTGTTGCGCTACGTCCCGATGACGGCGAAGCG
CCTGACCGGTATCGTCTCGCGCGGCGGCTCAATCATGGCTAAGTGGTGCCTGTCGCATCATCAGGAAAACTTCCTCTACC
AGCATTTCCGCGAAATCTGCGAAATCTGCGCCGCCTATGACGTGTCGCTGTCGCTGGGCGATGGCCTGCGCCCCGGCTCC
ATTCAGGATGCCAACGATGAGGCGCAGTTTTCCGAGCTGCGCACCCTCGGCGAACTGACGAAAATCGCCTGGGAATATGA
CGTGCAGGTGATGATTGAAGGCCCTGGCCACGTACCGATGCAGATGATCCGCCGCAATATGACCGAACAGCTGGAGCACT
GCCACGAAGCGCCATTCTACACCCTGGGGCCGCTCACCACTGATATCGCGCCGGGCTACGACCATTTCACCTCCGGTATC
GGCGCGGCAATGATCGGCTGGTTCGGCTGCGCCATGCTGTGCTATGTCACGCCGAAAGAGCATCTCGGCCTGCCCAACAA
AGAGGATGTCAAACAGGGGCTGATTACCTACAAAATCGCCGCCCACGCCGCCGACCTCGCGAAAGGCCACCCCGGGGCGC
AGATCCGCGACAACGCGATGTCAAAAGCGCGTTTTGAATTCCGCTGGGAAGACCAGTTCAACCTCGCGCTCGACCCGTTC
ACCGCGCGGGCCTATCACGATGAAACCCTGCCGCAGGAGTCCGGCAAAGTCGCCCACTTCTGCTCCATGTGCGGGCCGAA
ATTCTGTTCGATGAAAATCACTCAGGAGGTCCGCGACTACGCCGCGAAGCAAAGTATCGAAGCCGGCATGGCCGATATGT
CGAATAACTTCCGCGCCCGCGGCGGCGAAATCTACCTGAAACAGGAGGAAGCCTGA

Protein sequence :
MSTTKLTRREQREHAQRFIDTLAGTAFPNSRRIYVHGSQADIRVPMREIQLSPTLVGGDKDKPRYETNEPIPVYDTSGPY
GDPDISIDVRQGLAKLRQPWIDARNDCAPLSERSSAYTKARLADDGLDELRFSGLLTPKRAVAGKCVTQLHYARQGIVTP
EMEFIAIRENMGRERIRSEVLRQQHAGEGFGAHLPENITPEFVRDEVAAGRAIIPANINHPESEPMIIGRNFLVKVNANI
GNSAVTSSIEEEVEKLVWSTRWGADTVMDLSTGRYIHETREWILRNSPVPIGTVPIYQALEKVNGIAENLTWQVFRDTLL
EQAEQGVDYFTIHAGVLLRYVPMTAKRLTGIVSRGGSIMAKWCLSHHQENFLYQHFREICEICAAYDVSLSLGDGLRPGS
IQDANDEAQFSELRTLGELTKIAWEYDVQVMIEGPGHVPMQMIRRNMTEQLEHCHEAPFYTLGPLTTDIAPGYDHFTSGI
GAAMIGWFGCAMLCYVTPKEHLGLPNKEDVKQGLITYKIAAHAADLAKGHPGAQIRDNAMSKARFEFRWEDQFNLALDPF
TARAYHDETLPQESGKVAHFCSMCGPKFCSMKITQEVRDYAAKQSIEAGMADMSNNFRARGGEIYLKQEEA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00317 YP_008207782.1 Thiamine biosynthesis protein ThiC Not tested AbaR25 Protein 0.0 72
BJAB0868_00321 YP_008211647.1 Thiamine biosynthesis protein ThiC Not tested AbaR26 Protein 0.0 72
thiC YP_001598318.1 thiamine biosynthesis protein ThiC Not tested MDA Protein 0.0 71