Gene Information

Name : guaA (LPC_1156)
Accession : YP_001250468.1
Strain : Legionella pneumophila Corby
Genome accession: NC_009494
Putative virulence/resistance : Unknown
Product : GMP synthase
Function : -
COG functional category : F : Nucleotide transport and metabolism
COG ID : COG0519
EC number : -
Position : 1994762 - 1996339 bp
Length : 1578 bp
Strand : -
Note : contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway

DNA sequence :
ATGAATGATTTGAAAAAAAGCCCATTATTAATATTAGATTTTGGTTCTCAATACACCCAATTAATTGCAAGACGCGTTCG
AGAAATGGGGGTTTATTGTGAAATTTATCCTTATCATATTAATCATGAACAATTTAAAAAATTAAATCCTTGTGGTGTGA
TTTTATCAGGAGGTCCTTCCACAGTAACGCATGATGCTAATCCCAGAGCTCCTCAATGGCTGTTTGAGAGCGATTTACCA
TTGCTGGGTATATGCTATGGGATGCAAACCATGGCTGTACAACTCGGTGGCCAAGTGCATTCATCGGCGTTAAGAGAATT
TGGATATGCTGAGTTGCGTTTGCATGGCCATAGTCAATTATTAAGTAATATCGAAGATCGTACCGCGGTGGATGGCAGTG
CTCTACTGGATGTATGGATGAGCCATGGTGATAAAGTCACTGAGTTACCGCCAGGTTTTAAAGTGATATGTGAAACACGT
AATGCACCAATTGCAGGTATGGCTGATGAAAGTCGTCAAATGTATGGTTTGCAATTTCATCCAGAAGTTACTCATACCTT
GCAAGGTTTAAGAATTTTACAACGTTTTGTCGTAGATATTTGTAAAGCACCAACAGAGTGGACTCCAGAGCATATTATTG
ATGAAGCCATTAATAAAATCAGAGAACAGGTAGGAACTGAAAAAGTTTTACTGGGACTATCCGGAGGCGTTGACTCTTCT
GTTGTAGCCGCATTACTTCATAGAGCCATTGGAGAGCAACTGGTTTGTGTTTTCGTTGATACGGGTTTACTCAGACTTAA
TGAGGCGGAGCAAGTGCTGAGCATGTTCGGTCGGCATATGGGAATACGCATTATTGCAGTCAATGCCGAAGATAAATTTT
TAACTGCTTTGAAGGGAGTAACTTGCCCAGAGGAAAAGAGAAAAATTATTGGGCGTACATTTATCGAAGTCTTTGATGAG
GAAGCACAGAAGCTGACTGATATAAAGTGGCTGGCTCAGGGCACAATCTACCCCGATGTCATCGAGTCTGCAGCAACAAG
TACTAATGATGCGGCTGTGGTCATAAAGTCTCATCATAATGTCGGCGGCTTACCAGATACATTAAATCTTAAACTGCTGG
AACCTATTCGTGAGCTCTTTAAAGATGAAGTACGTCAAGTAGGTCTGGAATTGGGACTCCCGCATGATATGGTCTATCGG
CATCCCTTTCCTGGACCTGGATTGGGTGTAAGAATTTTAGCGGAAGTAAAAAAAGAATATGCGGACATATTACGTAAAGC
CGATGCTATTTTTATTGAAGAACTGCATAACGCACAGCTTTATCATAAAATCAGCCAGGCATTTGCTGTTTTTTTACCAG
TAAAGAGCGTGGGTGTGATGGGGGATGGACGCCGATACGATTACGTAATTTGTTTAAGAGCTGTTGAGACAGTTGATTTT
ATGACAGCACATTGGTCTCAATTGCCCTGGGATTTTTTAGGAAAAGTATCCAATCGAATTATTAATGAAGTAGAGGGAGT
ATCACGTGTCACTTACGATATTTCTGGCAAGCCACCTGCTACCATTGAATGGGAATGA

Protein sequence :
MNDLKKSPLLILDFGSQYTQLIARRVREMGVYCEIYPYHINHEQFKKLNPCGVILSGGPSTVTHDANPRAPQWLFESDLP
LLGICYGMQTMAVQLGGQVHSSALREFGYAELRLHGHSQLLSNIEDRTAVDGSALLDVWMSHGDKVTELPPGFKVICETR
NAPIAGMADESRQMYGLQFHPEVTHTLQGLRILQRFVVDICKAPTEWTPEHIIDEAINKIREQVGTEKVLLGLSGGVDSS
VVAALLHRAIGEQLVCVFVDTGLLRLNEAEQVLSMFGRHMGIRIIAVNAEDKFLTALKGVTCPEEKRKIIGRTFIEVFDE
EAQKLTDIKWLAQGTIYPDVIESAATSTNDAAVVIKSHHNVGGLPDTLNLKLLEPIRELFKDEVRQVGLELGLPHDMVYR
HPFPGPGLGVRILAEVKKEYADILRKADAIFIEELHNAQLYHKISQAFAVFLPVKSVGVMGDGRRYDYVICLRAVETVDF
MTAHWSQLPWDFLGKVSNRIINEVEGVSRVTYDISGKPPATIEWE

• Homologs from PAI DB

GeneGenBank Accn Product Virulance or Resistance PAI or REI Alignment Type E-val Identity
SAPIG0468 YP_005733278.1 GMP synthase [glutamine-hydrolyzing] (Glutamineamidotransferase) (GMP synthetase) Not tested SAPI-S0385 Protein 2e-124 49
SAMSHR1132_03620 YP_005324884.1 GMP synthase Not tested vSa¥á Protein 2e-124 49
guaA YP_001331415.1 GMP synthase Not tested vSa¥á Protein 2e-124 49
guaA NP_938969.1 GMP synthase Not tested Not named Protein 9e-112 48