Gene Information

Name : TBFG_12409 (TBFG_12409)
Accession : YP_001288340.1
Strain : Mycobacterium tuberculosis F11
Genome accession: NC_009565
Putative virulence/resistance : Virulence
Product : bifunctional enzyme mbtA: salicyl-AMP ligase + salicyl-S-arcp synthetase
Function : -
COG functional category : Q : Secondary metabolites biosynthesis, transport and catabolism
COG ID : COG1021
EC number : -
Position : 2689231 - 2690928 bp
Length : 1698 bp
Strand : +
Note : Mapped to H37Rv Rv2384

DNA sequence : 
ATGCCACCGAAGGCGGCAGATGGCCGCCGACCCAGTCCCGACGGCGGACTGGGTGGCTTTGTACCGTTCCCCGCGGATCG
GGCCGCGTCGTACCGGGCGGCCGGCTATTGGTCGGGGCGAACCCTGGACACCGTGCTCTCCGATGCCGCGCGGCGCTGGC
CTGACCGCCTCGCGGTGGCCGACGCCGGTGATCGTCCCGGCCACGGCGGCCTCAGTTACGCCGAACTCGACCAGCGGGCC
GACCGGGCCGCCGCGGCGCTGCACGGCCTGGGCATCACGCCAGGCGACCGGGTACTGCTCCAGCTGCCAAACGGCTGCCA
GTTCGCGGTTGCCCTGTTCGCGTTATTGCGGGCGGGAGCGATCCCAGTGATGTGCCTGCCCGGTCACCGCGCCGCCGAAT
TGGGCCACTTCGCCGCCGTCAGCGCGGCCACCGGGCTGGTGGTCGCCGATGTGGCCAGCGGGTTCGACTATCGGCCGATG
GCGCGCGAACTTGTTGCCGATCACCCCACCCTGCGCCATGTCATCGTCGATGGCGATCCGGGACCGTTCGTGTCGTGGGC
GCAGCTGTGCGCCCAGGCCGGCACCGGTTCGCCGGCACCGCCGGCCGATCCCGGATCGCCAGCGCTGCTGCTGGTCTCCG
GCGGCACCACTGGCATGCCCAAACTCATTCCACGCACCCACGACGACTACGTGTTCAACGCGACGGCCAGCGCCGCACTC
TGTCGGCTTAGCGCCGACGACGTCTATCTGGTGGTGCTGGCCGCCGGCCACAATTTCCCGCTGGCCTGCCCGGGCCTGCT
CGGCGCGATGACCGTCGGGGCCACCGCCGTGTTCGCCCCCGATCCCAGCCCGGAGGCCGCCTTCGCCGCCATCGAGCGCC
ACGGTGTCACCGTCACCGCGTTGGTTCCGGCACTGGCCAAACTGTGGGCCCAATCCTGTGAGTGGGAGCCGGTGACACCG
AAGTCACTGCGGTTGTTGCAGGTTGGCGGGTCCAAGCTAGAACCCGAGGACGCTCGCCGGGTACGCACCGCGCTCACCCC
GGGCCTGCAGCAGGTGTTCGGCATGGCGGAGGGGCTGCTGAACTTCACCCGCATCGGCGACCCACCCGAAGTGGTGGAGC
ACACCCAGGGGCGGCCACTATGCCCGGCCGACGAACTGCGCATCGTCAACGCCGATGGTGAGCCGGTGGGGCCCGGGGAG
GAAGGCGAACTCTTGGTGCGCGGGCCCTACACGCTGAACGGCTATTTTGCTGCCGAACGCGACAACGAGCGCTGCTTCGA
TCCGGACGGCTTCTACCGCAGCGGCGACCTGGTCCGCCGCCGCGACGACGGCAATCTGGTGGTCACCGGGCGCGTCAAGG
ATGTCATCTGCCGTGCGGGAGAAACCATCGCCGCCAGCGACCTCGAAGAACAGCTGCTGAGCCATCCGGCGATCTTCTCG
GCCGCGGCGGTGGGACTACCTGACCAGTATCTGGGGGAAAAAATCTGCGCTGCAGTCGTTTTCGCTGGAGCTCCGATTAC
GCTTGCGGAGTTGAACGGCTACCTTGACCGGCGTGGTGTGGCCGCGCATACGCGACCCGACCAGCTGGTCGCGATGCCGG
CGCTGCCCACAACGCCGATCGGGAAGATCGACAAACGAGCGATCGTCCGCCAGCTCGGCATCGCGACGGGTCCCGTGACG
ACCCAGCGCTGCCATTGA

Protein sequence : 
MPPKAADGRRPSPDGGLGGFVPFPADRAASYRAAGYWSGRTLDTVLSDAARRWPDRLAVADAGDRPGHGGLSYAELDQRA
DRAAAALHGLGITPGDRVLLQLPNGCQFAVALFALLRAGAIPVMCLPGHRAAELGHFAAVSAATGLVVADVASGFDYRPM
ARELVADHPTLRHVIVDGDPGPFVSWAQLCAQAGTGSPAPPADPGSPALLLVSGGTTGMPKLIPRTHDDYVFNATASAAL
CRLSADDVYLVVLAAGHNFPLACPGLLGAMTVGATAVFAPDPSPEAAFAAIERHGVTVTALVPALAKLWAQSCEWEPVTP
KSLRLLQVGGSKLEPEDARRVRTALTPGLQQVFGMAEGLLNFTRIGDPPEVVEHTQGRPLCPADELRIVNADGEPVGPGE
EGELLVRGPYTLNGYFAAERDNERCFDPDGFYRSGDLVRRRDDGNLVVTGRVKDVICRAGETIAASDLEEQLLSHPAIFS
AAAVGLPDQYLGEKICAAVVFAGAPITLAELNGYLDRRGVAAHTRPDQLVAMPALPTTPIGKIDKRAIVRQLGIATGPVT
TQRCH

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
irp5 YP_001006819.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 8e-86 45
irp5 CAA73130.1 Irp5 protein Virulence HPI Protein 6e-86 45
ybtE AAA93464.1 yersiniabactin 2,3-dihydoxybenzoate-AMP ligase Virulence HPI Protein 3e-85 44
ybtE YP_853079.1 yersiniabactin siderophore biosynthetic protein Virulence PAI IV APEC-O1 Protein 5e-85 44
irp5 YP_002346898.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 4e-85 44
ybtE NP_669710.1 salicyl-AMP ligase Virulence HPI Protein 4e-85 44
ybtE NP_993003.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 4e-85 44
ybtE YP_070120.1 yersiniabactin siderophore biosynthetic protein Virulence HPI Protein 4e-85 44
ybtE CAA21394.1 - Virulence HPI Protein 4e-85 44

• Homologs from VFDB (virulence genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
TBFG_12409 YP_001288340.1 bifunctional enzyme mbtA: salicyl-AMP ligase + salicyl-S-arcp synthetase VFG1817 Protein 0.0 100
TBFG_12409 YP_001288340.1 bifunctional enzyme mbtA: salicyl-AMP ligase + salicyl-S-arcp synthetase VFG0168 Protein 2e-85 46