Gene Information

Name : thiC (MRA_0429)
Accession : YP_001281711.1
Strain : Mycobacterium tuberculosis H37Ra
Genome accession: NC_009525
Putative virulence/resistance : Unknown
Product : thiamine biosynthesis protein ThiC
Function : -
COG functional category : H : Coenzyme transport and metabolism
COG ID : COG0422
EC number : -
Position : 509892 - 511535 bp
Length : 1644 bp
Strand : -
Note : required for the synthesis of the hydromethylpyrimidine moiety of thiamine

DNA sequence :
ATGACCATCACCGTTGAACCGTCGGTGACCACGGGTCCCATCGCGGGCAGCGCCAAGGCCTACCGTGAAATCGAGGCTCC
CGGCAGCGGAGCTACTCTCCAAGTCCCGTTTCGACGGGTGCACTTGTCCACCGGAGACCACTTCGACCTCTACGACACCT
CCGGGCCCTACACCGACACGGACACGGTGATCGACCTGACCGCGGGGCTGCCGCATAGGCCCGGAGTGGTTCGCGATCGG
GGCACCCAGCTGCAGCGGGCCCGCGCCGGGGAGATCACCGCCGAGATGGCGTTCATCGCCGCCCGCGAAGACATGTCCGC
CGAGCTAGTGCGCGACGAGGTCGCCCGCGGCCGCGCGGTGATCCCGGCCAACCACCACCACCCCGAGAGCGAGCCGATGA
TCATCGGCAAGGCGTTCGCGGTGAAAGTCAACGCCAACATCGGCAACTCGGCGGTGACGAGCTCGATCGCCGAGGAGGTC
GACAAGATGGTGTGGGCCACCCGCTGGGGGGCCGACACCATCATGGACCTGTCCACCGGCAAGAACATCCACGAAACCCG
CGAGTGGATCCTGCGCAATTCTCCCGTGCCGGTCGGCACCGTGCCGATCTATCAGGCGCTGGAGAAAGTCAAGGGCGATC
CGACCGAGCTGACCTGGGAGATCTACCGCGACACCGTGATCGAGCAGTGTGAGCAAGGCGTGGACTACATGACGGTGCAC
GCCGGGGTGCTGCTGCGGTATGTGCCGCTGACCGCCAAGCGGGTCACCGGCATCGTGTCCCGCGGGGGTTCGATCATGGC
CGCGTGGTGTTTGGCACATCATCGGGAGTCGTTCTTGTACACCAACTTTGAGGAGCTCTGCGATATTTTCGCCCGCTACG
ACGTCACCTTCTCACTCGGTGACGGGCTGCGACCAGGGTCGATCGCTGATGCCAACGACGCCGCGCAGTTCGCCGAGCTG
CGCACCCTGGGCGAGCTCACCAAGATCGCCAAAGCCCATGGCGCACAGGTGATGATCGAGGGGCCGGGCCATATCCCAAT
GCACAAGATCGTCGAGAATGTGCGGCTGGAAGAGGAACTGTGTGAGGAGGCCCCGTTCTACACGCTGGGTCCGCTGGCCA
CCGACATCGCGCCGGCCTACGACCACATCACCTCGGCGATCGGTGCGGCCATCATCGCCCAAGCCGGTACCGCGATGCTG
TGCTACGTCACCCCCAAGGAGCACCTCGGGTTGCCGGACCGCAAGGACGTCAAGGACGGGGTGATCGCCTACAAGATCGC
CGCGCATGCGGCCGATTTGGCCAAGGGCCATCCGCGCGCCCAGGAGCGCGACGACGCTTTGAGCACGGCGCGTTTCGAGT
TCCGCTGGAACGACCAGTTCGCACTGTCGCTGGATCCCGACACCGCACGGGAATTCCACGACGAAACCCTGCCGGCGGAG
CCGGCCAAGACCGCGCACTTCTGCTCGATGTGCGGACCGAAGTTCTGCTCCATGCGCATCACCCAGGACGTCCGTGAGTA
CGCCGCCGAACACGGGCTTGAGACCGAAGCGGACATCGAAGCCGTGCTCGCCGCCGGAATGGCCGAAAAGTCACGTGAAT
TCGCAGAGCACGGCAATCGGGTGTATCTCCCGATAACCCAGTGA

Protein sequence :
MTITVEPSVTTGPIAGSAKAYREIEAPGSGATLQVPFRRVHLSTGDHFDLYDTSGPYTDTDTVIDLTAGLPHRPGVVRDR
GTQLQRARAGEITAEMAFIAAREDMSAELVRDEVARGRAVIPANHHHPESEPMIIGKAFAVKVNANIGNSAVTSSIAEEV
DKMVWATRWGADTIMDLSTGKNIHETREWILRNSPVPVGTVPIYQALEKVKGDPTELTWEIYRDTVIEQCEQGVDYMTVH
AGVLLRYVPLTAKRVTGIVSRGGSIMAAWCLAHHRESFLYTNFEELCDIFARYDVTFSLGDGLRPGSIADANDAAQFAEL
RTLGELTKIAKAHGAQVMIEGPGHIPMHKIVENVRLEEELCEEAPFYTLGPLATDIAPAYDHITSAIGAAIIAQAGTAML
CYVTPKEHLGLPDRKDVKDGVIAYKIAAHAADLAKGHPRAQERDDALSTARFEFRWNDQFALSLDPDTAREFHDETLPAE
PAKTAHFCSMCGPKFCSMRITQDVREYAAEHGLETEADIEAVLAAGMAEKSREFAEHGNRVYLPITQ

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
BJAB07104_00317 YP_008207782.1 Thiamine biosynthesis protein ThiC Not tested AbaR25 Protein 4e-155 68
BJAB0868_00321 YP_008211647.1 Thiamine biosynthesis protein ThiC Not tested AbaR26 Protein 4e-155 68