Gene Information

Name : RoseRS_2450 (RoseRS_2450)
Accession : YP_001276777.1
Strain : Roseiflexus sp. RS-1
Genome accession: NC_009523
Putative virulence/resistance : Resistance
Product : heavy metal translocating P-type ATPase
Function : -
COG functional category : P : Inorganic ion transport and metabolism
COG ID : COG2217
EC number : -
Position : 3026545 - 3028761 bp
Length : 2217 bp
Strand : +
Note : TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; cadmium-translocating P-type ATPase; heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase domain protein hydrolase; Heavy metal transport/detoxification protein; E1-E2

DNA sequence :
ATGCAGACACGCAACTACATCTTCGCCATTCACGGCATCGACTGCGCGCATTGCGCGAACACCATCGAGGTGAGCGTCGC
TCGTCTCGATGGCGTCGAGGCGTGCGAACTCAACGCGACGACCGGTCGGCTCCGTGTGCGCGGCGCCGTCGAACCTGATG
CAATTATTACGTATGTGCGTTCGCTGGGGTATGAGGCGACGCTGCTGGAAAACGACGGTGTAACGCCGACGACCCCCGAC
GCATCGGTGTCGTTTGTTGAGTTCATGTGGCAACGCCTTGAAACGCGCCTGGCGCTGATCGGCGCAATAATGATCGTTCC
AGGCGTTGTCCTGCATGAACTGCTCGGATGGCGCGCCTTCTGGATCGACGCCCTGGCATTTGCTGCGCTGATTGCCGCCG
GTCTGCCGATCGCGCGCAGCGCCTGGCGTTCACTCGTCCGCAGTCGCACGATCTCGATCAATGCGCTGATGACCATTGCC
GCAATTGGGGCGGTGATCATTGGAGCGCATGTCGAAGCTGCCCTGGTTATGGTATTATTTGCCATTGGCGAGGCGATCGA
AGGGTTTACCGCTGCGCGCGCACGCGATGCCATTCGTTCGCTGATGACGCTTGTTCCTGAAACTGCTCTGCGCCTCCGCG
ACGGATATGAAACAAGGACGCCGGTCGCCGAACTGAAGGTTGGCGACGTCATCGTTGTGCGCCCTGGCGAGCGTGTGCCG
ATGGATGGCGTCGTGCGCAGCGGCGCGACGCATATCAACCAGGCGCCGATCACCGGCGAGAGTGTGCCGGTCGTCAAGAC
GCCGGGAGCGGAAGTGTATGCCGGGAGCATCAACGGCGAAGGCGTGATCGAGGTGATTGTCACGCATCTGGCAAGCGACA
ACACGATCAGTCGCATGATCCGCCTGGTGCAGGAGGCGCAGGATCGCCGTGCGCCCGTGCAGCGCCTGATTGATCGCTTT
GCAGGATGGTATACGCCGGCAGTGGTTGCCATTGCTGCGCTGATCGCCGTCATCCCGCCGCTGCTGTTCGGGCAACCGTT
CTGGAACCCGTCGCCGGACGAATTCGGCTGGTTCTACCGTAGTCTGGCGCTTCTGGTCGTCGCCTGTCCCTGCGCGCTCG
TCATCAGCACGCCGGTGAGCGTGGTCAGTGCGTTGAGCGCTGCAGCGCGCGCTGGCGTGCTGATCAAAGGCGGTGCGGCG
CTGGAGGCGCTTGGCAAGGTGCGCGCTGTCGCATTCGATAAAACCGGCACCCTGACCACGGGCAGACCGGTGCTCGTTGC
AGTACGCTCGGTGGAATGCCGCGAGCCGGAACAGAACGAGGATGCACGTTGCGACGCATGCACAACGCTGCTCGAACTTG
CCTGCGCCGTCGAGCAACGCTCCGAACATCCCCTGGCGCACGCGATTGTCGATGCCGCCCGCGTGCGGGGAGTCATGCAG
AACGCGCCACGCGCCACATCCGTCACGGCGCTGCCGGGTCACGGGATTGTGGGGGATGTGAATGGGCGCACGGTCCTCAT
CGGCAGCCATCGTTACTTCGATGAAACAGCGCCTCACCCGCTCGCCTTCTGTGATCGCGCGGAACGGGACGCTGGCGCCG
GTCGCACGCCGCTGATGGTCAGCATCGATGGGACGTTCGCCGGTATGCTGAGCGTCGCCGACGCCATTCGCCCTGAAGCC
CGCGAAGCGATTGCGCGCCTGAGACGAGCAGGGATTCAACACGCCGTCATGCTCACCGGCGACCGCCGTGAAACGGCGCA
GGCCATCGCCGCCGACGCTGGCATCGATGATGTGCGTGCTGAAGTGCTCCCCGAATACAAAGCGCAGATGGTCGAAAACC
TCCGCGCCACCTACGGCGCTGTGGCAATGGTCGGCGACGGCATCAACGATACTCCCGCCCTGGCATCGGCAACTGTCGGC
ATTGCCATCGGTGCGGCGCACGGCGGAACGAATCAGGCAATGGAAACCGCTGATGTCACTCTGATGAGCGATGACCTGCG
CCGCCTGCCATTCGTGTTCGAGCTGGCGCGCGCCACACGCCGCACAATTATGGTCAATGTCGCCTTTAGCATTGCCGTCA
AGGCGGTGTTTCTGGTGATTGTTGCAGCAGGCTGGAGTACCATGTGGATGGCGGTGTTCGCCGATATGGGGACATCGCTG
CTGGTAACGTTGAACGGTCTGCGGTTGCTGGGGATGCGCCACCAGGGAGAGGCGTGA

