Gene Information

Name : CGSHiGG_00060 (CGSHiGG_00060)
Accession : YP_001291518.1
Strain : Haemophilus influenzae PittGG
Genome accession: NC_009567
Putative virulence/resistance : Virulence
Product : pyruvate kinase
Function : -
COG functional category : G : Carbohydrate transport and metabolism
COG ID : COG0469
EC number : 2.7.1.40
Position : 7302 - 8738 bp
Length : 1437 bp
Strand : -
Note : catalyzes the formation of phosphoenolpyruvate from pyruvate

DNA sequence :
ATGTCTAGAAGACTAAGAAGAACGAAGATTGTATGTACTATGGGCCCATCAACTGACCGTGATAACAATCTTGAAAAAAT
TATCGCAGCGGGCGCAAACGTAGTTCGTATGAACTTCTCTCACGGTACACCTGATGACCATATCGGACGTGCTGAACGTG
TACGTTCTATTGCGAAAAAATTAGGTAAAACCGTGGCAATCTTAGGTGATTTACAAGGTCCTAAAATTCGTGTTTCTACT
TTTAAAGACGGTAAAATTTTCTTAAACATTGGCGATAAATTCATTCTTGATGCAGAGTTACCAAAAGGCGAAGGCACTCA
AGAATCCGTTGGTTTAGACTATAAAACGCTTCCTCAAGATGTTGTGCCGGGCGATATTCTTTTATTAGATGATGGCCGTG
TTCAATTAAAAGTATTATCAACTGATGGTGCAAAAGTTTTCACTGAAGTTACTGTTGGTGGTCCATTATCAAATAATAAA
GGTATTAATAAATTAGGTGGCGGTTTATCTGCGGATGCCCTAACAGAAAAAGATAAAGCCGACATTATTACCGCTGCACG
TATTGGTGTTGATTTCTTAGCCGTTTCTTTCCCTCGTTCAAGTGCAGATTTAAATTATGCACGTGAACTTGCTCAACAAG
CAGGTTTAAATGCAAAAATCGTTGCTAAAGTTGAACGTGCAGAAACCGTTGCTAATGATGAAGCCATGGATGATATTATT
TTAGCATCCGATGTAATTATGGTTGCTCGTGGTGACTTAGGCGTAGAAATCGGCGATCCTGAATTAGTCGGTGTACAGAA
AAAATTAATTCGTCGTTCACGTCAATTAAATCGTGCTGTAATTACAGCGACTCAAATGATGGAATCAATGATTAGCAATC
CAATGCCAACGCGTGCTGAAGTAATGGACGTTGCAAACGCAGTATTAGATGGAACTGATGCAGTTATGCTTTCTGCAGAA
ACAGCAGCAGGTCAATATCCTTCAGAAACAGTGGCAGCAATGGCTAGCGTATGTTTAGGTGCAGAAAAAATGCCAAGCAT
TAACGTTTCTCGTCACCGTATGGATAAAGAATTTGAAACCATTGAAGAGTCTGTTGCGATGTCTGCAATGTATGCAGCAA
ACCACATGAAAGGTGTAGCGGCAATCGTCACTTTAACTAGCACAGGCCGTACTCCATTATTAATGTCACGCATTAGCTCT
GGCTTACCAATCTTTGCTTTATCTCGTAATCAAGAAACCCTAAACCTTTGTGCACTATACCGCGGTGTAACACCAATTTA
TCACGGCGAAGAAAGTCGTACAGAAGCAGGTGCAAAAGCAGCACTTCAATCATTAAAAGAAAAAGGTTATTTATCTACTG
GCGATTTAGTGCTGGTAACCCAAGGTGGTCAAGGTGCGACACAAACTAACGTATGTCGTACATTAATTGTTGAATAA

Protein sequence :
MSRRLRRTKIVCTMGPSTDRDNNLEKIIAAGANVVRMNFSHGTPDDHIGRAERVRSIAKKLGKTVAILGDLQGPKIRVST
FKDGKIFLNIGDKFILDAELPKGEGTQESVGLDYKTLPQDVVPGDILLLDDGRVQLKVLSTDGAKVFTEVTVGGPLSNNK
GINKLGGGLSADALTEKDKADIITAARIGVDFLAVSFPRSSADLNYARELAQQAGLNAKIVAKVERAETVANDEAMDDII
LASDVIMVARGDLGVEIGDPELVGVQKKLIRRSRQLNRAVITATQMMESMISNPMPTRAEVMDVANAVLDGTDAVMLSAE
TAAGQYPSETVAAMASVCLGAEKMPSINVSRHRMDKEFETIEESVAMSAMYAANHMKGVAAIVTLTSTGRTPLLMSRISS
GLPIFALSRNQETLNLCALYRGVTPIYHGEESRTEAGAKAALQSLKEKGYLSTGDLVLVTQGGQGATQTNVCRTLIVE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
pykA NP_273151.1 pyruvate kinase Not tested IHT-A Protein 8e-78 49
pykF YP_216386.1 pyruvate kinase Not tested SPI-2 Protein 3e-55 41
pykF NP_805051.1 pyruvate kinase Not tested SPI-2 Protein 3e-55 41
STY1744 NP_456147.1 pyruvate kinase Not tested SPI-2 Protein 8e-56 41

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
CGSHiGG_00060 YP_001291518.1 pyruvate kinase VFG0479 Protein 1e-55 41