Gene Information

Name : guaA (Amet_0910)
Accession : YP_001318790.1
Strain : Alkaliphilus metalliredigens QYMF
Genome accession: NC_009633
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 946012 - 947544 bp
Length : 1533 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGAAGCAAGAGTTAGTATTGATATTAGATTTTGGTGGACAATATAACCAGTTAATTGCAAGAAGAGTAAGAGAGCATAA
TATTTATTGTGAAGTGGTACCTTACAAAATTACTGCAGAAGAAATTAAACTTAAAAATCCAAAGGGATTGATTTTAACCG
GAGGACCCTCCAGTGTATATGGTGAAAGTACACCTCGATGTGAGGAGGAAATTTTTCAATTGGACATACCCATATTAGGA
ATCTGTTATGGTGGACAATTAATGGCCCATACATTAGGCGGTAAGGTCAATCGTGCTAAAAACAGAGAATATGGGAAGAC
CGCTTTACAAGTAGATGGCAACTCTAAGTTATTTAAGGAAGTGGCACAGGACTCAATTTGTTGGATGAGCCATACGGATT
TTATTGAAACGGCACCAGCTGGATTTAAGATTACAGGAACCACTGCAGACTGTCCGGTGGCGGCAATGGAGAACCAAGAA
AAAGCACTTTATGCAGTACAGTTTCACCCTGAAGTAGAGCATACTGAAAAAGGCAAAGAGATATTAAAAAACTTTTTATA
TGAAGTGTGTCATTGTCAAGGAGACTGGACAATGGAAAATTATATTGAAAAGGAAATAGAAGCCATTCGAAATCTAGTGG
GAGACCGCAAGGTCCTCTGTGCTTTATCCGGTGGTGTAGATTCTTCTGTGGCTGCAGTGCTTGTTCATCAAGCAATCGGC
GACAACCTAACCTGTGTGTTTGTTGACCATGGGTTACTTCGAAAAGATGAGGGGGACTGGGTGGAAGATATCTTTAGAAA
CCAGTTCGAGATGAATTTTATTCGTGTGAATGCAGAGGAACGTTTTTTAGGAAAATTGAAGGGTGTGACGGATCCAGAGC
TGAAGCGAAAAGCGATTGGCGAGCTGTTTATCCGGGTTTTTGAAGAGGAAGCACAGAAAATTGGGGACTTTGATTTCTTA
GTCCAAGGAACCCTATATCCAGACATCATTGAAAGTGGTACTGAGACTGCGGCGGTGATTAAAAGTCATCACAATGTAGG
TGGCTTACCTGAGGATATGAAGTTTCAACTTATTGAGCCTTTTAAGTTTCTTTTTAAGGATGAAGTGAGAATCGCAGGTC
TAGAACTGGGTGTCCCTGAGGAAATTGTATGGAGACAGCCATTCCCAGGACCAGGCCTAGCTGTGCGGGTGTTAGGAGAA
ATTACAGAGGAGAAGCTCCACATTGTTCGTGAAGCTGATGCCATTGTTAGAGATGAGATTATAAAGGCAGGGCTACATCG
ACAGATTTGGCAATACTTCGCCGTATTACCCAATATTATGAGTGTTGGGGTCATGGGAGACGAAAGAACCTATGCTCATA
CAATTGGCATTCGTGCCATTACAAGCTCAGATGCCATGACCGCTGATTGGGCTCGAATCCCCTTCGAGGTTTTAGAGAAT
ATGTCTAGACGGATTGTAAATGAAGTTGAGGGTGCCAACCGTATTGTCTATGATATTACGTCTAAGCCACCATCAACAGT
GGAGTGGGAGTAG

Protein sequence :
MKQELVLILDFGGQYNQLIARRVREHNIYCEVVPYKITAEEIKLKNPKGLILTGGPSSVYGESTPRCEEEIFQLDIPILG
ICYGGQLMAHTLGGKVNRAKNREYGKTALQVDGNSKLFKEVAQDSICWMSHTDFIETAPAGFKITGTTADCPVAAMENQE
KALYAVQFHPEVEHTEKGKEILKNFLYEVCHCQGDWTMENYIEKEIEAIRNLVGDRKVLCALSGGVDSSVAAVLVHQAIG
DNLTCVFVDHGLLRKDEGDWVEDIFRNQFEMNFIRVNAEERFLGKLKGVTDPELKRKAIGELFIRVFEEEAQKIGDFDFL
VQGTLYPDIIESGTETAAVIKSHHNVGGLPEDMKFQLIEPFKFLFKDEVRIAGLELGVPEEIVWRQPFPGPGLAVRVLGE
ITEEKLHIVREADAIVRDEIIKAGLHRQIWQYFAVLPNIMSVGVMGDERTYAHTIGIRAITSSDAMTADWARIPFEVLEN
MSRRIVNEVEGANRIVYDITSKPPSTVEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 5e-162 63
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 4e-162 63
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 6e-162 63
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-137 54