Gene Information

Name : guaA (Tmel_0718)
Accession : YP_001305967.1
Strain : Thermosipho melanesiensis BI429
Genome accession: NC_009616
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 752614 - 754155 bp
Length : 1542 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
TTGAAAACAGTGGTTGTTTTAGATTATGGTTCGCAGTATACCCAGCTTATTGTAAGAAGGGTACGTGAAAAGGGGTATTA
TGCAGAACTTTTACCTTGGGATGCAAAAGAAGAAGAGGTAAAAAGATTAAATCCAACTGCTATTATCCTATCCGGGGGAC
CTTCCAGTGTGTATGAGAAAGATGCTCCATTTGTACCAGAATATGTTTTACATTTGAATATTCCAATTTTGGGAATTTGT
TATGGACTTCAAGCACTTGTACATAAATTTGGTGGAAGAGTAGAAAAATCGCAAAAAAGAGAATTTGGTCATGCAATTTT
GGAGGTAGAAGAAGACCCACTATTTGAGGGATTACCAAAAAAATTTGATGTTTGGATGAGCCATTCTGATAGAGTAGAGA
AACTTCCTGAGGGGTTCTATGTAATAGGAAGAAGTGAAAATTCACCGTTTGCAGCAATAAGAAACAAAAATGAAACTATT
TATGGTGTTCAGTTTCATCCAGAGGTAACACACACACAATTTGGTTCAAAAATATTGGAAAATTTTGTTTCCAAAATTGC
AAAGATGGAAAAAAATTGGGAAATGAAGGATTTTGTTTCTGAAAAAATAAAAGAAATAAAGGGGATTGTAGGTAATGATA
AGGTAATATTGGGGCTTTCTGGAGGAGTTGATTCTTCGGTAGTTGCTATGCTTTTACACAAGGCTATAGGAGATAATTTA
GTCCCCGTGTTTGTTGATACAGGACTTTTAAGGTTAAACGAAGGAGAAGAGGTAAAAGAAAATTTTGAAAGATTGGGTAT
AAAGATTTTTGTTGTAGATGCAAAAAAGAGGTTTTTAGATGCTTTAAAAGACGTGGAAGATCCAGAAGAAAAGAGAAAAA
TAATAGGGCATACCTTTATTGATGTATTTTATGAAACCTCAATGCAACTTTTGGAAGAATTTGGTAATATAAAATACTTA
GCGCAAGGGACCCTCTACCCGGATATTATTGAGAGTAAGGTAAGCGAAAGAAAATCTGCTGCAAAGATAAAAACACATCA
CAATGTGGGGGGACTACCTGAAAAATTGCCGTTTAAGATAATAGAGCCATTAAGGTATTTATTCAAAGATGAAGTGCGGA
AGATAGGAGAAATATTGGAACTTCCTCAATCAATGATTAATAGACATCCATTTCCAGGGCCTGGACTTGCAGTAAGGATA
ATAGGGAAAGTTACAGAAGAAGCCATTAGTATATTACAAAAAGCTGACTATATATTTATCGAAGAACTGAAAAAGAACAA
TCTATATGATAAGGTCTGGCAAGCATTTGCGGTTTTTTTGCCGATAAAGTCAGTAGGAGTTATGGGAGATTACAGAACAT
ATGAGAACGTGATAGCTTTAAGGGCGGTTAACAGTTTTGATGGTATGACCGCTGATTGGTCAAAGTTACCACATGAATTT
TTAAATAAAGTTGCAAAAAGAATCATAAATGAAGTAAAAGGGGTTAATAGGGTTGTCTATGATATCACATCAAAACCACC
TGCTACAATTGAGTGGGAATAA

Protein sequence :
MKTVVVLDYGSQYTQLIVRRVREKGYYAELLPWDAKEEEVKRLNPTAIILSGGPSSVYEKDAPFVPEYVLHLNIPILGIC
YGLQALVHKFGGRVEKSQKREFGHAILEVEEDPLFEGLPKKFDVWMSHSDRVEKLPEGFYVIGRSENSPFAAIRNKNETI
YGVQFHPEVTHTQFGSKILENFVSKIAKMEKNWEMKDFVSEKIKEIKGIVGNDKVILGLSGGVDSSVVAMLLHKAIGDNL
VPVFVDTGLLRLNEGEEVKENFERLGIKIFVVDAKKRFLDALKDVEDPEEKRKIIGHTFIDVFYETSMQLLEEFGNIKYL
AQGTLYPDIIESKVSERKSAAKIKTHHNVGGLPEKLPFKIIEPLRYLFKDEVRKIGEILELPQSMINRHPFPGPGLAVRI
IGKVTEEAISILQKADYIFIEELKKNNLYDKVWQAFAVFLPIKSVGVMGDYRTYENVIALRAVNSFDGMTADWSKLPHEF
LNKVAKRIINEVKGVNRVVYDITSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-130 52
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 8e-131 52
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 8e-131 52
guaA NP_938969.1 GMP synthase Not tested Not named Protein 2e-123 49