Protein sequence :
MQTRNYIFAIHGIDCAHCANTIEVSVARLDGVEACELNATTGRLRVRGAVEPDAIITYVRSLGYEATLLENDGVTPTTPD
ASVSFVEFMWQRLETRLALIGAIMIVPGVVLHELLGWRAFWIDALAFAALIAAGLPIARSAWRSLVRSRTISINALMTIA
AIGAVIIGAHVEAALVMVLFAIGEAIEGFTAARARDAIRSLMTLVPETALRLRDGYETRTPVAELKVGDVIVVRPGERVP
MDGVVRSGATHINQAPITGESVPVVKTPGAEVYAGSINGEGVIEVIVTHLASDNTISRMIRLVQEAQDRRAPVQRLIDRF
AGWYTPAVVAIAALIAVIPPLLFGQPFWNPSPDEFGWFYRSLALLVVACPCALVISTPVSVVSALSAAARAGVLIKGGAA
LEALGKVRAVAFDKTGTLTTGRPVLVAVRSVECREPEQNEDARCDACTTLLELACAVEQRSEHPLAHAIVDAARVRGVMQ
NAPRATSVTALPGHGIVGDVNGRTVLIGSHRYFDETAPHPLAFCDRAERDAGAGRTPLMVSIDGTFAGMLSVADAIRPEA
REAIARLRRAGIQHAVMLTGDRRETAQAIAADAGIDDVRAEVLPEYKAQMVENLRATYGAVAMVGDGINDTPALASATVG
IAIGAAHGGTNQAMETADVTLMSDDLRRLPFVFELARATRRTIMVNVAFSIAVKAVFLVIVAAGWSTMWMAVFADMGTSL
LVTLNGLRLLGMRHQGEA

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
cadA BAC57487.1 Probable cadmium-transporting ATPase (Cadmium efflux ATPase) Not tested Type-IIIinv SCCmec Protein 2e-87 41
unnamed BAB47609.1 cadmium resistance protein B Not tested Type-III SCCmec Protein 2e-87 41

• Homologs from CARD and BacMet (resistance genes)

GeneGenBank Accn Product ID of source DB Alignment Type E-val Identity
RoseRS_2450 YP_001276777.1 heavy metal translocating P-type ATPase BAC0298 Protein 2e-63 46
RoseRS_2450 YP_001276777.1 heavy metal translocating P-type ATPase BAC0092 Protein 5e-61 42