Gene Information

Name : thyA (BDI_3749)
Accession : YP_001305058.1
Strain : Parabacteroides distasonis ATCC 8503
Genome accession: NC_009615
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 4570173 - 4570967 bp
Length : 795 bp
Strand : -
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGAAACAATATTTAGAGCTGCTCAATAGAGTGCTTACCGAGGGAGTTAGAAAAGAAGACCGGACGGGTACGGGAACGAT
CAGCGTATTCGGTCATCAGATGCGGTTCAATCTGGAAGAGGGATTCCCGCTACTCACTACCAAGAAGCTGCATCTGAAGT
CTATCATCTACGAATTGTTATGGTTCCTGAATGGAGATACCAACGTAAAATATCTGCAAGATCATGGCGTACGCATCTGG
AACGAGTGGGCCGACGCGGATGGTAGCCTTGGGCATATATACGGTTACCAATGGCGGTCATGGCCGGATTATAAAGGAGG
ATCTATCGACCAGATCACCGAGGCCGTGGAGACGATCAAGCATAACCCGGATTCACGACGAATCATTGTAAGCGCATGGA
ACGTGGCGGACTTAGACAACATGAACCTGCCTCCTTGCCACGCTTTCTTCCAGTTTTACGTGGCGAACGGACGGTTGAGC
CTACAATTGTATCAACGTAGCGCGGATATTTTCCTTGGCGTTCCGTTCAACATTGCCTCCTATGCCTTGTTATTACAAAT
GATGGCACAAGCTACCGGCCTTAAAGCGGGAGATTTTGTTCATACGTTGGGAGACGCCCATATCTACAGCAACCATTTGG
AGCAAGTTAAGTTACAATTGACACGTGAGCCACGTGCGTTGCCCCGTATGGAGATCAACCCGGACGTAAAGAGCATCTTC
GATTTTAAGTTCGAGGATTTCAATTTGACCGGATACGACCCACATCCCCACATCAAGGGAGAAGTGGCCGTCTGA

Protein sequence :
MKQYLELLNRVLTEGVRKEDRTGTGTISVFGHQMRFNLEEGFPLLTTKKLHLKSIIYELLWFLNGDTNVKYLQDHGVRIW
NEWADADGSLGHIYGYQWRSWPDYKGGSIDQITEAVETIKHNPDSRRIIVSAWNVADLDNMNLPPCHAFFQFYVANGRLS
LQLYQRSADIFLGVPFNIASYALLLQMMAQATGLKAGDFVHTLGDAHIYSNHLEQVKLQLTREPRALPRMEINPDVKSIF
DFKFEDFNLTGYDPHPHIKGEVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_001800914.1 thymidylate synthase Not tested Not named Protein 1e-84 65