Gene Information

Name : leuS (Tmel_0256)
Accession : YP_001305515.1
Strain : Thermosipho melanesiensis BI429
Genome accession: NC_009616
Putative virulence/resistance : Unknown
Product : leucyl-tRNA synthetase
Function : -
COG functional category : J : Translation, ribosomal structure and biogenesis
COG ID : COG0495
EC number : -
Position : 258214 - 260685 bp
Length : 2472 bp
Strand : -
Note : leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl

DNA sequence :
ATGAAAGAATATATTCCTGGAGAAATAGAACCTAAATGGCAAAAAGTTTGGGCGGAATCTAAAGTATTTGAAACGCCTCA
GCGTTCAGACAAAAAAAAATTTTATAATTTAGTTATGTTTCCATATCCTTCAGGTACATTACATGTAGGACATGTTAAAA
ATTACGTTATTGGCGATATAGTTGCAAGGTATAAAAGGATGAAAGGATATAACGTTTTGCATCCATTTGGATATGATGCA
TTTGGTCTTCCTGCGGAGAATGCGGCTATAAAGAATAAGATCCATCCAGAGGTTTGGACGTTTAAGAATATAGATATAAT
AAGAAATCAAATAAAAAAGATAGGAATTAGTTATGACTGGTCTAGAGAAGTAATTACTTGTACTGAGGAATATTACAAAT
GGACTCAATGGATTTTTTTGAAACTTTATGAAAATGGACTTGCGTACAAAAAGAAAGCAGCGGTAAATTGGTGTCCAAGT
TGTCAAACGGTGTTGGCAAACGAACAAGTTGTAGATGGTAAATGCGAAAGATGTGGTACGGAAGTAACTATGAAACATCT
TGAACAATGGTATTTTAAAATTACTGATTATGCTGAAAAACTATTAAATGACATAGATAAGTTAAGAGGTTGGCCTGAAA
ACGTAAAAATAATGCAAAAAAATTGGATAGGAAAAAGCACAGGTGCAGAAATAGATTTTCCTGTAGATAGACTTGATATG
AAAATAAAAGTTTTTACTACAAGACCTGATACTATTTGGGGAGTAACATTCATGGCAATTGCTCCCGAGTCACCTTTAGT
AGAAATGTTGGTTACTGATGAGAGAAAAGATGAACTTTCGCAATTTTTAAAGAAGGTTTCTTTGGAAGATAGGTTTAAAA
GAACAAGTTTAGAGGCTGAAAAGGAAGGATTTTTCTTGGGAAGGTATGCCATTAACCCTGTAACAGGTGAAAAAATACCA
ATATACGTTGCAAACTACATTTTATACGAATACGGAACAGGTGCAATAATGGCAGTTCCTGCTCATGATCAGAGGGATTT
TGACTTTGCAAAAAAATATGGTATTTCTATTCGCGTAGTTATAGATAATCCAGAAGAATCAATTGATGTTGAAAAAATGG
AAAAAGCATACGAAGAAGAAGGAATAATGGTCAATTCGGGACCTTTTAATGGTATGAGAAGCACTTTGGCGCTTGAGAAA
ATAATAGAATATCTTGAGGAAAAAGGTATAGGAAAAAGAAGTGTACAATACAAACTAAGGGATTGGCTTATTTCAAGACA
AAGGTATTGGGGTGCTCCAATTCCCATTGTATATTGTGAAAAGTGTGGTATTGTTCCTGTGCCTGAAAAGGATTTACCTG
TAAAGTTACCAAAAGATGTGGAGTTTTTACCTACGGGACAATCTCCTCTTTCGTTAGATGAACAATTTTTAAATACAACA
TGTCCAAAATGTGGTGGCCCCGCAAAAAGAGAAGCAGATACAATGGATACATTTGTAGATAGTTCATGGTATTATCTAAG
GTATATAAATCCAAAACTTGAAGATAAACCATTTGATACAGAAGATATAAATTATTGGATGCCAGTTGATCAGTATATAG
GTGGTGTTGAACACGCCGTTTTACACTTGCTATATTCGAGGTTTATTACCAAAGTTTTATATGATTTAGGGTATTTAAAA
TTTGAGGAACCATTTGAAAATTTATTTACTCAAGGTATGATTTACAAAGATGGTTGGAAGATGAGTAAATCAAAAGGGAA
TGTAGTTTCACCAGATGAAATGATTGAAAAGTACGGTGCAGATACGTTAAGAACTTACATACTTTTTATGGCTCCACCTG
AAAAGGATGCAGAATGGAGTGATGCGGGAATAGAAGGGGTAAATAGATTTTTAAAGAGGCTTTGGAATAATATTTATTCT
ATTTTACCAAGGATAAAAGATGTGAAAGTAGAAAAAATAGAATTGAAAAATAAACAAGAAAAAGATTTAAGAAGAAAATT
ACATCAGTCTATTAAAAAGATTACCGAGGATATAGAAGGAGGATTCAAGTTTAACACGGCTATAGCAGGATTAATGGAAT
TAAATAATAATTTGTCTGAATATTTAAATAGTGCAAAAGATTTAAATTTACCATTACTTAGAGAACTTGTGGAGAAGTTA
ACACTTATTTTATCACCATTTGCGCCACATATGGCTGAGGAAATTTGGCATGATTTGGGGAATGATACACTTGTTGTTAA
TGAGGAATGGCCAGCTTATGATGAAAATGCCCTTAAGGTTGATGAAGTTACAGTTATTATCCAAATTAATGGAAAGGTAA
GGGGAAAAATTCAAACAAAGGTTGATGTAAGTGAAGGGGAAATAAAGAAATTGGCATTTGAAAATGCAAAAATAGCTTCT
TACGTTGATGGCAGGGAAATTGTTAAAGTAATCTATGTGAAAAATAAATTACTCAATATTGTTGTAAAGTAG

