Gene Information

Name : tpx (CGSHiEE_08350)
Accession : YP_001291358.1
Strain : Haemophilus influenzae PittEE
Genome accession: NC_009566
Putative virulence/resistance : Virulence
Product : thiol peroxidase
Function : -
COG functional category : O : Posttranslational modification, protein turnover, chaperones
COG ID : COG2077
EC number : 6.3.5.3
Position : 1640125 - 1640622 bp
Length : 498 bp
Strand : +
Note : antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein

DNA sequence : 
ATGACAGTTACATTAGCAGGAAACCCTATTGAAGTTGGCGGACATTTCCCTCAAGTAGGCGAAATAGTAGAAAACTTTAT
TTTAGTCGGTAATGATTTAGCCGATGTTGCATTAAACGATTTTGCAGGTAAACTCAAGGTCCTAAATATTTTTCCAAGCA
TCGACACAGGTGTGTGTGCGACTTCAGTACGTAAATTTAACCAACAAGCGGCAAAATTAAGTAACACCGTAGTGCTTTGT
ATTTCAGCAGACTTGCCCTTTGCTCAAGCTCGCTTTTGTGGAGCAGAAGGGATTGAAAATGCCAAAACAGTTTCAACTTT
TCGTAACCACGCATTACACTCACAATTAGGCGTAGATATTCAAACTGGCCCGTTGGCAGGTTTAACTTCTCGTGCGGTTA
TTGTGTTAGATGAACAAAACAATGTTTTACACAGCCAGTTAGTTGAAGAAATTAAAGAAGAGCCAAACTATGAAGCTGCA
TTGGCAGTGTTAGCGTAG

Protein sequence : 
MTVTLAGNPIEVGGHFPQVGEIVENFILVGNDLADVALNDFAGKLKVLNIFPSIDTGVCATSVRKFNQQAAKLSNTVVLC
ISADLPFAQARFCGAEGIENAKTVSTFRNHALHSQLGVDIQTGPLAGLTSRAVIVLDEQNNVLHSQLVEEIKEEPNYEAA
LAVLA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
tpx YP_001216305.1 thiol peroxidase Not tested VPI-1 Protein 1e-35 47
tpx NP_230472.1 thiol peroxidase Virulence VPI-1 Protein 1e-35 47
tagD AAK20751.1 toxR-activated gene D protein Virulence VPI Protein 1e-35 47
tagD AAK20781.1 toxR-activated gene D protein Virulence VPI Protein 1e-35 47

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
tpx YP_001291358.1 thiol peroxidase VFG0087 Protein 4e-36 47