Gene Information

Name : TBFG_11097 (TBFG_11097)
Accession : YP_001287042.1
Strain : Mycobacterium tuberculosis F11
Genome accession: NC_009565
Putative virulence/resistance : Resistance
Product : cystathionine gamma-synthase
Function : -
COG functional category : E : Amino acid transport and metabolism
COG ID : COG0626
EC number : 2.5.1.48
Position : 1207837 - 1209003 bp
Length : 1167 bp
Strand : +
Note : catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine

DNA sequence :
ATGAGCGAAGACCGCACGGGACACCAGGGAATCAGCGGACCGGCCACCCGCGCCATCCACGCTGGCTACCGCCCGGATCC
GGCGACCGGGGCGGTGAACGTGCCGATCTACGCCAGCAGCACCTTCGCCCAAGACGGCGTCGGCGGTCTGCGTGGCGGTT
TCGAATACGCACGCACCGGCAACCCCACCCGGGCCGCATTGGAGGCCTCGCTGGCGGCAGTCGAGGAGGGTGCTTTCGCG
CGGGCATTCAGTTCCGGGATGGCCGCGACCGACTGCGCCCTGCGGGCGATGTTACGGCCCGGAGACCACGTCGTCATTCC
CGATGACGCCTACGGCGGCACATTCCGGTTGATAGACAAGGTGTTCACCCGGTGGGATGTCCAGTACACGCCGGTGCGGC
TTGCCGATCTGGATGCGGTGGGTGCCGCGATTACTCCGCGCACCCGGCTGATTTGGGTGGAGACGCCCACCAATCCGCTA
CTGTCGATCGCCGATATCACGGCCATTGCCGAGCTGGGCACAGACAGATCGGCAAAAGTATTGGTGGACAATACCTTTGC
CTCACCCGCGTTGCAGCAGCCGTTGCGGCTGGGCGCCGATGTGGTGTTGCACTCGACTACCAAGTACATCGGCGGCCATT
CCGACGTGGTGGGAGGTGCGCTGGTCACCAACGACGAAGAGCTGGACGAGGAGTTCGCTTTCTTGCAGAACGGCGCCGGC
GCGGTGCCCGGACCATTCGACGCCTACCTGACCATGCGCGGCCTGAAGACCTTGGTGCTGCGGATGCAGCGGCACAGTGA
AAATGCCTGTGCGGTAGCGGAATTCCTCGCTGATCATCCGTCGGTGAGTTCTGTGTTGTATCCGGGTTTGCCCAGTCATC
CCGGGCATGAGATTGCCGCGCGACAGATGCGCGGCTTCGGCGGCATGGTTTCGGTGCGGATGCGGGCCGGTCGGCGTGCG
GCGCAGGACCTGTGTGCCAAGACCCGCGTCTTCATCCTGGCCGAGTCGCTGGGTGGGGTGGAGTCGCTGATCGAACATCC
CAGCGCCATGACCCATGCGTCGACGGCCGGTTCGCAATTGGAGGTGCCCGACGATCTGGTGCGGCTTTCGGTCGGTATCG
AAGACATTGCCGACCTGCTCGGCGATCTCGAACAGGCCCTGGGTTAA

Protein sequence :
MSEDRTGHQGISGPATRAIHAGYRPDPATGAVNVPIYASSTFAQDGVGGLRGGFEYARTGNPTRAALEASLAAVEEGAFA
RAFSSGMAATDCALRAMLRPGDHVVIPDDAYGGTFRLIDKVFTRWDVQYTPVRLADLDAVGAAITPRTRLIWVETPTNPL
LSIADITAIAELGTDRSAKVLVDNTFASPALQQPLRLGADVVLHSTTKYIGGHSDVVGGALVTNDEELDEEFAFLQNGAG
AVPGPFDAYLTMRGLKTLVLRMQRHSENACAVAEFLADHPSVSSVLYPGLPSHPGHEIAARQMRGFGGMVSVRMRAGRRA
AQDLCAKTRVFILAESLGGVESLIEHPSAMTHASTAGSQLEVPDDLVRLSVGIEDIADLLGDLEQALG

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAR0460 YP_039909.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-71 45
SAS0418 YP_042545.1 Cys/Met metabolism PLP-dependent enzyme Not tested vSa¥á Protein 2e-72 45
metB YP_281510.1 cystathionine beta-lyase Not tested Not named Protein 7e-56 43

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
TBFG_11097 YP_001287042.1 cystathionine gamma-synthase BAC0207 Protein 1e-60 43