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Name : guaA (MRA_3436) Accession : YP_001284783.1 Strain : Mycobacterium tuberculosis H37Ra Genome accession: NC_009525 Putative virulence/resistance : Unknown Product : GMP synthase Function : - COG functional category : F : Nucleotide transport and metabolism COG ID : COG0519 EC number : 6.3.5.2 Position : 3821179 - 3822756 bp Length : 1578 bp Strand : - Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway DNA sequence : GTGGTGCAGCCTGCTGACATCGACGTGCCTGAGACACCGGCTCGACCGGTGTTGGTGGTCGACTTCGGTGCCCAATATGC CCAGTTGATTGCCCGTCGGGTTCGAGAAGCACGGGTTTTCTCCGAGGTGATTCCGCACACCGCCTCGATCGAGGAGATCA GGGCCCGTCAGCCGGTGGCGCTCGTGCTTTCCGGTGGACCGGCCAGTGTCTACGCCGACGGCGCTCCGAAACTCGATCCG GCGCTACTGGACCTCGGTGTACCGGTTCTTGGCATCTGCTACGGGTTTCAGGCCATGGCGCAGGCGCTCGGGGGGATCGT CGCCCACACCGGCACTCGCGAATACGGTCGGACTGAACTGAAAGTCCTTGGTGGCAAACTGCATTCGGATCTTCCCGAGG TTCAGCCGGTATGGATGAGTCACGGTGACGCGGTCACGGCCGCGCCGGACGGATTCGACGTGGTGGCTAGCAGCGCCGGT GCCCCGGTGGCCGCCTTCGAGGCCTTCGACCGGCGCCTGGCCGGGGTGCAGTATCACCCGGAGGTGATGCACACCCCACA CGGGCAACAGGTGCTCAGCCGGTTTTTGCACGACTTCGCCGGGCTCGGCGCCCAGTGGACGCCCGCCAACATCGCCAACG CGCTGATCGAGCAGGTGCGCACCCAGATCGGCGACGGCCACGCCATCTGCGGGCTATCCGGCGGCGTGGATTCCGCGGTG GCCGCGGCCCTGGTGCAGCGGGCCATCGGCGACCGGTTGACCTGTGTCTTCGTCGACCACGGGCTGTTGCGCGCCGGTGA GCGGGCGCAGGTGCAACGCGATTTCGTGGCCGCCACCGGCGCCAACCTGGTCACCGTCGACGCGGCCGAGACCTTCCTCG AGGCGCTGTCGGGCGTGAGCGCCCCCGAGGGCAAACGCAAGATCATCGGCCGTCAGTTCATCCGCGCGTTCGAGGGCGCG GTGCGGGATGTGCTGGACGGTAAGACTGCTGAGTTCCTGGTGCAGGGCACGCTGTATCCGGATGTGGTGGAGTCCGGCGG GGGCAGCGGCACCGCGAACATCAAGAGCCACCACAATGTCGGCGGCCTGCCCGACGACCTGAAGTTCACCCTCGTTGAGC CGCTGCGGCTGCTGTTCAAAGACGAGGTGCGCGCGGTCGGGCGGGAGTTGGGTCTGCCGGAGGAGATCGTGGCGCGCCAG CCGTTTCCGGGACCGGGGTTGGGTATTCGGATCGTCGGGGAGGTCACCGCCAAGCGGTTGGATACGCTGCGGCACGCCGA TTCGATCGTGCGTGAGGAGCTGACCGCGGCGGGCCTGGACAACCAGATCTGGCAGTGTCCGGTGGTGCTGTTGGCCGATG TCCGCTCGGTGGGTGTGCAGGGTGACGGTCGCACCTATGGCCACCCGATTGTGCTGCGTCCGGTGTCGAGTGAAGACGCG ATGACCGCCGACTGGACCCGGGTGCCCTACGAGGTGCTCGAGCGCATCTCGACCCGGATCACCAACGAGGTCGCCGAGGT CAACCGCGTGGTGCTGGACATCACCAGCAAGCCGCCCGCCACCATCGAGTGGGAGTAG Protein sequence : MVQPADIDVPETPARPVLVVDFGAQYAQLIARRVREARVFSEVIPHTASIEEIRARQPVALVLSGGPASVYADGAPKLDP ALLDLGVPVLGICYGFQAMAQALGGIVAHTGTREYGRTELKVLGGKLHSDLPEVQPVWMSHGDAVTAAPDGFDVVASSAG APVAAFEAFDRRLAGVQYHPEVMHTPHGQQVLSRFLHDFAGLGAQWTPANIANALIEQVRTQIGDGHAICGLSGGVDSAV AAALVQRAIGDRLTCVFVDHGLLRAGERAQVQRDFVAATGANLVTVDAAETFLEALSGVSAPEGKRKIIGRQFIRAFEGA VRDVLDGKTAEFLVQGTLYPDVVESGGGSGTANIKSHHNVGGLPDDLKFTLVEPLRLLFKDEVRAVGRELGLPEEIVARQ PFPGPGLGIRIVGEVTAKRLDTLRHADSIVREELTAAGLDNQIWQCPVVLLADVRSVGVQGDGRTYGHPIVLRPVSSEDA MTADWTRVPYEVLERISTRITNEVAEVNRVVLDITSKPPATIEWE |
| Gene | GenBank Accn | Product | Virulance or Resistance | PAI or REI | Alignment Type | E-val | Identity |
| guaA | NP_938969.1 | GMP synthase | Not tested | Not named | Protein | 0.0 | 78 |
| SAMSHR1132_03620 | YP_005324884.1 | GMP synthase | Not tested | vSa¥á | Protein | 9e-131 | 51 |
| guaA | YP_001331415.1 | GMP synthase | Not tested | vSa¥á | Protein | 1e-130 | 51 |
| SAPIG0468 | YP_005733278.1 | GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) | Not tested | SAPI-S0385 | Protein | 1e-130 | 51 |
