Gene Information

Name : nrdE (MRA_3083)
Accession : YP_001284427.1
Strain : Mycobacterium tuberculosis H37Ra
Genome accession: NC_009525
Putative virulence/resistance : Unknown
Product : ribonucleotide-diphosphate reductase subunit alpha
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0209
EC number : 1.17.4.1
Position : 3424255 - 3426336 bp
Length : 2082 bp
Strand : -
Note : Catalyzes the rate-limiting step in dNTP synthesis

DNA sequence :
ATGCTGAACCTGTACGACGCGGACGGCAAGATCCAGTTCGACAAGGATCGGGAAGCAGCCCACCAGTACTTTTTGCAGCA
TGTCAATCAGAACACGGTCTTCTTCCATAATCAGGACGAGAAGCTCGACTACCTGATCCGCGAGAATTACTACGAGCGTG
AGGTTCTCGACCAGTACTCGCGCAACTTCGTCAAGACGCTGCTAGACCGCGCCTACGCCAAAAAGTTCCGGTTTCCGACG
TTTTTGGGTGCGTTCAAGTACTACACCTCCTACACGCTGAAAACCTTTGACGGGAAGCGCTATCTGGAGCGCTTCGAGGA
CCGCGTGGTCATGGTGGCGCTAACGTTGGCCGCCGGCGATACCGCACTTGCCGAGCTGCTGGTCGACGAGATCATCGACG
GCCGCTTCCAGCCCGCCACACCGACGTTTTTGAATTCTGGCAAGAAGCAGCGCGGGGAGCCCGTGAGCTGTTTTTTGCTT
CGCGTCGAAGACAACATGGAGTCGATCGGACGGTCGATCAACTCCGCGCTGCAGCTATCCAAGCGTGGCGGGGGAGTGGC
GTTGCTGCTGACCAACATTCGCGAGCACGGCGCGCCGATCAAGAACATCGAGAACCAGTCCTCGGGCGTCATCCCCATCA
TGAAGTTGCTGGAGGATGCGTTCTCCTACGCCAACCAGCTGGGCGCTCGTCAAGGTGCCGGCGCGGTGTACCTGCACGCC
CATCACCCCGACATCTACCGATTCCTGGACACCAAGCGTGAGAACGCCGACGAGAAGATCCGGATCAAGACGCTGAGTCT
GGGGGTGGTGATCCCCGACATCACCTTCGAGTTGGCCAAGCGCAACGATGACATGTACCTGTTCTCGCCCTACGATGTCG
AGCGGGTCTACGGTGTGCCGTTCGCTGACATCTCGGTCACCGAGAAGTACTACGAAATGGTCGATGACGCGCGCATCCGC
AAGACCAAGATCAAGGCACGGGAGTTCTTCCAGACGCTGGCCGAGCTGCAGTTCGAGTCCGGCTACCCCTATATCATGTT
CGAAGACACCGTCAATCGCGCTAATCCAATTGATGGCAAGATCACGCACAGCAACCTGTGCTCGGAGATCCTGCAAGTGT
CTACGCCGTCATTGTTCAACGAGGACTTGTCGTATGCCAAAGTGGGCAAAGACATTTCGTGCAACCTGGGGTCGCTGAAC
ATCGCCAAGACGATGGACTCGCCGGACTTCGCGCAGACGATCGAGGTGGCGATCCGCGCGTTGACCGCGGTGAGCGACCA
AACCCATATCAAGTCGGTGCCCTCAATCGAGCAGGGCAACAACGACTCCCACGCGATCGGGCTAGGACAGATGAACCTGC
ACGGCTACCTGGCCCGGGAACGCATCTTCTACGGATCCGACGAAGGCATCGACTTCACCAACATCTACTTCTATACGGTG
CTGTATCACGCGTTGCGGGCATCCAACCGCATCGCGATCGAACGCGGCACGCACTTCAAGGGTTTCGAGCGGTCCAAGTA
CGCGTCCGGGGAATTCTTCGACAAGTACACCGACCAGATTTGGGAGCCGAAGACCCAGAAGGTACGCCAGCTGTTCGCCG
ACGCCGGCATCCGCATCCCAACGCAGGACGACTGGCGTCGGCTCAAGGAGTCGGTGCAAGCGCACGGCATCTACAACCAG
AACCTGCAGGCGGTGCCGCCGACCGGGTCGATTTCCTACATCAACCATTCGACGTCGTCGATTCACCCGATCGTGTCGAA
GGTCGAGATCCGCAAGGAAGGCAAGATCGGGCGGGTCTACTACCCGGCGCCGTATATGACCAACGACAACCTGGAGTACT
ACGAAGACGCCTACGAGATCGGTTACGAGAAGATCATCGACACCTACGCGGCGGCCACCCAGCATGTGGATCAAGGGCTT
TCGCTGACGTTGTTCTTCAAAGACACCGCCACCACCCGCGACGTGAACAAGGCGCAGATTTACGCCTGGCGCAAGGGGAT
CAAGACGCTGTACTACATCCGGCTGCGGCAGATGGCGTTGGAGGGCACCGAGGTCGAGGGTTGCGTGTCCTGCATGCTGT
AG

Protein sequence :
MLNLYDADGKIQFDKDREAAHQYFLQHVNQNTVFFHNQDEKLDYLIRENYYEREVLDQYSRNFVKTLLDRAYAKKFRFPT
FLGAFKYYTSYTLKTFDGKRYLERFEDRVVMVALTLAAGDTALAELLVDEIIDGRFQPATPTFLNSGKKQRGEPVSCFLL
RVEDNMESIGRSINSALQLSKRGGGVALLLTNIREHGAPIKNIENQSSGVIPIMKLLEDAFSYANQLGARQGAGAVYLHA
HHPDIYRFLDTKRENADEKIRIKTLSLGVVIPDITFELAKRNDDMYLFSPYDVERVYGVPFADISVTEKYYEMVDDARIR
KTKIKAREFFQTLAELQFESGYPYIMFEDTVNRANPIDGKITHSNLCSEILQVSTPSLFNEDLSYAKVGKDISCNLGSLN
IAKTMDSPDFAQTIEVAIRALTAVSDQTHIKSVPSIEQGNNDSHAIGLGQMNLHGYLARERIFYGSDEGIDFTNIYFYTV
LYHALRASNRIAIERGTHFKGFERSKYASGEFFDKYTDQIWEPKTQKVRQLFADAGIRIPTQDDWRRLKESVQAHGIYNQ
NLQAVPPTGSISYINHSTSSIHPIVSKVEIRKEGKIGRVYYPAPYMTNDNLEYYEDAYEIGYEKIIDTYAAATQHVDQGL
SLTLFFKDTATTRDVNKAQIYAWRKGIKTLYYIRLRQMALEGTEVEGCVSCML

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cur_1481 YP_001800875.1 ribonucleotide-diphosphate reductase subunit alpha Not tested Not named Protein 0.0 79