Gene Information

Name : topB (KPN_01208)
Accession : YP_001334871.1
Strain : Klebsiella pneumoniae subsp. pneumoniae MGH 78578
Genome accession: NC_009648
Putative virulence/resistance : Unknown
Product : DNA topoisomerase III
Function : -
COG functional category : L : Replication, recombination and repair
COG ID : COG0550
EC number : -
Position : 1358244 - 1360190 bp
Length : 1947 bp
Strand : +
Note : decatenates replicating daughter chromosomes

DNA sequence :
ATGCGGTTGTTTATTGCAGAAAAACCGAGTCTCGGTCGGGCTATCGCCGATGTGTTGCCTAAACCGCACCGCAAAGGCGA
TGGCTATATTGAGTGCGGCAACGGGCAGGTGGTCACCTGGTGTATCGGCCACCTGCTGGAGCAGGCGCAGCCGGACATCT
ACGACAGCCGCTATGCCCGGTGGAATCTCAACGATCTGCCGATTGTGCCGGAGAAATGGCAGCTGCAGCCAAAGCCCTCG
GTCACCAAACAGCTGAATGTCATCAAGCGCCTGCTCGGCGACGCCGAGGAGGTTATCCACGCCGGCGACCCGGACAGAGA
AGGGCAGCTGCTGGTGGACGAAGTACTCGACTACCTGCAGCTGGCGCCGGAGAAGCGTCAGCAGGTGCAGCGCTGTCTGA
TTAACGATCTCAACCCGCAGGCGGTGGAGCGGGCGATCAACCGTCTGCGCGCCAACAGCGAGTTCGTGCCGCTCTGCGTG
TCGGCGCTGGCGCGGGCCCGCGCCGACTGGCTGTACGGCATCAATATGACCCGCGCCTACACCCTGCTGGGGCGCAACGC
CGGCTATCAGGGGGTGCTCTCGGTGGGGCGGGTGCAGACCCCGGTACTTGGCCTGGTGGTCCGTCGCGATGAAGAGATTG
AAAATTTCGTCGCCAAAGATTTCTTCGACGTGAAGGCGCATATCGTCACGCCGCAGGAGGAGCGTTTTGTCGCCACCTGG
GTGCCGAGCGAAGCCTGCGAACCTTACCAGGATGAAGAAGGGCGCCTGCTGCATCGTCCGCTGGCCGAGCATGTGGTTAA
GCGCATCGAAGGCCAGCCGGCAATCGTGACCGGCTATAACGATAAGCGCGATTCCGAACCCGCGCCGCTGCCGTTCTCGC
TGTCGGCGCTGCAGATTGAGGCGGCCAAACGTTTCGGCTTCAGCGCGCAGAACGTGCTGGATATCTGCCAGAAGCTGTAC
GAAACCCACAAACTCATCACCTATCCGCGTTCGGACAGCCGCTATCTGCCGGAAGAGCACTTCGCTGGCCGCCATGCGGT
GTTGAATGCGATTGCCGTCCATGCGGCGGACCTGCTGCCGCAGCCGGTAGTGGATCCGGAGATCCGCAACCGCTGCTGGG
ATGATAAAAAGGTCGACGCGCACCATGCGATTATCCCAACCGCCCGCAGCAGCCAGGTGAAGCTCACCGATAACGAAGCG
AAGGTGTACACCCTGATCGCCCGCCAGTATCTGATGCAGTTCTGCCCTGACGCAGTGTTCCGCAAATGCCAGATTGATCT
TGAGATCGCCAACGGCAAGTTTGTCGCCAAGGCGCGTTTTCTGGCCGAGGCGGGCTGGCGGACGCTGCTTGGCAGCAAAG
AGCGCGATGAAGAGAACGACGGCACGCCGCTGCCGGTGGTGGCCAAAGGCGATGAACTGCTGTGCGAGAGGGGTGAGGTG
GTGGAGCGTCAGACCCAGCCGCCGCGCCACTTTACCGACGCCACGCTGCTGTCGGCGATGACCGGGATTGCCCGCTTCGT
GCAGGATAAAGATCTGAAGAAGATCCTCCGCGCCACCGACGGCCTCGGCACGGAAGCGACCCGCGCAGGGATTATCGAGC
TGCTCTTCAAGCGTGGTTTCCTGAGCAAAAAGGGGCGCTATATCCACTCTTCGGAGGCCGGCAGGGCGCTCATTCATTCC
CTGCCGGAGATGGCCGGGCGACCGGACATGACCGCCCACTGGGAGTCGGTGTTGACGCAGATCAGCGAGAAACAGTGCCG
CTATCAGGACTTTATGCAGCCGCTGGTGGGGACGCTGTATCAACTGATCGATCAGGCGCGCAGCACGCCGGTGCGTCAGT
TCCGCGGCCTGGTGGCGCCGGGCGGGGCGAAGAAGTCGTTCAGCAAAGGTAAAGGGAAGCCGAAAGGCAAAAAAGCGGCA
GACGATACCGCGCCGCCGCCGCAGTAA

Protein sequence :
MRLFIAEKPSLGRAIADVLPKPHRKGDGYIECGNGQVVTWCIGHLLEQAQPDIYDSRYARWNLNDLPIVPEKWQLQPKPS
VTKQLNVIKRLLGDAEEVIHAGDPDREGQLLVDEVLDYLQLAPEKRQQVQRCLINDLNPQAVERAINRLRANSEFVPLCV
SALARARADWLYGINMTRAYTLLGRNAGYQGVLSVGRVQTPVLGLVVRRDEEIENFVAKDFFDVKAHIVTPQEERFVATW
VPSEACEPYQDEEGRLLHRPLAEHVVKRIEGQPAIVTGYNDKRDSEPAPLPFSLSALQIEAAKRFGFSAQNVLDICQKLY
ETHKLITYPRSDSRYLPEEHFAGRHAVLNAIAVHAADLLPQPVVDPEIRNRCWDDKKVDAHHAIIPTARSSQVKLTDNEA
KVYTLIARQYLMQFCPDAVFRKCQIDLEIANGKFVAKARFLAEAGWRTLLGSKERDEENDGTPLPVVAKGDELLCERGEV
VERQTQPPRHFTDATLLSAMTGIARFVQDKDLKKILRATDGLGTEATRAGIIELLFKRGFLSKKGRYIHSSEAGRALIHS
LPEMAGRPDMTAHWESVLTQISEKQCRYQDFMQPLVGTLYQLIDQARSTPVRQFRGLVAPGGAKKSFSKGKGKPKGKKAA
DDTAPPPQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
topB AAN62317.1 putative DNA topoisomerase III Not tested PAGI-3(SG) Protein 1e-105 41
pph56 CAI36097.1 Topoisomerase IA Not tested PPHGI-1 Protein 4e-103 41
topB1 YP_005176228.1 DNA topoisomerase III Not tested ICEPmu1 Protein 4e-110 41