Protein sequence :
MKEYIPGEIEPKWQKVWAESKVFETPQRSDKKKFYNLVMFPYPSGTLHVGHVKNYVIGDIVARYKRMKGYNVLHPFGYDA
FGLPAENAAIKNKIHPEVWTFKNIDIIRNQIKKIGISYDWSREVITCTEEYYKWTQWIFLKLYENGLAYKKKAAVNWCPS
CQTVLANEQVVDGKCERCGTEVTMKHLEQWYFKITDYAEKLLNDIDKLRGWPENVKIMQKNWIGKSTGAEIDFPVDRLDM
KIKVFTTRPDTIWGVTFMAIAPESPLVEMLVTDERKDELSQFLKKVSLEDRFKRTSLEAEKEGFFLGRYAINPVTGEKIP
IYVANYILYEYGTGAIMAVPAHDQRDFDFAKKYGISIRVVIDNPEESIDVEKMEKAYEEEGIMVNSGPFNGMRSTLALEK
IIEYLEEKGIGKRSVQYKLRDWLISRQRYWGAPIPIVYCEKCGIVPVPEKDLPVKLPKDVEFLPTGQSPLSLDEQFLNTT
CPKCGGPAKREADTMDTFVDSSWYYLRYINPKLEDKPFDTEDINYWMPVDQYIGGVEHAVLHLLYSRFITKVLYDLGYLK
FEEPFENLFTQGMIYKDGWKMSKSKGNVVSPDEMIEKYGADTLRTYILFMAPPEKDAEWSDAGIEGVNRFLKRLWNNIYS
ILPRIKDVKVEKIELKNKQEKDLRRKLHQSIKKITEDIEGGFKFNTAIAGLMELNNNLSEYLNSAKDLNLPLLRELVEKL
TLILSPFAPHMAEEIWHDLGNDTLVVNEEWPAYDENALKVDEVTVIIQINGKVRGKIQTKVDVSEGEIKKLAFENAKIAS
YVDGREIVKVIYVKNKLLNIVVK

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
leuS YP_281511.2 leucyl-tRNA synthetase Not tested Not named Protein 6e-168 44