Gene Information

Name : guaA (RoseRS_2132)
Accession : YP_001276463.1
Strain : Roseiflexus sp. RS-1
Genome accession: NC_009523
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 2624717 - 2626255 bp
Length : 1539 bp
Strand : +
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGCACGAATCAATTCCTGTCCTTGACTTTGGATCGCAAACGGCGCAACTGATCGTTCGTCGGTTGCGCGAACTTGGCGT
CTACAGCGAACTTGTGCCGCACGATGCGCCAAAAGAGGACGTGCTGGCGCTGCAACCACGCGGCATCGTTCTTTCTGGCG
GTCCGGCCAGCGTCTATGAGCCGGGCGCGCCGCAACTGCCGTTATGGCTTCGCGAAAGCGATCTCCCCGTGCTTGGCGTC
TGTTATGGCATGCAGGTGCAGGCGCACGCGCTCGGCGGGCGTGTCGAGGGTATGCAGAGCCGCGAGTTCGGTCCGGCTGA
GATCACGGTGGTCGATCCCGGTCTGCTCTTCGCCGACACCCCGATGCACCAGCAGGTGTGGATGAGCCATGGGGATCACA
TCGCTGCGCTGCCCGCCGGCTTCCGCGTGATGGCGCACAGCTCTGGCGCGCCGTTTGCCGCTGCCGGCGACGATCAACGG
CGCTGGTACGGCATCCAGTTCCATCCCGAAGTGGTTCATACCCGTTTCGGGCGCGACATACTGCGCAATTTCGCATTCCG
CATCTGCGGATGTCGCGGCGACTGGCAACCGGCGAGTTTCATTGCTGAGGCGATTGCGCGAGTACGAGATCAGGTTGGTA
ATGGACGGGTGATCTGCGCCCTCTCTGGTGGGGTCGACTCGGCGGTGGCGGCATTGATCGTTCACCGGGCGATTGGTGAT
CGCCTGACCTGCGTGTTTGTCGATAACGGGCTGCTGCGCCAGGGTGAAGCCGAACAGGTTGTCGCCACATTCCGCGAGCA
TTTTCATATTCCGCTGATCGCAGTCGATGCGGCGGATGAGTTCCTCGACGCTCTTGCCGGTGTCGCCGACCCTGAGCAGA
AACGGAAGATCATCGGTGAAAAATTCGTGCGCATCTTCGAGCGCGAGGCGCGGCGCATCGAAGGCGCGCGCTTTCTGGCG
CAGGGAACGCTCTATCCCGATGTCATCGAGAGCAAGGCGCCGGATCGTCAGAAGGGCGTGACGATCAAAACTCATCACAA
CGTCGGCGGGCTGCCAGCCGATATGCAGTTGACCCTGGTCGAGCCGCTGCGTTACCTGTTCAAAGATGAAGTGCGCGCCG
CCGGTCTTGCACTGGGTTTGCCGGAAGAGTGGGTCTGGCGACATCCTTTCCCCGGTCCCGGTCTGGCGGTGCGTGTGCTT
GGTCCGGTCACGCGGGAACGCCTGGCAACCCTGCGCGCCGCCGATGCCATTTTTATGCACGAGTTGCGCACCGCCGGGCT
GTACCGCGCAACGCAACAGGCATTCGCCGTGCTGCTGCCGGTTCGCAGCGTCGGCGTGATGGGCGATGGACGCACCTATG
CCGACGTGATCGCGCTGCGCGCCGTCACAACCGAGGATTATATGACAGCAGATTGGGCGCGTCTGCCCGCCGATGTGCTG
GCGCGTGTCAGCAGTCGGATCGTGAATGAAGTCCCCGGCGTCAATCGCGTGGTCTACGACATTTCCTCCAAGCCTCCCGC
AACGATTGAATGGGAATAG

Protein sequence :
MHESIPVLDFGSQTAQLIVRRLRELGVYSELVPHDAPKEDVLALQPRGIVLSGGPASVYEPGAPQLPLWLRESDLPVLGV
CYGMQVQAHALGGRVEGMQSREFGPAEITVVDPGLLFADTPMHQQVWMSHGDHIAALPAGFRVMAHSSGAPFAAAGDDQR
RWYGIQFHPEVVHTRFGRDILRNFAFRICGCRGDWQPASFIAEAIARVRDQVGNGRVICALSGGVDSAVAALIVHRAIGD
RLTCVFVDNGLLRQGEAEQVVATFREHFHIPLIAVDAADEFLDALAGVADPEQKRKIIGEKFVRIFEREARRIEGARFLA
QGTLYPDVIESKAPDRQKGVTIKTHHNVGGLPADMQLTLVEPLRYLFKDEVRAAGLALGLPEEWVWRHPFPGPGLAVRVL
GPVTRERLATLRAADAIFMHELRTAGLYRATQQAFAVLLPVRSVGVMGDGRTYADVIALRAVTTEDYMTADWARLPADVL
ARVSSRIVNEVPGVNRVVYDISSKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA NP_938969.1 GMP synthase Not tested Not named Protein 7e-126 56
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-139 55
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-139 55
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 1e-139 55