Gene Information

Name : nrdE (KPN_03006)
Accession : YP_001336642.1
Strain : Klebsiella pneumoniae subsp. pneumoniae MGH 78578
Genome accession: NC_009648
Putative virulence/resistance : Unknown
Product : ribonucleotide-diphosphate reductase subunit alpha
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0209
EC number : -
Position : 3303425 - 3305506 bp
Length : 2082 bp
Strand : +
Note : Catalyzes the rate-limiting step in dNTP synthesis

DNA sequence :
ATGCTGAATTTGTACGACAGCGAGGGCCGCATCCCGTTTGAGAAAGATCGCCAGGCGGTTGAGGCCTTTATGGCGACCCA
GGTTCAGCCCAACGCCCTCACCTTCCCCAGCCAGGAGGATAAGCTCAGCTGGCTCGTCAGCGAGGGCTATTACGATCCGC
AGGTGCTGGCCGGCTATGACCGCGGGTTTGTGCTGGCGTTGTTCGCCCATGCCCGGCGCGCTCCGTTTCGCTTTCAGACC
TTCCTCGGCGCCTGGAAGTTCTATACCAGCTATGCGCTGAAGACCTTTGACGGCAAGCACTACCTCGAGGATTTCGCCGA
ACGCAGCGTGATGGTGGCCCTGACGCTGGCCCGGGGCGATGAACAGCAGGCGCGGCAGCTGACGGAGGAGATACTCAGCG
GCCGCTTTCAGCCCGCCACACCGACCTTCCTTAACGCTGGCAAACAGCAGCGCGGGGAGCTGATCTCCTGCTTCCTGCTG
CGTATTGAGGATAATATGGAGTCCATCGGCCGGGCGGTGAACTCGGCGCTACAGCTGTCGAAGCGCGGCGGCGGGGTGGC
CTTTTTACTCTCCAACCTGCGCGAGGCCGGGGCGCCGATCAAGCGCATCGAAAACCAGTCTTCTGGGGTGGTGCCGGTGA
TGAAGATGCTGGAGGACGCCTTCTCCTACGCCAATCAGCTCGGCGCCCGCCAGGGGGCGGGTGCGGTCTGGCTGCATGTT
CACCATCCCGATATTTTACGCTTTCTTGATACTCGGCGTGAAAATGCCGATGAGAAAATCCGCATCAAAACCTTGTCGCT
GGGGGTGGTGATCCCTGATATCACCTTCCAGCTGGCGAAAGAAGATGCGCAGATGGCCCTGTTCTCGCCTTATGACGTCG
AACGGCTGTACGGCAAACCTTTCGCCGATTGCGCCATCGGCGACCTCTATCCGCAGCTGGTGGCCGACGAGCGGGTCCGC
AAGCGCTGGATCCGCGCCCGCGACCTGTTCCAGCGCCTGGCGGAGATCCAGTTTGAATCCGGCTACCCGTACATCATGTT
TGAAGACACCGTGAACCGCGCCAGTCCGGTGGCCGGGCGGGTCACCATGAGCAATCTGTGTTCGGAGATCCTGCAGGTCA
GTACGCCGTCCGCCTATAATGAAGACCTCAGCTATGCCCATATCGGGGAAGATATCTCCTGCAACCTCGGCTCGCTGAAC
ATCGCCCACACCATGGACTCGCCGGATTTCGGCCGCACAATCGCCACCGCGGTGCGCGCCCTGACCGCCGTGTCCGACAT
GAGCCACATTCAGTCGGTTCCCTCGGTGGCGGCCGGCAACGCGGCCTCCCACGCCATCGGCCTGGGGCAGATGAATCTGC
ACGGTTACCTGGCGCGGGAGGGCATTGCCTACGGCAGCCCGGAGGGGCTGGACTTCACCAATATCTACTTCTACACCGTG
ACCTGGCACGCGCTGCACACCTCGATGCAGCTGGCCCGCGAGCGCGGCCAGCGCTTCGCCGGCTTCGAGCAGTCGCGCTA
CGCCAGCGGGGCGTACTTCGACAAATATCTGCAGGAGGAGTGGCAGCCGAAAACCGAACGGGTGCGCACGCTGTTCGCCC
GCGCCGGCATCTCTCTGCCCGACCGGGAAAGCTGGCGCCAGCTGCGCGACGATGTCATGCGCTATGGCATCTACAATCGC
TATCTGCAGGCGGTGCCGCCCACCGGCTCGATCTCGTACATCAACCATGCCACCTCCAGCATTCACCCGATCGTCTCGAA
GATTGAGATCCGCAAAGAGGGGAAAACCGGGCGGGTGTACTACCCCGCGCCATTTATGAATAACGACAATCTGGCCCTCT
ACCAGGATGCGTATGAGATAGGGCCGGAGAAGATCATTGACACTTACGCCGAGGCGACGCGCCACGTCGACCAGGGGCTG
TCGCTGACCCTGTTCTTCCCCGATACCGCCACCACCCGCGATATCAACAAGGCGCAAATTTACGCCTGGAAGAAAGGCAT
CAAGACGCTCTACTACATCCGTCTGCGCCAGCTGGCGCTGGAAGGCACTGAAATTGAAGGCTGCGTGTCCTGCGCGCTGT
AA

Protein sequence :
MLNLYDSEGRIPFEKDRQAVEAFMATQVQPNALTFPSQEDKLSWLVSEGYYDPQVLAGYDRGFVLALFAHARRAPFRFQT
FLGAWKFYTSYALKTFDGKHYLEDFAERSVMVALTLARGDEQQARQLTEEILSGRFQPATPTFLNAGKQQRGELISCFLL
RIEDNMESIGRAVNSALQLSKRGGGVAFLLSNLREAGAPIKRIENQSSGVVPVMKMLEDAFSYANQLGARQGAGAVWLHV
HHPDILRFLDTRRENADEKIRIKTLSLGVVIPDITFQLAKEDAQMALFSPYDVERLYGKPFADCAIGDLYPQLVADERVR
KRWIRARDLFQRLAEIQFESGYPYIMFEDTVNRASPVAGRVTMSNLCSEILQVSTPSAYNEDLSYAHIGEDISCNLGSLN
IAHTMDSPDFGRTIATAVRALTAVSDMSHIQSVPSVAAGNAASHAIGLGQMNLHGYLAREGIAYGSPEGLDFTNIYFYTV
TWHALHTSMQLARERGQRFAGFEQSRYASGAYFDKYLQEEWQPKTERVRTLFARAGISLPDRESWRQLRDDVMRYGIYNR
YLQAVPPTGSISYINHATSSIHPIVSKIEIRKEGKTGRVYYPAPFMNNDNLALYQDAYEIGPEKIIDTYAEATRHVDQGL
SLTLFFPDTATTRDINKAQIYAWKKGIKTLYYIRLRQLALEGTEIEGCVSCAL

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cur_1481 YP_001800875.1 ribonucleotide-diphosphate reductase subunit alpha Not tested Not named Protein 0.0 70