Gene Information

Name : thyA (Lreu_0769)
Accession : YP_001271370.1
Strain : Lactobacillus reuteri DSM 20016
Genome accession: NC_009513
Putative virulence/resistance : Unknown
Product : thymidylate synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0207
EC number : 2.1.1.45
Position : 843180 - 844142 bp
Length : 963 bp
Strand : +
Note : ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived

DNA sequence :
ATGGCAACAAATGTAAATGAAGAGCAATACTTAGACTTAATCCGTTATGTTTTGGCGAATGGACATCAAAAGGGTGATCG
GACAGGAACAGGTACTAAATCTGTTTTCGGATATCAGATGCGATTTGACCTAAGCAAAGGTTTTCCTATTTTAACGACTA
AGAAAGTCCCATTTGGCTTGATTAAGAGTGAATTACTATGGTTTTTACGCGGTGATACCAACATTCGCTTCTTACTTCAA
CACAAGAATCATATTTGGGATGAATGGGCATTTAAGAAGTGGGTGGAAAGTGATGAATATCAAGGTCCAGATATGACGGA
CTTTGGTCACCGCTGGCTTAAAGATCCAGAGTTTAAGCAGGTCTATCTTCAAGAAAAGAAGGCTTTCTGTCAGCGAATTC
TTGAAGATGATGATTTTGCCCAAAAATATGGCGACTTAGGACTTGTTTATGGAAGTCAGTGGCGAAAATGGAAGACGAGT
CAAGGCGACACAATTGATCAAATTGCTAATGTTATCCAGCAGATTAAAACTACTCCGGATTCACGACGGATGATTGTTTC
GGCTTGGAATCCAGAAGATGTTCCTTCTATGGCTCTCCCTCCATGTCACACCATGTTCCAATTTTATGTTAATGATGGAA
AGCTTAGTTGTCAGCTCTATCAACGGAGTGCCGACATCTTTTTAGGGGTTCCATTCAATATCGCTAGTTATGCCTTATTG
ACGCATATGATTGCTCACCAATGCGGTTTAGAACCTGGCGAGTTTGTTCATACATTAGGGGATGCTCACATTTATCTGAA
CCATCTTGATCAAGTTAAAGAACAGCTGACAAGAACACCTCATGAAGCTCCTAAATTGATTTTACCTGCTGAACCAAAAC
CAATCGATCAATATGAAATGACTGATATTAAGTTAGAAGGCTATACTCATGAGCCGGCAATCAAGGCTCCCGTAGCAGTT
TAA

Protein sequence :
MATNVNEEQYLDLIRYVLANGHQKGDRTGTGTKSVFGYQMRFDLSKGFPILTTKKVPFGLIKSELLWFLRGDTNIRFLLQ
HKNHIWDEWAFKKWVESDEYQGPDMTDFGHRWLKDPEFKQVYLQEKKAFCQRILEDDDFAQKYGDLGLVYGSQWRKWKTS
QGDTIDQIANVIQQIKTTPDSRRMIVSAWNPEDVPSMALPPCHTMFQFYVNDGKLSCQLYQRSADIFLGVPFNIASYALL
THMIAHQCGLEPGEFVHTLGDAHIYLNHLDQVKEQLTRTPHEAPKLILPAEPKPIDQYEMTDIKLEGYTHEPAIKAPVAV

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
thyA YP_189147.1 thymidylate synthase Not tested ¥ÕSP¥â Protein 1e-97 62