Gene Information

Name : tpx (CGSHiGG_07250)
Accession : YP_001292694.1
Strain : Haemophilus influenzae PittGG
Genome accession: NC_009567
Putative virulence/resistance : Virulence
Product : thiol peroxidase
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG2077
EC number : 5.1.1.7
Position : 1343957 - 1344454 bp
Length : 498 bp
Strand : -
Note : antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein

DNA sequence : 
ATGACAGTTACATTAGCAGGAAACCCTATTGAAGTTGGCGGACATTTCCCTCAAGTAGGCGAAATAGTAGAAAACTTTAT
TTTAGTCGGTAATGATTTAACCGATGTTGCATTAAACGATTTTGCAGGTAAACGCAAGGTCCTAAATATTTTTCCAAGCA
TCGACACAGGTGTATGTGCGACTTCAGTACGTAAATTTAACCAACAAGCGGCAAAATTAAGTAACACCATAGTGCTTTGT
ATTTCAGCAGACTTGCCCTTTGCTCAAGCTCGTTTTTGTGGAGCAGAAGGAATTGAAAATGCCAAAACAGTTTCAACTTT
TCGTAACCACGCATTACACTTACAATTAGGCGTAGATATTCAAACTGGTCCGTTGGCAAGTTTAACTTCTCGTGCGGTTA
TTGTGTTAGATGAACAAAACAATGTTTTACACAGCCAGTTAGTTGAAGAAATTAAAGAAGAGCCAAACTATGAAGCTGCA
TTGGCAGTGTTAGCGTAG

Protein sequence : 
MTVTLAGNPIEVGGHFPQVGEIVENFILVGNDLTDVALNDFAGKRKVLNIFPSIDTGVCATSVRKFNQQAAKLSNTIVLC
ISADLPFAQARFCGAEGIENAKTVSTFRNHALHLQLGVDIQTGPLASLTSRAVIVLDEQNNVLHSQLVEEIKEEPNYEAA
LAVLA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tpx YP_001216305.1 thiol peroxidase Not tested VPI-1 Protein 2e-35 46
tpx NP_230472.1 thiol peroxidase Virulence VPI-1 Protein 2e-35 46
tagD AAK20751.1 toxR-activated gene D protein Virulence VPI Protein 2e-35 46
tagD AAK20781.1 toxR-activated gene D protein Virulence VPI Protein 2e-35 46

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
tpx YP_001292694.1 thiol peroxidase VFG0087 Protein 7e-36 46