Gene Information

Name : guaA (Swit_1321)
Accession : YP_001261824.1
Strain : Sphingomonas wittichii RW1
Genome accession: NC_009511
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : 6.3.5.2
Position : 1477146 - 1478738 bp
Length : 1593 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGACAGCCCAGCTTCCCGCCACCGCCCCGAAGGCCAGCCAGCCGCACGAGTCGATCCTGATCGTCGACTTCGGCAGCCA
GGTCACCCAGCTCATCGCGCGCAGGGTCCGCGAGGCCGGCGTCTACAGCGAGATCGCACCCTTCAACGCCGCCGATGCCG
CGTTCGACCGGCTCCAGCCCAAGGGAATCATCCTGTCGGGCGGCCCCGCCTCGGTCGCCGAGATGGGATCGCCCCGCGCG
CCGCAGCGCTTCTTCGAGGCGGGGGTGCCGATCCTCGGCATCTGCTACGGCCAGCAGACGATGTGCCAGCAACTCGGCGG
GTCGGTGACGCCGAGCCACGACAGCCGCGAGTTCGGCCGCGCCTTCATCGAGATCAAGACCCGCTCGGCGCTGTTCGACG
GCCTCTGGAAGGAGGGCGAGCATCATCAGGTGTGGATGAGCCATGGCGACAAGGTCGACGCGCTGCCGCCCGGCTTCTCG
CCGGTCGCAGTGTCGGAGGGCGCGCCCTATGCCGTCACCTCGGACGAGAAGCGCCGCTTCTACGGTGTGCAGTTCCACCC
GGAGGTCGTCCACACCCCCGATGGCGGCAAGCTGATCGCCAATTTCGCCCGCCATGTCTGCGGCCTGACCGGCGACTGGA
CGATGGCCGAGTTCCGCGCGACCAAGATCGAGGAGATCCGCCAGCAGGTCGGCGACGGCCGGGTGATCTGCGGCCTGTCG
GGCGGTGTCGACAGTGCGGTCGCGGCGGTGCTGATCCACGAGGCGATCGGCGACCAGCTCACCTGCGTGTTCGTCGACCA
TGGCCTGATGCGGATGGGCGAGGCCGACCAGGTCGTCGGTCTGTTCCGCGAGCATTACGGCATCCCGCTCGTCCATGTGA
ACGCCGAGACGCTGTTCCTCAACGGCCTCAAGGGCGTCACCGACCCGGAGGCCAAGCGCAAGTTCATCGGCAAGACCTTC
ATCGAGGTGTTCGAGGCCGAGGCGAAGAAGATCGGCGGCGCTGACTTCCTGGCGCAGGGCACGCTCTACCCCGACGTGAT
CGAGAGCGTCAGCTTCACCGGCGGCCCGTCGGTGACGATCAAGAGCCACCACAATGTCGGCGGCCTTCCCGAGCGGATGA
ACATGAAGCTCGTCGAGCCGCTGCGCGAGCTGTTCAAGGACGAGGTCCGCGCGCTCGGCCGCGAGCTGGGCCTGCCCGAG
ATCTTCGTCGGCCGCCACCCCTTCCCGGGGCCGGGCCTCGCGATCCGCATCCCCGGCGAGGTGACCAAGGAGCGCTGCGA
CATCCTGCGCAAGGCCGACGCCGTCTATCTCGACGAGATCCGCCGCGCGGGCCTCTACGACGCGATCTGGCAGGCCTTCG
CGGTGCTGCTGCCGGTCCGCTCGGTCGGCGTGATGGGTGACGGCCGCACCTATGACTCGGTCTGCGCCCTGCGCGCCGTC
ACCTCGACCGACGGCATGACCGCCGACGTCTACCCGTTCGACGCCGCCTTCCTGAGCCGCGTCGCGACCCGTATCGTCAA
CGAGGTGCAGGGCATCAACCGGGTGACCTACGACTACACCTCCAAGCCGCCCGGGACGATCGAGTGGGAGTAA

Protein sequence :
MTAQLPATAPKASQPHESILIVDFGSQVTQLIARRVREAGVYSEIAPFNAADAAFDRLQPKGIILSGGPASVAEMGSPRA
PQRFFEAGVPILGICYGQQTMCQQLGGSVTPSHDSREFGRAFIEIKTRSALFDGLWKEGEHHQVWMSHGDKVDALPPGFS
PVAVSEGAPYAVTSDEKRRFYGVQFHPEVVHTPDGGKLIANFARHVCGLTGDWTMAEFRATKIEEIRQQVGDGRVICGLS
GGVDSAVAAVLIHEAIGDQLTCVFVDHGLMRMGEADQVVGLFREHYGIPLVHVNAETLFLNGLKGVTDPEAKRKFIGKTF
IEVFEAEAKKIGGADFLAQGTLYPDVIESVSFTGGPSVTIKSHHNVGGLPERMNMKLVEPLRELFKDEVRALGRELGLPE
IFVGRHPFPGPGLAIRIPGEVTKERCDILRKADAVYLDEIRRAGLYDAIWQAFAVLLPVRSVGVMGDGRTYDSVCALRAV
TSTDGMTADVYPFDAAFLSRVATRIVNEVQGINRVTYDYTSKPPGTIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 4e-134 55
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 4e-134 55
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 3e-134 55
guaA NP_938969.1 GMP synthase Not tested Not named Protein 1e-119 53