Gene Information

Name : ureC (KPN_03467)
Accession : YP_001337093.1
Strain : Klebsiella pneumoniae subsp. pneumoniae MGH 78578
Genome accession: NC_009648
Putative virulence/resistance : Virulence
Product : urease subunit alpha
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0804
EC number : -
Position : 3791692 - 3793395 bp
Length : 1704 bp
Strand : +
Note : ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alp

DNA sequence :
ATGAGTAATATTTCACGCCAGGCCTATGCCGATATGTTCGGCCCAACCGTCGGCGACAAGGTGCGCCTGGCGGATACCGA
GCTGTGGATCGAGGTGGAGGACGATTTGACCACCTACGGGGAAGAGGTCAAATTCGGCGGCGGCAAAGTGATCCGCGACG
GCATGGGCCAGGGACAGATGCTGGCCGCCGACTGTGTCGACCTGGTGCTCACCAACGCGTTGATCGTCGATCACTGGGGG
ATCGTTAAGGCCGATATCGGCGTGAAGGACGGCCGGATCTTCGCCATCGGCAAAGCCGGCAACCCCGACATCCAGCCCAA
CGTCACCATCCCCATCGGCGCCGCGACGGAAGTGATCGCCGCCGAAGGAAAAATTGTCACCGCCGGCGGGATCGATACCC
ATATTCACTGGATCTGTCCGCAACAGGCGGAAGAGGCGCTGGTCTCCGGCGTGACCACCATGGTCGGCGGCGGCACCGGC
CCGGCCGCGGGCACCCATGCCACCACCTGCACCCCGGGCCCGTGGTATATCTCACGCATGCTGCAGGCGGCCGACAGCCT
GCCGGTCAATATCGGCCTGCTGGGCAAGGGCAACGTTTCTCAGCCGGATGCCCTGCGCGAGCAGGTGGCGGCGGGCGTTA
TTGGCCTGAAGATCCATGAGGACTGGGGCGCCACCCCGGCGGCGATCGACTGTGCGTTAACCGTCGCCGATGAAATGGAC
ATCCAGGTCGCCCTGCACAGCGACACCCTGAATGAATCCGGATTTGTGGAAGACACCCTCGCCGCCATCGGCGGGCGCAC
CATCCACACCTTCCATACCGAAGGAGCCGGCGGCGGCCATGCGCCGGACATCATCACCGCCTGCGCCCACCCGAACATTT
TGCCGTCGTCCACCAATCCAACGCTGCCCTACACCCTCAACACCATCGATGAACATCTCGATATGCTGATGGTCTGCCAC
CATCTGGACCCGGACATCGCCGAGGACGTGGCCTTTGCCGAGTCGCGCATTCGCCGGGAAACCATCGCTGCGGAAGACGT
GCTGCACGATCTCGGCGCCTTCTCGCTCACCTCCTCCGATTCGCAGGCCATGGGCCGCGTCGGAGAAGTGATTCTCCGCA
CCTGGCAGGTGGCGCATCGCATGAAGGTGCAGCGCGGAGCGCTGGCGGAGGAGACCGGGGATAACGACAACTTCCGCGTG
AAGCGCTACATCGCCAAATACACCATCAACCCGGCGCTGACCCACGGCATCGCACACGAAGTCGGATCCATTGAGGTGGG
TAAGCTGGCTGACCTCGTGGTCTGGTCACCAGCCTTCTTCGGCGTGAAACCGGCCACCGTGATCAAAGGCGGCATGATCG
CCATCGCGCCGATGGGCGATATCAATGCCTCTATTCCGACCCCGCAGCCGGTGCACTACCGCCCGATGTTTGGCGCGCTG
GGCAGCGCCCGCCATCACTGCCGCCTCACCTTCCTGTCGCAGGCGGCGGCAGCCAATGGCGTTGCCGAGCGGCTGAACCT
GCGCAGCGCGATCGCCGTGGTGAAAGGCTGCCGTACGGTGCAGAAAGCCGACATGGTGCACAACAGCCTGCAGCCTAACA
TCACCGTCGACGCCCAGACCTATGAGGTGCGGGTGGATGGCGAACTTATCACCAGCGAGCCGGCAGACGTTCTGCCGATG
GCGCAACGATATTTTCTGTTTTAA

Protein sequence :
MSNISRQAYADMFGPTVGDKVRLADTELWIEVEDDLTTYGEEVKFGGGKVIRDGMGQGQMLAADCVDLVLTNALIVDHWG
IVKADIGVKDGRIFAIGKAGNPDIQPNVTIPIGAATEVIAAEGKIVTAGGIDTHIHWICPQQAEEALVSGVTTMVGGGTG
PAAGTHATTCTPGPWYISRMLQAADSLPVNIGLLGKGNVSQPDALREQVAAGVIGLKIHEDWGATPAAIDCALTVADEMD
IQVALHSDTLNESGFVEDTLAAIGGRTIHTFHTEGAGGGHAPDIITACAHPNILPSSTNPTLPYTLNTIDEHLDMLMVCH
HLDPDIAEDVAFAESRIRRETIAAEDVLHDLGAFSLTSSDSQAMGRVGEVILRTWQVAHRMKVQRGALAEETGDNDNFRV
KRYIAKYTINPALTHGIAHEVGSIEVGKLADLVVWSPAFFGVKPATVIKGGMIAIAPMGDINASIPTPQPVHYRPMFGAL
GSARHHCRLTFLSQAAAANGVAERLNLRSAIAVVKGCRTVQKADMVHNSLQPNITVDAQTYEVRVDGELITSEPADVLPM
AQRYFLF

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
ureC NP_286680.1 urease subunit alpha Virulence TAI Protein 0.0 91
ureC NP_287088.1 urease subunit alpha Not tested TAI Protein 0.0 91
ureC YP_005684266.1 Urease alpha subunit Not tested PiCp 7 Protein 3e-166 64
ureC YP_005682174.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-166 64
ureC YP_003784325.1 urease subunit alpha Not tested PiCp 7 Protein 2e-166 64
ureC YP_005686358.1 Urease alpha subunit Not tested PiCp 7 Protein 2e-166 64

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
ureC YP_001337093.1 urease subunit alpha VFG0270 Protein 1e-153 62