Gene Information

Name : Tmel_1927 (Tmel_1927)
Accession : YP_001307144.1
Strain : Thermosipho melanesiensis BI429
Genome accession: NC_009616
Putative virulence/resistance : Unknown
Product : carbamate kinase-like carbamoyl phosphate synthetase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0549
EC number : 2.7.2.2
Position : 1912468 - 1913406 bp
Length : 939 bp
Strand : -
Note : this enzyme from Pyrococcus has carbamoyl phosphate synthetase activity even though the enzyme shows sequence and structural similarity to carbamate kinase; this enzyme using carbate and ATP to synthesize carbamoyl phosphate which may be a favorable react

DNA sequence :
ATGAAGAAATTAGCAGTTGTTGCAATAGGTGGTAATGCTGTAAATAGACCTGGTGAAAAACCAACAGCGGAGAACATGTT
AAAAAATCTTTCTGAAACAGCAAAATATATAGTAAATATGATTGATGAATATGATGTAGCTATAACTCATGGTAATGGAC
CACAAGTAGGTAATTTACTGGTACAGCAGGAGATAGCTAAAGATAAAATACCACCATTTCCTATTGATGTTAATGATGCA
CAAACACAGGGCAGTTTGGGATATATGATTGCACAATCTATTAGAAATCAATTGAAAGCGATTGGAAAGGATATGGAAAT
TTCTGCAGTAGTTACGCAGATTATAGTTGATAAAAATGATCCAGCATTTCAAAATCCTACTAAGCCTGTAGGTCCTTTTT
ATACAGAAGAAGAAGCAAAGATGTTGGAAAAAGAAAAAGGATGGAAGATAGTTGAAGATGCTGGAAGAGGATGGAGAAGA
GTAGTGCCATCTCCAAAACCACTGGACATAGTTGAGAAGGATGTGATAAAATTGCTTATGAAAAATGATGTTATGGTTAT
TGCAGCCGGTGGTGGAGGTATTCCAGTAATAGTTGAGGATAACAAATTAAAAGGTGTAGAGGCAGTAATTGATAAAGATA
GAGCAAGTGCTTTACTTGCAAAGGAAGTTGATGCTGATATTTTGATAATTTTAACCGGTGTAGAAAAAGTTTATTTGAAT
TTTGGAAAAGAAGACCAAAAAGCTTTAGACAAAATTACTACAACGGAAGCGAAAAAATTTTTGCAAGAAGGCCATTTTCC
GAAAGGAAGCATGGGACCTAAAATAGAGGCTGCAATAGATTTTGTTGAATCTACAGGTAAAGAATGTCTAATTACTGATA
TGTCAGTTTTAGATAAGGCCCTGAGGGGTGAGACAGGAACAAGAATTATTAAGGGGTGA

Protein sequence :
MKKLAVVAIGGNAVNRPGEKPTAENMLKNLSETAKYIVNMIDEYDVAITHGNGPQVGNLLVQQEIAKDKIPPFPIDVNDA
QTQGSLGYMIAQSIRNQLKAIGKDMEISAVVTQIIVDKNDPAFQNPTKPVGPFYTEEEAKMLEKEKGWKIVEDAGRGWRR
VVPSPKPLDIVEKDVIKLLMKNDVMVIAAGGGGIPVIVEDNKLKGVEAVIDKDRASALLAKEVDADILIILTGVEKVYLN
FGKEDQKALDKITTTEAKKFLQEGHFPKGSMGPKIEAAIDFVESTGKECLITDMSVLDKALRGETGTRIIKG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SE0102 NP_763657.1 carbamate kinase Not tested SCCpbp4 Protein 8e-57 50
arcC1 YP_186045.1 carbamate kinase Not tested vSa¥ã Protein 9e-59 49
MW1051 NP_645868.1 carbamate kinase Not tested vSa¥ã Protein 9e-59 49
SAV1170 NP_371694.1 carbamate kinase Not tested vSa¥ã Protein 9e-59 49
SA1013 NP_374286.1 carbamate kinase Not tested vSa¥ã Protein 9e-59 49
arcC YP_493761.1 carbamate kinase Not tested vSa¥ã Protein 9e-59 49
SAKOR_01091 YP_008491279.1 Carbamate kinase Not tested vSa¥ã Protein 9e-59 49
APECO1_2636 YP_859422.2 carbamate kinase Not tested Not named Protein 3e-57 47