Gene Information

Name : Tmel_0922 (Tmel_0922)
Accession : YP_001306168.1
Strain : Thermosipho melanesiensis BI429
Genome accession: NC_009616
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 959516 - 960928 bp
Length : 1413 bp
Strand : +
Note : TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase, barrel; Pyruvate kinase, alpha/beta

DNA sequence :
ATGAGAAAAACGCGAATAGTATCCACAATAGGGCCAGCTACTGAATCTGAGGAAATGCTTGAAAAACTTATTAAAGCAGG
AGTTAATGTATTTAGATTAAATTCTTCTCATGATGATTTAGAAACACACAGAATTAGAATTAAAAGGTTAAAGAAACTTA
GGGAAAAATTAAATGCGGTTTTTGCAATATTAATTGATTTGTCAGGACCAAAGATTAGGACGGGAAAATTGAAAAAGGAA
TATATTACATTAAAAGAAGATAGTATCATTGAAATTACAACGGAAGATGTACTAGGAGATGAAAAAGTCCTATCTGTAAA
TTACATGAGATTTCCATTTGAAGTAAAAAAAGGGGATAAAGTTTTGATTAATGATGGTGCAATTGAACTGGAGGTTTTGG
GAACAAAAGATAATATAGTAGAGGCCAAAGTAGTTAGAGGGGGTAAAATAACTCACCATAGAGGTGTTAACCTTCCAGGT
GTTGATTTATCAATATCTGCAATAACTGAAAAAGATAAGGAATTCATAAGACTTGCTATAGAAGAGAATATAGATTTTAT
TGCACTTTCTTTTGTTAGAAAACCAGAAGATGTTAAACTTGCAAAGTCTTTAAGTAATGGAATACCAATTATTGCAAAAA
TTGAAACAGCACAAGCTTTGGAATATTTACAAGAAATTATATTAGAATCAGATGGGGTTATGGTAGCAAGGGGAGATTTA
GGTGTCGAAATACCTCTTTCTAAGGTTCCAATTGTTCAAAAGCAGATTATTGAAATAGCAAATAGATTTGCAAAACCAGT
TATTACAGCAACTCAAATGCTTGAAAGTATGATAAAAAAACCAACACCAACAAGGGCAGAAGTATCTGATATTGCCAATG
CAATACTTGATGGGACAGATGCTATAATGCTTTCTGCGGAAACTTCCATTGGAAATTATCCAATAGAGGCGGTAAATGTA
ATGAATGAGGTTGCTCAAAATACGGAAAAGTTTATACTTGATTACGAATCTATAGAATTAGAATGGATAAGAAGCTATTA
TATTTCTGAGGATATAGAAGCGGCAATATCACATGCGGTTTACAATTTATCAAAAGATGTTGATGCCAGGCTTATAATAA
CCGCAACGGGTACTGGTAGAACGGCTATAAACGTTGCGAGATTAAGACCAAGTGTTCCAATAATGGCTGCCACTCCAAAT
GTTTCTACGCTATACAAATTAAGTCTTGTATGGGGGGTAATGCCTGTACTTATTAACCAAACTCTCTCCACGGATGAAAT
GATTAACGAAGTAATGAAAAAAGCAAAAGAATTAGATTTGGCTAAGAAAGGGAATAGAGTAATAATTACTGCGGGTATTC
CTTGGGGGAAACCAGGCACAACAAATACTTTACAAATTCAGGAAATTATTTAG

Protein sequence :
MRKTRIVSTIGPATESEEMLEKLIKAGVNVFRLNSSHDDLETHRIRIKRLKKLREKLNAVFAILIDLSGPKIRTGKLKKE
YITLKEDSIIEITTEDVLGDEKVLSVNYMRFPFEVKKGDKVLINDGAIELEVLGTKDNIVEAKVVRGGKITHHRGVNLPG
VDLSISAITEKDKEFIRLAIEENIDFIALSFVRKPEDVKLAKSLSNGIPIIAKIETAQALEYLQEIILESDGVMVARGDL
GVEIPLSKVPIVQKQIIEIANRFAKPVITATQMLESMIKKPTPTRAEVSDIANAILDGTDAIMLSAETSIGNYPIEAVNV
MNEVAQNTEKFILDYESIELEWIRSYYISEDIEAAISHAVYNLSKDVDARLIITATGTGRTAINVARLRPSVPIMAATPN
VSTLYKLSLVWGVMPVLINQTLSTDEMINEVMKKAKELDLAKKGNRVIITAGIPWGKPGTTNTLQIQEII

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 8e-69 42
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 3e-69 42
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 3e-69 42
pykF CAA68205.1 pyruvate kinase like protein Not tested SPI-2 Protein 4e-69 42

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
Tmel_0922 YP_001306168.1 pyruvate kinase VFG0479 Protein 1e-69 42